Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

Effects of Red-Yeast-Rice Supplementation on Bone Mineral Density and Bone Mineral Content in Overiectomized Rats

홍국의 첨가가 난소절제 쥐에서 골밀도 및 골함량에 미치는 영향

  • Published : 2004.07.01
Download PDF
⟨ Previous Next ⟩

Abstract

This study was performed to evaluate the effect of red-yeast-rice on bone metabolism in overiectomized (OVX) rats. Forty female Sprague-Dawley rats (body weight 210 $\pm$ 5 g, 9 weeks old age) were divided into two groups. One group were OVX, and the other group received sham operation (SHAM), and received either control diet (20％ casein) or a red-yeast-rice power supplemented diet (0.1％) for 9 weeks. And then each rat group was further divided into control diet (casein 20％) and red-yeast-rice powder supplemented (0.1％) diet group. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks. Bone mineral density (BMD) and bone mineral content (BMC) were measured using PIXImus (GE Lunar Co, Wisconsin, USA) in spine and femur on 5, 9 weeks after feeding. The serum and urine concentrations of Ca and P were determined. Bone formation was measured by serum osteocalcin and alkaline phosphatase (ALP) concentrations. And bone resorption rate was measured by deoxypyridinoline (DPD) crosslinks immunoassay and corrected for creatinine. Serum osteocalcin, growth hormone, IGF-l and calcitonin were analyzed using radioimmunoassay kits. Urinary Ca and P excretion were not significantly different among the groups. Within the OVX group, the red-yeast-rice group had a lower crosslinks value than the casein group. Therefore the red-yeast-rice supplemented groups had a lower bone resorption ratio than the casein group in the ovariectomized rats. And, the red-yeast-rice group had significantly higher IGF-l hormone than casein group in ovariectomized rats. The red-yeast-rice group had higher spine bone mineral content than those of control group within the OVX groups. This study was an important first step in establishing that the observed beneficial effects of red-yeast-rice on bone, and this study also established the need for a study on the long-term effect of this supplement in a human.

