Journal of Korean Academy of Nursing (대한간호학회지)

Korean Society of Nursing Science (한국간호과학회)
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The Effects of Aerobic Exercise on Hormones, Blood Lipids and Body Composition in Middle-Aged Obese Women according to $\beta$3-Adrenergic Receptor Gene Polymorphisms

비만 유전자 유.무에 따른 유산소 운동요법이 중년 비만여성의 대사조절 호르몬, 혈청지질 및 신체구성에 미치는 효과

  • Published : 2004.10.01
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Abstract

Purpose: This research was conducted to provide basic information about the effects of aerobic exercise on physiological change in middle-aged obese women according to differences of ${\beta}$3-adrenergic receptor polymorphisms. Method: Twenty-nine middle aged obese women with over 30%BMI were divided into three groups according to ${\beta}$3-adrenergic receptor gene polymorphism[Variable Group(VG):9, Normal Group(NG):10, Control Group(CG):10]. The VG and NG groups performed walking at 50% exercise intensity for 30 minutes a day, 4 days a week, for 12 weeks. The data was analyzed using the SPSS program. Result: The level of leptin, insulin and % body fat in the VG and NG groups was significantly lower than those of the CG after 12 weeks. In addition, the level of HDL-C in the VG and NG was significantly higher than that of the CG after 12 weeks. However, TC, TG and body weight between groups didn't appear significant at the end of 12 weeks. Conclusions: Aerobic exercise didn't cause differences in persons with differing ${\beta}$3-adrenergic receptor gene polymorphisms, but aerobic exercise affected the physiological change in middle-aged obese women. The findings suggest that aerobic exercise is a desirable nursing intervention for obesity control in middle-aged obese women.

