he Correlation of Usual Dietary Isoflavone Intake and Serum Osteocalcin

여대생의 대두제품을 이용한 이소플라본섭취 및 혈중 Osteocalcin과의 상관성

  • 안홍석 (성신여자대학교 생활과학대학 식품영양학과) ;
  • 박윤신 (국립보건원 생명의학부 심혈관질환과)
  • Published : 2004.02.01

Abstract

Few studies have conducted the bone health benefits of usual dietary isoflavone intake in Korean college-student women. To elucidate this benefitial effects and correlations between dietary isoflavone and nutrients intake and bone formation marker (ALPase, osteocalcin), questionnaires, anthropometric measurements, serum mineral (Ca, P, Mg) concentrations were analyzed. Fifty three subjects were used in this study. The average age, height, body weight, BMI, body fat content and triceps skinfold thickness were 21.43 year, 161.07 cm, 52.81 kg, 20.48 kg/$m^2$, 20.72% and 17.59 mm respectively. Soy food intake frequencies were soybean > soybean curd > soypaste stew > soybean milk. The average calorie, protein and Ca intake were 1766.21 $\pm62.54 kcal\;66.45\pm2.00 g\;and\; 549.62 \pm 27.55 mg$ respectively. Serum ALPase activity and osteocalcin concentration were 115.74$\pm3.6u/L$ and 7.15 ng/$m\\ell$ respectively. Usual dietary isoflavone intake was positively related to calory, protein, Ca, P intake and serum Ca, Mg concentration. Serum osteocalcin concentration was negatively correlated with isoflavone intake ($r^2$=0.28, p < 0.05). In these results, usual dietary isoflavone can support an additive effect to bone health and Ca nutrition.

