Food Allergy; Diagnosis and Treatment

식품 알레르기의 진단과 치료

Nam, Seung-Yeon
남승연

  • Published : 20040000

Abstract

Up to $5{\%}$ of young children suffer from food allergy. Children with food allergy may present with a variety of symptoms that parents have attributed to constituents of the diet. The diagnosis and management of adverse food reactions is a challenge for physicians. Diagnostic approaches are composed of a detailed history, in vitro tests and in vivo tests. Improved diagnostic methods include more precise in vitro and in vivo tests for immunoglobulin E-mediated food allergies, in vitro assays for predicting development of oral tolerance, and novel non-invasive tests for cell-mediated food allergies such as patch testing, cytokine assays, and detection of eosinophil activation markers. The conventional diet therapy, pharmacotherapy and new immunomodulatory approaches to food allergy are also discussed. Rapidly evolving findings might provide hope for a cure of food allergy in the near future

Keywords

References

  1. Sampson HA. Adverse reactions to foods. In: Adkinson NF, Bochner BS, Yunginger JW, Holgate ST, Busse WW, Simons FER, editors. Middleton's allergy : principle and practice, St. Louise, Mosby, 2003:1619-43
  2. The Korean Academy of Pediatric Allergy and Respiratory disease Committee on Epidemiology. The epideiologic survey of allergic disease in Korean children-adolescent.: Atopic dermatitis and food allergy. Peditr Allergy Respir Dis 2002;12(suppl. 1):S57-60
  3. Bock SA, Sampson HA. Evaluation of food allergy. In: Leung DYM, Sampson HA, Geha RS, Szefler SJ, editors. Pediatric Allergy: principle and practice, St. Louise, Mosby,2003:478-87
  4. Nowak-Wegrzyn A. Future approaches to food allergy. Pediatrics 2003;111:1672-80
  5. Mofidi S, Sampson HA. Management of food allergy. In: Leung DYM, Sampson HA, Geha RS, Szefler SJ, editors. Pediatric Allergy: principle and practice, St. Louise, Mosby,2003;546-59
  6. Isolaurie E, Tahvanainen A, Peltola T, Arvola T. Breast-feeding of allergic infants. J Pediatr 1999;134:27-32 https://doi.org/10.1016/S0022-3476(99)70368-9
  7. Mofidi S. Nutritional management of pediatric food hypersensitivity. Pediatrics 2003;111:1645-53
  8. Eigenmann PA. Future therapeutic options in food allergy. Allergy 2003;58:1217-23 https://doi.org/10.1046/j.1398-9995.2003.00303.x
  9. Leung DY, Sampson HA, Yunginger JW, Burks AW Jr, Schneider LC, Wortel CH, et al. Effect of anti-IgE therapy in patients with peanut allergy. N Engl J Med 2003;348:986-93 https://doi.org/10.1056/NEJMoa022613
  10. Li XM, Serebrisky D, Lee SY, Huang CK, Bardina L, Schofield BH, et al. A murinemodel of peanut anaphylaxis: T- and B-cell responses to a major peanut allergen mimic human responses. J Allergy Clin Immunol. 2000;106:150-8 https://doi.org/10.1067/mai.2000.107395
  11. Kline JN, Waldschmidt TJ, Businga TR, Lemish JE, Weinstock JV, Thorne PS, et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol. 1998;160:2555-9
  12. Sampson HA. Immunologic approaches to the treatment of food allergy. Pediatr allergy Immunol. 2001;12(suppl 14):91-6 https://doi.org/10.1034/j.1399-3038.2001.121420.x
  13. Li X, Huang CK, Schofield BH, Burks AW, Bannon GA, Kim KH, et al. Strain-dependent induction of allergic sensitization caused by peanut allergen DNA immunization in mice. J Immunol 1999;162:3045-52
  14. Lee SY, Huang CK, Zhang TF, Schofield BH, Burks AW, Bannon GA, et al. Oral administration of IL-12 suppresses anaphylactic reactions in a murine model of peanut hypersensitivity. Clin Immunol. 2001;101:220-8 https://doi.org/10.1006/clim.2001.5122
  15. Isolauri E, Salminen S, Mattila-Sandholm T. New functional foods in the treatment of food allergy. Annals of Medicine 1999;31:299-302 https://doi.org/10.3109/07853899908995894
  16. Kalliomaki M, Salminen S, Arvilommi H. Probiotics in primary prevention of atopicdisease: a randomized palcebo-controlled trial. Lancet 2001;357:1076-9 https://doi.org/10.1016/S0140-6736(00)04259-8