Macromolecular Research

The Polymer Society of Korea (한국고분자학회)
권호 표지

Sulfonated Poly(ethylene glycol) Containing Methacrylate Copolymer Surfaces; Preparation, Characterization and In Vitro Biocompatibility

  • Park, Ki-Dong (Department of Molecular Science and Technology, Ajou University) ;
  • Park, Hyung-Dal (Department of Molecular Science and Technology, Ajou University) ;
  • Lee, Hee-Jung (Biomaterials Research Center, Korea Institute of Science and Technolog) ;
  • Kim, Young-Ha (Biomaterials Research Center, Korea Institute of Science and Technolog) ;
  • Tooru Ooya (School of Materials Science, Japan Advanced Institute of Science and Technolog) ;
  • Nobuhiko Yui (School of Materials Science, Japan Advanced Institute of Science and Technology)
  • Published : 2004.08.01
Download PDF
⟨ Previous Next ⟩

Abstract

Poly(ethylene glycol) (PEG1K) and sulfonated PEG (PEG1K-SO$_3$) methacrylate (MA) copolymers have been prepared and characterized. The structures of the synthesized copolymers were confirmed by $^1$H and $^{13}$ C NMR spectroscopy and elemental analysis. The bulk characteristics of the copolymers were evaluated by viscosity and thermal analysis. The surface properties of the copolymers were investigated using dynamic contact angle measurements and electron spectroscopy for chemical analysis. The hydrophilicity of the surfaces modified with PEG1KMA or PEG1K-SO$_3$MA increased, possibly as a result of the orientation of the hydrophilic PEG1KMA/PEG1K-SO$_3$MA chains into the water phase. Platelets adhered less to the surfaces of the copolymers than they did to a polyurethane control. In addition, adhesion of platelets to the copolymer surfaces decreased upon increasing the chain density of PEG1KMA and sulfonated PEG1KMA in the copolymers. Both bacterial adhesion and protein adsorption were significantly reduced on the copolymer surfaces and their levels differ depending on the kind of surface or media.

Keywords

References

  1. J. Biomater. Sci. Polym. Edn. v.9 D. K. Han;K. D. Park;G. H. Ryu;Y. H. Kim https://doi.org/10.1163/156856298X00497
  2. Advances in Polymeric Biomaterial Science Y. H. Kim;K. D. Park;D. K. Han;T. Akaike (et al.)(Ed.)
  3. Biomaterials v.11 J. H. Lee;P. Kopeckova;J. Kopecek;J. D. Andrade https://doi.org/10.1016/0142-9612(90)90058-X
  4. J. Biomed. Mater. Res. v.34 J. H. Lee;B. J. Jeong;H. B. Lee https://doi.org/10.1002/(SICI)1097-4636(199701)34:1<105::AID-JBM14>3.0.CO;2-J
  5. J. Biomed. Mater. Res. v.40 J. H. Lee;Y. M. Ju;W. K. Lee;K. D. Park;Y. H. Kim https://doi.org/10.1002/(SICI)1097-4636(199805)40:2<314::AID-JBM17>3.0.CO;2-L
  6. Prog. Polym. Sci. v.20 J. H. Lee;H. B. Lee;J. D. Andrade https://doi.org/10.1016/0079-6700(95)00011-4
  7. J. Biomater. Sci. Polym. Edn. v.4 D. K. Han;G. H. Ryu;K. D. Park;S. Y. Jeong;Y. H. Kim;B. G. Min https://doi.org/10.1163/156856293X00087
  8. J. Biomed. Mater. Res. v.27 D. K. Han;K. D. Park;S. Y. Jeong;Y. H. Kim;U. Y. Kim;B. G. Min https://doi.org/10.1002/jbm.820270812
  9. ASAIO J. v.39 D. K. Han;K. B. Lee;K. D. Park;C. S. Kim;S. Y. Jeong;Y. H. Kim;H. M. Kim;B. G. Min
  10. ASAIO J. v.40 K. D. Park;J. Y. Yun;D. K. Han;S. Y. Jeong;Y. H. Kim https://doi.org/10.1097/00002480-199407000-00026
  11. Biomaterials v.16 D. K. Han;K. D. Park;S. Y. Jeong;Y. H. Kim;N. Y. Lee;H. I. Cho;B. G. Min https://doi.org/10.1016/0142-9612(95)98819-Z
  12. ASAIO J. v.42 K D. Park;K. Suzuki;W. K. Lee;J. E. Lee;Y. H. Kim;Y. Sakurai;T. Okano https://doi.org/10.1097/00002480-199609000-00117
  13. Polymer(Korea) v.21 H. J. Lee;K. D. Park;D. K. Han;Y. H. Kim;I. Cho
  14. Biomaterials v.18 K. D. Park;W. K. Lee;J. Y. Yun;D. K. Han;Y. H. Kim;H. M. Kim;K. T. Kim https://doi.org/10.1016/S0142-9612(96)00096-8
  15. Macromol. Symp. v.118 Y. H. Kim;D. K. Han;K. D. Park;S. H. Kim https://doi.org/10.1002/masy.19971180174
  16. J. Biomater. Sci. Polym. Edn. v.9 D. K. Han;K. D. Park;J. A. Hubbell;Y. H. Kim https://doi.org/10.1163/156856298X00082
  17. Biomaterials v.19 K. D. Park;Y. S. Kim;D. K. Han;Y. H. Kim;E. H. Bae;H. Suh;K. S. Choi https://doi.org/10.1016/S0142-9612(97)00245-7
  18. J. Colloid and Surfaces B: Biointerfaces v.18 H. J. Lee;K. D. Park;H. D. Park;W. K. Lee;D. K. Han;S. H. Kim;Y. H. Kim https://doi.org/10.1016/S0927-7765(99)00161-7
  19. Biomaterials v.15 B. Wesslen;M. Kober;C. Freij-Larsson;A. Ljungh;M. Paulsson https://doi.org/10.1016/0142-9612(94)90052-3
  20. J. Biomater. Sci. Polym. Edn. v.6 B. E. Rabinow;Y. S. Ding;C. Qin;M. L. McHalsky;J. H. Schneider;K. A. Ashline;T. L. Shelbourn;R. M. Albrecht
  21. Development in Polymer Characterizations A. Dilks(ed.);J. V. Dawkins(ed.)
  22. J. Colloid Interf. Sci. v.142 S. I. Jeon;J. H. Lee;J. D. Andrade;P. G. De Gennes https://doi.org/10.1016/0021-9797(91)90043-8
  23. J. Colloid Interf. Sci. v.142 S. J. Jeon;J. D. Andrade https://doi.org/10.1016/0021-9797(91)90044-9
  24. Biomaterials v.13 N. P. Desai;S. F. A. Hossiany;J. A. Hubbell https://doi.org/10.1016/0142-9612(92)90160-P
  25. Med. Plastics Biomaterals P. Sioshanisi;E. J. Tobin
  26. Biomaterials v.13 M. J. Bridgett;M. C. Davies;S. P. Denyer https://doi.org/10.1016/0142-9612(92)90159-L
  27. ASAIO J. v.41 S. Nagaoka;H. Kawakami https://doi.org/10.1097/00002480-199507000-00032
  28. New Polymeric Mater. v.3 Z. Schierholz;B. Jansen;H. Steinhauser;G. Peters;F. Schumacher-Perdreau;G. Pulverer
  29. J. Control. Release v.40 L. L. Woodyard;T. L. Bowersock;J. J. Turek;G. P. McCabe;J. A. DeFord https://doi.org/10.1016/0168-3659(95)00135-2