Keywords

References

  1. Population Projections for Korean. 2000-2050 Korean National Statistical Office
  2. Korean J Nutr v.33 no.3 A study on the factors affecting bone mineral density in adult women-based on the mothers of elementary school students Kim KR;Kim KH;Lee EK;Lee SS
  3. Korean J Nutr v.32 no.2 A study on the bone mineral density and related factors in Korean postmenopausal women Lee HJ;Lee HO
  4. 2001 National Health and Nutrition Survey Report Korean Health Industry Development Institute/Ministry of Health and Welfare
  5. Am J Clin Nutr v.73 no.1 A high raio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women Sellmeyer DE;Stone KL;Sebastian A.;Cummings SR https://doi.org/10.1093/ajcn/73.1.118
  6. Am J Clin Nutr v.70 Plant-based diets and bone heath:nutritional implications Anderson JJB https://doi.org/10.1093/ajcn/70.3.539s
  7. Osteoporosis Int v.2 Hip fractures in the elderly:a world-wide projection Cooper C;Campion G ;Melton LJ https://doi.org/10.1007/BF01623184
  8. J Am Coll Cardiol v.35 Phytorstrogens and cardiovascular health Lissin LW;Cooke JP https://doi.org/10.1016/S0735-1097(00)00590-8
  9. Fang Me's illustrated cookbook of regional Chinese cuisine Red yeast flavonoid duck Mei F.
  10. N Engl J Med v.333 Prevention of coronary heart disease with pravastinin mem with hypercholesterolemia Shepherd J;Cobbe SM;Ford I https://doi.org/10.1056/NEJM199511163332001
  11. J Antibiotic v.33 Monacolin, a new hypercholesterolemic agent that specifically inhibits 3-hydroxy-3methyl glutaryl coenzyme A reductase Endo A https://doi.org/10.7164/antibiotics.33.334
  12. Am J Clin Nutr v.69 no.2 Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement Heber D;Yip L;Ashley JM;Elashoff DA;Elashoff RM;Go VLW https://doi.org/10.1093/ajcn/69.2.231
  13. J Korean Soc food Sci Nutr v.32 no.2 Hepatic oxygen free radical metabolizing enzyme activities and serum lipid profile in rats fed diet supplemented with Monascus Pigment Yu TS;Kim HH;Yoon CG https://doi.org/10.3746/jkfn.2003.32.2.244
  14. JAMA v.283 HMG-CoA reductase inhibitors and the risk of fractures Meier CR;Schlienger RG;Kraenzlin ME;Schlegel B;Jick H https://doi.org/10.1001/jama.283.24.3205
  15. JAMA v.283 HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients Wang PS;Solomon DH;Mogun H;Avom J https://doi.org/10.1001/jama.283.24.3211
  16. Lancet v.355 Inhibitors of hydroxymethyl-glutarylcoenzyme A reductase and the risk of fractures among older women Chan KS;Andrade SE;Boles M https://doi.org/10.1016/S0140-6736(00)02400-4
  17. Lancet v.355 Pra statins and increased bone mineral density in postmenopausal women Edwards CH;Hart DJ;Spector TD https://doi.org/10.1016/S0140-6736(00)02408-9
  18. Science v.286 Stimulation of bone formation in vitro and in rodents by statins Mundy G;Garrentt R;Harris S https://doi.org/10.1126/science.286.5446.1946
  19. Am J Clin Nutr v.78 Soy protein with isoflavones has favorable effects on endothelial function that are independent of lipid and antioxidant effects in healthy postmenopausal women Steinberg FM;Guthrie NL;Villablanca AC;Kumar K;Murray MJ https://doi.org/10.1093/ajcn/78.1.123
  20. Am J Clin Nutr v.68 no.SUP. Role of soy protein with normal of reduced isoflavone content in reversing bone loss induced by ovarian hormone deficiency in rats Arjmandi AH;Getlinger MJ;Goyal NV;Alekel L;Hasler CL;Juma S;Drum ML;Hollis BW;Kukreja SC https://doi.org/10.1093/ajcn/68.6.1358S
  21. J Kor Soc Food Sci Nutr v.32 no.3 Effect of Monascus Koji on blood pressure and serum cholesterol composition of SHR by Chronic Dietary administration Rhyu MR;Kim EY;Han JS https://doi.org/10.3746/jkfn.2003.32.3.464
  22. Korean J Nutr v.29 no.6 The effect of dietary calcium level on bone mineral density and bone mineral content in ovariectomized female rats Kim KH;Choi MJ;Lee IK
  23. Korean J Nutr v.37 no.2 The effect of dietary protein source and sulfur amino acid content on bone metabolism in growing rats Choi MJ;Jung SH
  24. des Internaional Symposium on Osteoporosis Viborg Denmark High protein meals, insular hormones and urinary calcium excretion in human subjects Anderson JJB;Thomsen K;Crhistiansen C;Johansen JS
  25. J Nutr v.126 Dietary soybean protein prevents bone loss in an ovariectomized rat model of osteoporosis Arjmandi BA;Alekel L;Hollis BW;Amin D;Stacewicz-Sapuntzakis M;Guo P;Jukreja SC
  26. Phsiol Rev v.69 Osteocalcin and matrix gla protein:Vitamin K-dependent proteins in bone Hauschka PV;Lian JB;Dole DEC;Gundberg CM https://doi.org/10.1152/physrev.1989.69.3.990
  27. Environ Health Perspect v.102 Dietary estrogens act through estrogen receptor mediated processes and show no anti-estrogenicity in cultured breast cancer cells Makela S;Davis VL;Tally WC
  28. J Bone Min Res v.9 no.1 Influence of age on cyclosporin A-induced alterations in bone mineral metabolism in the rat in vivo Katz I;Li M;Joffe I;Stein B;Jacobs T;Liang XG;Ke HZ;Jee W;Epistein S https://doi.org/10.1002/jbmr.5650090109
  29. Korean J Nutr v.36 no.6 Effects of soy and isoflavones on bone marks and hormones in growing female rats Choi MJ;Cho HJ
  30. Korean J Nutr v.29 Effect of Sodium chloride supplementation on bone metabolism in rats consuming a low calcium diet Choi MJ;Cho HJ
  31. Primer on the metabolic bone diseases and disorder of mineral metabolism(3rd ed.) Biochemical Markers of Bone Turnover Eyre DR;Favus MJ(ed.)
  32. J Nurt v.130 no.7 Daidzein is more efficient than genistein in preventing ovariectomy-induced bone loss in rats Picherit C;Coxam V;Bennetau-Pelissero C;Kati-Coulibaly S;Davicco MJ;Lebecque P;Barlrt JP
  33. Calcif Tissue Int v.49 no.SUP. Pathogenesis of osteoporosis Vaanannen HK https://doi.org/10.1007/BF02555080
  34. Eur J Clin Nutr v.48 The cell biology of bone growth Price JS;Oyajobi BO;Russell RGG
  35. J Nutr v.132 no.9 Soy protein supplementation increases serum insulin-llike growth factor-I in young and old men but does not affect markers of bone metabolism Khalil DA;Lucas EA;Juma S;Smith BJ;Payton ME;Arjmandi BH
  36. J Bone Mineral Res v.7 Weight-training effects on bone mineral density in early postmenopausal women Pruitt LA;Jackson RD;Bartels RL;Lehmard HJ https://doi.org/10.1002/jbmr.5650070209
  37. Dissertation of Ph.D in University of washington Soy consumption and bone mineral density in older Japanese American Women in King country Rice M.M.
  38. Am J Epidemiology v.144 no.9 Very low rates of hip fracture in Beijing, People's Republic of China the Beijing osteoporosis project Xu L;Lu A;Zhad X;Chen X;Cummings SR https://doi.org/10.1093/oxfordjournals.aje.a009024