The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
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Effects of the Prunus persica Batsch var. davidiana Max. Extract on the Lipid Compositions and Enzyme Activities in Hyperlipidemic Rats

돌복숭아(Prunus persica Batsch var. davidiana Max.) 추출액이 고지혈증 흰쥐의 생체 내 지질성분 및 효소활성에 미치는 영향

  • 김한수 (밀양대학교 생명공학과)
  • Published : 2004.09.01
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Abstract

The purpose of this study was designed to observe the effects of the feeding Prunus persica Batsch var. davidiana Max. extract on the concentrations of the lipids and blood glucose in the S.D. rats fed the experimental diets for 5 weeks. Concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, triglyceride(TG), phospholipid(PL) and blood glucose in serum were significantly higher in the cholesterol administration groups (groups BCG (cholesterol+water), BCPG (cholesterol+ Prunus persica 5.0 g% extract) than those in the control group (group BG, basal diet+water). But the concentrations of total cholesterol, atherosclerotic index, LDL, LDL-cholesterol, free-cholesterol, cholesteryl ester, TG, PL and blood glucose in serum were remarkably lower in the group BCPG than those in the group BCG. In the ratio of HDL-cholesterol concentration to total cholesterol and HDL-cholesterol concentration, Prunus persica 5.0 g% extract administration group was higher percentage than in the group BCG. The activities of aspartate aminotransferase (AST), alanine aminotransferase(ALT), lactate dehydrogenase(LDH) and alkaline phosphatase (ALP) in serum were rather lower in the Prunus persica 5.0 g% extract administration group(group BCPG) than in the cholesterol diet group(group BCG). From the above research, Prunus persica Batsch var. davidiana Max. were effective on the improvement of the blood glucose, lipid compositions in serum of dietary hyperlipidemic rats. And particularly, Prunus persica Batsch var. davidiana Max. was more effective therapeutic regimen for the control of metabolic derangements in adult disease.

돌복숭아(Prunus persica Batsch var. davidiana Max.)의 생리 활성 추출 물질이 생체내 지질 대사 이상 및 각종 질환의 예방과 개선효과 등에 많은 생리적 효능이 있을 것으로 판단되어 실험동물을 통한 혈청 지질개선 작용과 간 기능 효소의 활성 변동등을 구명하기 위해 Sprague Dawley계 숫 흰쥐에 기본 식이만을 급여한 대조군과 돼지 기름, 콜레스테롤 등으로 유발된 고지혈증 군, 고지혈증을 유발한 군에 돌복숭아 5.0 g% 추출액을 각각 급여하여 5주간 실험 사육한 결과, 혈청 총콜레스테롤 농도, 동맥 경화 지수, low density lipoprotein (LDL) 및 LDL-콜레스테롤, 유리 콜레스테롤, 콜레스테롤 에스테르 비, 중성지방, 인지질 농도 및 혈당 농도 등에서 돌복숭아 추출액을 급여하므로서 유의성 있는 농도감소를 나타내었으며, HDL-콜레스테롤 농도 및 총콜레스테롤에 대한 HDL-콜레스테롤의 비는 상승되는 것으로 나타났다. 또한, AST, ALT, LDH 및 ALP활성도 고지혈증 유발군에 돌복숭아 추출액을 급여함으로써 유의적으로 저하되는 것으로 나타났다. 따라서 돌복숭아의 추출액이 지질 대사이상 등에서 모는 각종 성인병의 예방 및 치료 개선 효과가 있을 것으로 사료된다.

Keywords

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