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References

  1. American College of Sports Medicine (1991). Guidelines for exercise testing and prescription(4th ed). Philadelphia: Lea & Febiger
  2. Ballantyne, D., Clark, A., Dyker, G. S., Gillis, C. R., Hawthorne, V. M., Henry, D. A., Hole, D. S., Murdock, R. M., & Steward, G. M. (1982). Prescribing exercise for the healthy; assessment of compliance and effects on plasma lipids and lipoprotein. Health Ball, 32, 169
  3. Bernard, G., Leigh, R., Paule, B., William, C., Michael, F., Mark, L., and Scott, O. (1999). Plasma leptin concentration on obese children : changes during 4-mo periods with and without physical training. Am J Clin Nutr, 69, 388-394
  4. Bouchard, C., Perusse, L. (1993). Genetics of obesity. Annu Rev Nutr, 13, 337-354 https://doi.org/10.1146/annurev.nu.13.070193.002005
  5. Corella, D., Guillen, M., Portoles, O., Sorli, J. V., Alonso, V., Folch, J., Saiz, C. (2001). Gender specific association of the Trp64Arg mutation in the beta3 adrenergic receptor gene with obesity related phenotypes in a mediterranean population : interaction with a common lipoprotein lipase gene variation. J Int Med, 250(4), 348-360
  6. Efendic, S., Kindmark, H., Berggren, P. O. (1991). Mechanisms involved in the regulation if the insulin secretory process. J Int Med, 229(Suppl 2), 9-22
  7. Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997). Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature, 385, 165-168 https://doi.org/10.1038/385165a0
  8. Goodyear, L. T., Van Houten, D. R., & Frosoe, M. S. (1990). Immediate and delayed effects of marathon running on lipids and lipoprotein in woman. Med Sci Sports Exerc, 22, 588-592 https://doi.org/10.1249/00005768-199010000-00008
  9. Han, E. P. (1999). Effect of training and detraining on blood lipids and body composition in middle aged women. Unpublished master dissertation, The Korea National Sports University of Korea, Seoul
  10. Herrnardez, M. N., & Perlemuter, L. (1999). Leptin : a genetic solution to obesity? press Med., 26(16), 770-773
  11. Hsueh, W., Cole, S., Shuldiner, A., Beamer, B., Blangero, J., Hixson, J., MacCluer, J., Mitchell, B. (2001). Interactions between variants in the $\beta $_3$ adrenergic receptor and peroxisome proliferator activated receptor gene and obesity. Diabetes Care 24, 672-677 https://doi.org/10.2337/diacare.24.4.672
  12. Ishii, T., Yamakita, T., Yamagami, K., Yamamoto, T., Miyamoto, M., Kawasaki, K., Hosoi, M., Yoshioka, K., Sato, T., Tanaka, S., Fujii, S. (2001). Effect of exercise training on serum liptin levels in type 2 diabetic patients. Metabolism, 50(10), 1136-1140
  13. Ito, H., Ohshima, A., Tsuzuki, M., Ohto, N., Yanagawa, M., Maruyama, T., Kaji, Y., Kanaya, S., Nishioka, K. (2001). Effects of inreased physical activity and mild calorie restriction on heart rate variability in obese women. Jpn Heart 1. 42(4), 459-469 https://doi.org/10.1536/jhj.42.459
  14. Jones, P. R. M., Hunt, M. J., Brown, T. P., & Norgan, N. G. (1986). Waist-hip circumference ratio and its relation to age and overweight in British men. Human Nutr Clin Nutr, 40C, 239-247
  15. Liedman, M. (1983). Effect of coarse wheat breat fiber and exercise on plasma lipids and hypoproteins in moderately overweight man. Am J Clin Nutr, 37, 71-81
  16. Lim, H. B., Choi, M. H., & Byun, S. H. (1998). Semilongitudinal changes of physique and obesity of high school students in Kyonggi province. J Korean Public Health Assoc, 24(2), 93-105
  17. Liming Sun, Shun Ishibashi, Jun-ichi Osuga, Kenji Harada, Ken Ohashi, Takanari Gotoda, Yoshihiro Fukuo Yazaki, Nobuhiro Yamada (1998). Clinical features associated with the homozygous Trp64Arg mutation of the $\beta_{3}$-adrenergic receptor. Arterioscler Thromb Vasc Bioi, 18, 941-946
  18. Marzo V, Goparaju S, Wang L, Liu J, Batkai s, Jarai Z, Fezza F, Miura G, Palmiter D, Sugiura T & Kunos G. (2001). Leptin regulated endocarmabinoids are involved in maintaining food .intake. Nature, 410, 822-825
  19. McNaughton, L., & Davies, P. (1987), The effect of a 16 weeks aerobic conditioning program on serum lipids, lipoproteins and coronary risk factors. J Sports Med, 27, 121-130, 296-302
  20. Ministry on Health and Welfare. (2004). '02 The statistics of women health in korea
  21. Morrisom, J. A., Sprecher, D., McMahon, R. P., Simon, J., Schreiber, G. B., & Khoury, P. R. (1996). Obesity and high density lipoprotein cholesterol in black and white 9-and 10 year old girl, The national Heart, Lung and Blood Institute Growth and Healthy Study. Metabolism, 45(4), 469-474
  22. Proenza, A. M., Poissonnet, C. M., Ozata, M., Ozen, S., Guran, S., Palou, A., Strosberg, A. D. (2000). Association of sets of alleles of genes encoding beta3-adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity. Int J Obes Relat Metab Disord, 24(1), 93-100
  23. Seo, H. K., Lee, S. W., Na, J. C., Kang, S. B., Kim, J. M. (1999). The effects of muscle endurance weight training on physical fitness, blood lipid, and lipoprotein in middle-aged women. J Korea society of sports medicine, 17(2), 224-234
  24. Shin, H. J. (1992). The study of obesity in middle school student to a evaluation of needs. Unpublished doctoral dissertation, Korea Sport University
  25. Sung, H. R., Park, S. K. (1999). The effects of aerobic exercise on blood glucose and immune function in NIDDM patients. J Korea society of sports medicine, 17(2), 333-344
  26. Whitehurst, M., & Menendez, E. (1991). Endurance training in older women. Phys. Sportmen, 19, 95-104
  27. Wilmore, J. H., Costill, D. L. (1988). Training for sport and activity. Iowa : Wm. c. Brown Pub.
  28. Wittke, R. (1999). Effect of fluvastatin in combination with moderate endurance training on parameters of lipid metabolism. Sports Med, 27(5), 329-335
  29. Wood, D. D., Haskell, W., Klein, H., & Leis, S. (1976). The distribution of plasma lipoprotein in middle-aged runners. Metabolism, 25(11), 1249-1257
  30. Yook, S. S. (2003). Leptin and insulin response to resistive and aerobic training sessions in middle-aged obese women. The Korea journal of sports science, 12(1), 583-592