Keywords

References

  1. Adlercreutz H, Honjo H, Higashi A, Fotsis T, Hamalainen E, Hasegawa T, Okada H(1991): Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. Am J Clin Nutr 54(6): 1093-100
  2. Alkel DL, Germain A, Peterson CT, Hanson HB, Stewart JW, Toda T (2000): Isoflavone-rich soy protein attenuates bone loss in the lumbar spine of perimenopausal wpmen. Am J Clin Nutr 72: 844-852
  3. Ander SYT, Pijpe A, Lebrun CE, Bots ML, Peeters PH, van Staveren WA, Lamberts SW, Grobbee DE (2002): Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women. Arterioscler Thromb Vasc Biol Aug 22(8): 1316-1322
  4. Angus RM, Sambrook PN, Pockock NA, Eisman JA (1998): Dietary intake and bone mineral density. Bone Mineral 4: 265-277
  5. Bae EA, Kwon TW, Moon KS (1997): Isoflavone contents and antioxidantive effects of soybeans, soybean curd and their By-products. J Korean Soc Food Sci Nutr 26(3): 371-375
  6. Baek SK, Sung CJ(2003): A study of soy isoflavone supplementation effect on bone mineral density and mone metabolism markers in female college students with low bone mass. Korean J Nutr 36(2): 154-166
  7. Bakhit RM, Klein BP, Essex-Sorlie D, Ham JO, Erdman JJW, Porter SM (1994): Intake of 25g of soybean protein with or without soybean fiber alters plasma lipids in men with elevated cholesterol concentrations. J Nutr 124(2): 213-222 https://doi.org/10.1093/jn/124.2.213
  8. Bell RR, Draper HH, Tzeng DYM, Shin HK (1977): Physiological responces of human adults to foods containing phosphate additives. J Nutr 107: 42-50 https://doi.org/10.1093/jn/107.1.42
  9. Beyen AC, West CE, Spaaij CJ, Huisman J, Van Lwwuwen P, Schutte JB, Hacheng WH (1990): Cholesterol metaboism, digestion rates and postprandial changes in serum of swine fed purified diets containing either casein or soybean protein. J Nutr 120(5): 422-430 https://doi.org/10.1093/jn/120.5.422
  10. Cassidy A, Binghanm S (1995): Biological effects of isoflavones in young women: importance of the chemical composition of soybean products. British J Nutr 74: 587-601 https://doi.org/10.1079/BJN19950160
  11. Choi M (2002): Effects of soy protein on bone mineral content and bone mineral density in growing male rats. Korean J Nutrition 35(4): 409-413
  12. Cooper C, Campion G, Melton LJ, 3rd (1989): Hip fractures in the elderly: a world-wide projection. Osteoporos Int 2: 285-289 https://doi.org/10.1007/BF01623184
  13. Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley J, Black D, Vogt TM (1995): Risk factors for hip fracture in white women: study of osteoporotic fractures in reaseacg group. N Engl J Med 332: 762-773
  14. Goodman-Gruen D, Kritz-Silverstein D (2001): Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 131(4): 1202-1206
  15. Googman-Gruen D and Kritz-Silverstein D (2001): Usual dietary isoflavone intake is associated with cardiovascular disease risk factors in postmenopausal women. J Nutr 131: 1202-1206
  16. Hankin JH, Yu MC, Maskarinec G, Low SH, Custer LJ (1999): Isoflavones levels in soy foods consumed by multiethnic populations in Singapore and Hawaii. J Agric Food Chem 47: 977-986 https://doi.org/10.1021/jf9808832
  17. Hauschka PV, Lian JB, Cole DE, Gundberg CM (1989): Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev 69(3): 990-1047 https://doi.org/10.1152/physrev.1989.69.3.990
  18. Hauschka PV, Wians FH Jr(1989): Osteocalcin-hydroxyapatite interaction in the extracellular organic matrix of bone. Anat Rec 224(2): 180-188
  19. Ho SC (1999): Soy consumption and potential benefits for bone and heart health in the Chinese population. 8th Asian Congress of Nutrition. Aug 29-Sep.2 Seoul, Korea
  20. Hong JY, Choue R (1999): The effects of Vitamin K supplements on serum osteocalcin carboxylation in postmenopausal women. Korean J Nutrition 32(6): 726-731
  21. Jeong JH, Kim JS, Lee SD, Choi SH, Oh MJ (1998): Studies on the contents of free amino acids, organic acids and isoflavones in commercial soybean paste. J Korean Soc Food Sci Nutr 27(1): 10-15
  22. Kalu DN, Masoro EJ, Yu BP, Hardin RR, Hollis BW (1988): Modulation of age-related hyperparathyroidism and senile bone loss in Fischer rats by soy protein and food restriction. Endocrinology 122(5): 1847-1854 https://doi.org/10.1210/endo-122-5-1847
  23. Kim SH, Choi BY (2001): Ca and P balance in Korean female adolescents. Korean J Nutrition 34(4): 433-439
  24. Kleibeuke JH, WWelberg JW, Mulder NH, van der Meer R, Cats A, Limberg AJ, Lloyd T, Andon MB, Rollings N, Martel JK, Landis R, Demers LM, Eggli DF, Lieselhorst K, Kalin HE (1993): Calcium supplementation and and bone mineral density in adolescent girls. J Am Med Assoc 270: 841-844 https://doi.org/10.1001/jama.270.7.841
  25. Kleijn MJ, van der Schouw YT, Wilson PW, Adlercreutz H, Mazur W, Grobbee DE, Jacques PF (2001): Intake of dietary phytoestrogens is low in postmenopausal women in the United States: the Framingham study (1-4). J Nutr 131(6): 1826-1832
  26. Kleijn MJ, van der Schouw YT, Wilson PW, Grobbee DE, Jacques PF (2002): Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S.women: the Framingham study. J Nutr 132(2): 276-282
  27. Laurin D, Jacques H, Moorjani S, Steinke FH, Gange C, Brun D, Lupien PJ (1991): Effects of a soy-protein beverage on plasma lipoprotein in children with familial hypercholesterolemia. Am J Clin Nutr 54(1): 98-103 https://doi.org/10.1093/ajcn/54.1.98
