General Perspectives for Molecular Nuclear Imaging

분자핵의학영상 개관

  • Chung, June-Key (Department of Nuclear Medicine, Laboratory of Molecular Imaging and Therapy, Cancer Research Institute, Seoul National University College of Medicine)
  • 정준기 (서울대학교 의과대학 핵의학교실, 암연구소 분자영상치료연구실)
  • Published : 2004.04.30

Abstract

Molecular imaging provides a visualization of normal as well as abnormal cellular processes at a molecular or genetic level rather than at a anatomical level. Conventional medical imaging methods utilize the imaging signals produced by nonspecific physico-chemical interaction. However, molecular imaging methods utilize the imaging signals derived from specific cellular or molecular events. Because molecular and genetic changes precede anatomical change in the course of disease development, molecular imaging can detect early events in disease progression. in the near future, through molecular imaging we can understand basic mechanisms of disease, and diagnose earlier and, subsequently, treat earlier intractable diseases such as cancer, neuro-degenerative diseases, and immunologic disorders. In beginning period, nuclear medicine started as a molecular imaging, and has had a leading role in the field of molecular imaging. But recently molecular imaging has been rapidly developed. Besides nuclear imaging, molecular imaging methods such as optical imaging, magnetic resonance imaging are emerging. Each imaging modalities have their advantages and weaknesses. The opportunities from molecular imaging look bright. We should try nuclear medicine continues to have a leading role in molecular imaging.

Keywords

References

  1. Hadjantonakis A-K, Dickinson ME, Fraser SE, Papaioannou VE. Technicolour transgenics: imaging tools for functional genomics in the mouse. Nat Rev Gene 2003;8:613-25
  2. Massoud TF, Gambhir SS. Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 2003;17:545-80 https://doi.org/10.1101/gad.1047403
  3. Lee KH. Molecular imaging: nuclear medicine technique. J Korean Med Associat 2004;47:119-26 https://doi.org/10.5124/jkma.2004.47.2.119
  4. Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamurthy N, et al. Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci USA 1999;96:2333-8 https://doi.org/10.1073/pnas.96.5.2333
  5. Tjuvajev JG, Avril N, Oku T, Sasajima T, Miyagawa T, Joshi R, et al. Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 1998;58: 4333-41
  6. Liang Q, Satyamurthy N, Barrio JR, Toyokuni T, Phelps MP, Gambhir SS, et al., Noninvasive, quantitative imaging in living animals of a mutant dopamine D2 receptor reporter gene in which ligand binding is uncoupled from signal ransduction. Gene Ther 2001;8:1490-8 https://doi.org/10.1038/sj.gt.3301542
  7. Chung JK, Sodium iodide symporter: Its role in nuclear medicine. J Nucl Med 2002;43:1188-200