Laboraroty Animal Research

Korean Association for Laboratory Animal Science (한국실험동물학회)
권호 표지

Study on c-fos Expression in the Lumbar Spinal Cord ofSciatic Nerve Injured Rats by Ultrasound Application

초음파 조사에 의한 좌골신경 손상된 랫드 요척수부에서의 c-fos 발현양상

Kim, Yeong-Cheol;Kim, Dong-Dae;Kim, Jin-Sang
김영철;김동대;김진상

  • Published : 20040000
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Abstract

To evaluate the effects of low-intensity ultrasound application to sciatic nerve injured rats on c-fos expression in the lumbar spinal cord, various continuous-wave ultrasound treatments with intensities of 0.2W/$cm^2$, 0.5W/c$cm^2$ and 1.0W/$cm^2$ operated at 1MHz or sham treatment were applied to the opposite inside of the nerve injury site for 1 minute every other day with a transducer moving speed of 2 cm/sec. c-Fos expression was markedly increased at 1hour after sciatic nerve injury, then gradually decreased thereafter. c-Fos expressions were significantly decreased (p < 0.05) in all the experimental groups in comparison with the control group until 3days post-injury, and the degrees of decrease were higher in 0.5W/$cm^2$ and 1W/cm2 intensity ultrasound application groups. However, no significant difference in c-fos expressions was observed between the experimental groups and the control group after 7 days post-injury. Therefore, it is suggested that low-intensity ultrasound application after peripheral nerve injury suppresses a pain transmission.

Keywords

References

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