Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Antioxidant Activities of Isoflavones from the Rhizomes of Belamcanda chinensis on Carbon Tetrachloride-Induced Hepatic Injury in Rats

  • Jung, Sang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National University, Natural Products Research Center, Korea Institute of Science and Technology) ;
  • Lee, Yeon-Sil (Seokwon Life Science Research Institute) ;
  • Lim, Soon-Sung (Silver Biotechnology Research Center, Hallym University) ;
  • Lee, Sanghyun (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • Shin, Kuk-Hyun (Natural Products Research Institute, College of Pharmacy, Seoul National University, Seokwon Life Science Research Institute) ;
  • Kim, Yeong-Shik (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Published : 2004.02.01
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Abstract

The present study was carried out to clarify whether tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis (Iridaceae) inhibit hepatic damage induced by carbon tetrachloride ($CCl_4$)-intoxication in rats by the experimental methods in vitro and in vivo. Tectorigenin and tectoridin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats, as well as in a lipid peroxidation causing a significant decrease in malondialdehyde (MDA) production by thiobarbituric acid (TBA)-reactant assay. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in $CCl_4$-intoxicated rats. These results suggested that tectorigenin and tectoridin isolated from the rhizomes of B. chinensis possess not only the antioxidative, but also the hepatoprotective activities in $CCl_4$ -intoxicated rats.

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References

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