  28. Lee MH, Park YH, Oh HS, Kwak TS (2002): Isoflavone content in soybean and its processed products. Korean J Food Sci Technol 34(3): 365-369
  29. Lee SK, Lee MJ, Yoon S, Kwon DJ (2000): Estimated isoflavone intake from soy products in Korean middle-aged women. J Korean Soc Food Sci Nutr 29(5): 948-956
  30. Lee SK, Lee MJ, Yoon S, Kwon DJ (2000): Estimated isoflavone intake from soy products in Korean middle-aged women. J Korean Soc Food Sci Nutr 29(5): 948-956
  31. Maskrience G, Singh S, Meng L, Franke AA (1998): Dietary soy intake and urinary isoflavone excretion among women from a multiethnic population. Cancer Epidemiology, Biomarkers & Prevention 7: 613-619
  32. Meinertz H, Nilausen K, Faergeman O (1989): Soy protein and casein in cholesterol-enriched diets:effects on plasma lipoproteins in normolipidemic subjects. Am J Clin Nutr 50(4): 786-793 https://doi.org/10.1093/ajcn/50.4.786
  33. Michaelsson K, Holmberg L, Mallmin H, Wolk A, Bergstrom R, Ljunghall S (1995): Diet, bone mass, and osteocalcin: a cross-sectional study. Calcif Tissue Int 57(2): 86-93 https://doi.org/10.1007/BF00298425
  34. Ministry of Health and welfare National report of Health &Nutrition survey (1999)
  35. Miriam JJ, van der Schouw YT, Wilson PWF, Grobbee DE and Jacques PF (2002): Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in postmenopausal U.S. Women. J Nutr 132: 276-282
  36. Na HB, Kim HJ, Park J (2002): Effects of calcium supplementation and exercise on bone mineral density in middle-aged women. Korean J Nutrition 35(9): 962-969
  37. Picherit C, CoXan V, Bennetau-Pelissero C, Kati CS, Davicco M, Lebecque P, Barlet J(2000): Daidzein is more eficient than genistein in preventing ovariectimy-induced bone loss in rats. J Nutr 130: 1675-1681
  38. Potter SM, Baum JA, Teng HT, Stilman RJ,Shay NF, Erdman JW (1998): Soy protein and isoflavone: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68 (6 suppl): 1375-1379 https://doi.org/10.1093/ajcn/68.6.1375S
  39. Shon MY, Seo KI, Park SK, Cho YS, Sung NJ(2001): Some biological activities and isoflavone content of chungkugjang prepared with black bean and Bacillus strains. J Korean Soc Food Sci Nutr 30(4): 662-667
  40. Song YJ, Paik HY (2003): The effect of dietary, biochemical and other factors on bone mineral density changes for 2 years in Korean college women. Korean J Nutrition 36(2): 175-182
  41. Stechell KDR (1998): Phytoestrogens: the biochemistry, physiology, and implications for human health soy isoflavones. Am J Clin Nutr 68 (Suppl): 1333S-1346S https://doi.org/10.1093/ajcn/68.6.1333S
  42. Sung CJ, Choi MK, Jo JH, Lee JY (1993): Relationship among dietary intake, blood level and urinary excretion of minerals and blood pressure in Korean rural adult men and women. Kor J Nutr 26: 89-97
  43. Sung CJ, Choi SH, Kim MH, Park MH, Ko BS, Kim HK (2000): Astudy on dietary intake from soy foods and urinary isoflavone excretion and menopausal symtoms in Korean women in rural areas. Korean J Community Nutrition 5(1): 120-129
  44. Takahashi M, Oikawa M, Nagano A (2000): Effect of age and menopause on serum concentrations of pentosidine, an advanced glycation end product. J Gerontol A Biol Sci Med Sci 55(3): M137-140
  45. Tasker TE, Potter SM (1993): Effects of dietary protein source on plasma lipids, HMG-CoA reductase activity, and hepatic glutathione levels in gerbils. J Nutr Biochem 4: 458-462 https://doi.org/10.1016/0955-2863(93)90063-3
  46. Tietz NW, Rinker AD, Shaw LM (1983): IFCC methods for the measurement of catalytic concentration of enzymes Part 5. IFCC method for alkaline phosphatase (orthophosphoric-monoester phosphohydrolase, alkline potimum., EC 3.1.3.1). J Clin Chem Clin Biochem 21: 731-748
  47. van der Schouw YT, Pijpe A, Lebrun CE, Bots ML, Peeters PH, van Staveren WA, Lamberts SW, Grobbee DE (2002): Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women. Arterioscler Thromb Vasc Biol 22(8): 1316-1322
  48. Wangen KE, Duncan AM, Merz-Demlow BE, Xu X, Marcus R, Phipps WR, Kurzer MS (2000): Effects of soy isoflavones on markers of bone turnover in premenopausal and postmenopausal women. J Clin Endocrinol Metab 85(9): 3043-3048
  49. Whyte MP, Mahuren JD, Fedde KN, Cole FS, McCabe ERB, Cobum SP (1988): Perinatal hypophosphatasis tissue levels of vitamin B-6 are unremarkable despite markedly increased circulation concentrations of pyridoxal-5' phosphate. J Clin Invest 81: 1234-1239 https://doi.org/10.1172/JCI113440
  50. Wong WW, Smith EO, Stuff JE, Hachey DL, Heird WC, Pownell HJ (1998): Cholesterol-lowering effect of soy protein in normo-cholesterolemic and hypercholesterolemic men. Am J Clin Nutr 68(6 suppl): 1385-1389 https://doi.org/10.1093/ajcn/68.6.1385S
  51. Yasumizu T, Okuno T, Fukada Y, Hoshi K (2000): Age-related changes in bone mineral density and serum bone-related proteins in premenopausal and postmenopausal Japanese women. Endocr J 47(2): 103-109
  52. Yang Ae Kim, Chung Ja Seung (1987): The Effect of Dietary Sodium on Calcium Metabolism in Healthy Young Adult Women. Korean J Nutrition 20(4): 246-257
  53. You CH, Kim HS, Lee JS, Kim JY (2001): A study on Ca and P balnce in Korean women. Korean J Nutrition 34(1): 54-61
  54. Yu KH, Kong YA, Yoon JS (1996): Astudy on dietary factors, urinary levels of Ca, Na and the bone status of women in urban and rural areas. Korean J Community Nutrition 1(1): 71-78