Biotechnology and Bioprocess Engineering:BBE

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
권호 표지

Microfluidic Components and Bio-reactors for Miniaturized Bio-chip Applications

  • Euisik Yoon (Department of Electrical Engineering and Computer Science, Korea Advanced Institute of Science and Technology) ;
  • Yun, Kwang-Seok (Department of Electrical Engineering and Computer Science, Korea Advanced Institute of Science and Technology)
  • Published : 2004.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

In this paper miniaturized disposable micro/nanofluidic components applicable to bio chip, chemical analyzer and biomedical monitoring system, such as blood analysis, micro dosing system and cell experiment, etc are reported. This system includes various microfluidic components including a micropump, micromixer, DNA purification chip and single-cell assay chip. For low voltage and low power operation, a surface tension-driven micropump is presented, as well as a micromixer, which was implemented using MEMS technology, for efficient liquid mixing is also introduced. As bio-reactors, DNA purification and single-cell assay devices, for the extraction of pure DNA from liquid mixture or blood and for cellular engineering or high-throughput screening, respectively, are presented.

Keywords

References

  1. Proceedings of 11th IEEE MEMS '98 A self-priming and bubble-tolerant piezoelectric silicon micropump for liquid and gases Linnemann,R.;P.Woias;C.D.Senfft;J.A.Ditterich
  2. Proceedings of 11th IEEE MEMS '95 A bidirectional silicon micropump Zengerle,R.;S.Kluge;M.Richter;A.Richter
  3. Sens. Actuators v.A21;A22;A23 A thermo-pneumatic micropump based on micro-engineering techniques Van De Pol,F.C.M.;H.T.G.Van Lintel;M.Elwenspoek;J.H.JFluitman
  4. Proceedings of IEEE Solid-State Sensor and Actuator Workshop A bidirectional magnetic micropump on a silicon wafer Zhang,W.;C.H.Ahn
  5. DSC-Vol. 59, Microelectromechanical Systems (MEMS) A bimetallic thermally actuated micropump Yang,Y.;Z.Zhou;X.Ye;X.Jiang
  6. J. Microelectromech. Syst. v.7 Thin-film shape-memory alloy actuated micropumps Benard,W.L.;H.Kahn;A.H.Heuer;M.A.Huff https://doi.org/10.1109/84.679390
  7. J. Microelectromech. Syst. v.11 A surface-tension driven micropump for low-voltage and low-power operations Yun,K.S.;I.J.Cho;J.U.Bu;C.J.Kim;E.Yoon https://doi.org/10.1109/JMEMS.2002.803286
  8. Digest of Technical Papers of Transducers '97 Microfluidic systems for clinical diagnostics Chiem,N.;C.Colyer;J.D.Harrison
  9. Proceedings of IEEE Solid-State Sensor and Actuator Workshop Low Reynolds number micro-fluidic devices Brody,J.B.;P.Yager
  10. Proceedings of the International Sensor Conference A passive micro mixer in a two-way separated three-dimensional microchannel formed by using polydimethylsi-loxane (PDMS) Kim,B.G.;J.H.Kim;J.B.Yoon;E.Yoon
  11. J. Microelectromech. Syst. v.9 Passive mixing in a three-dimensional serpentine micro-channel Liu,R.H.;M.A.Stremler;K.V.Sharp;M.G.Olsen;J.G.Santiago;R.J.Adrian;H.Aref;D.J.Beebe https://doi.org/10.1109/84.846699
  12. Electrophoresis v.17 Modern genome research and DNA diagnostics in domestic animals in the light of classical breeding techniques Buitkamp,J.;J.T.Epplen https://doi.org/10.1002/elps.1150170102
  13. Proc. IEEE v.86 Microfabricated devices for genetic diagnostics Mastrangelo,C.H.;M.A.Burns;D.T.Burke https://doi.org/10.1109/5.704282
  14. Proceedings of the Micro TAS Symposium A disposable passive microfluidic system integrated with micromixer and DNA purification chip for DNA sample preparation Kim,J.H.;B.G.Kim;M.La;J.B.Yoon;E.Yoon
  15. J. Colloid Interface Sci. v.181 Driving forces for DNA adsorption to silica om perchlorate solutions Melzak,K.A.;C.S.Sherwood;R.F.B.Turner;C.A.Haynes https://doi.org/10.1006/jcis.1996.0421
  16. IEEE Eng. Med. Biol. v.18 Fast and precise positioning of single cells on planar electrode substrates Thielecke,H.;T.Stieglitz;H.Beutel;T.Matthies;H.H.Ruf;J.U.Meyer https://doi.org/10.1109/51.805144
  17. Proceedings of the Micro TAS Symposium Design and fabrication of micro/nano-fluidic chip performing single-cell positioning and nanoliter drug injection for single-cell analysis Yun,K.S.;S.I.Lee;G.M.Lee;E.Yoon