Effect of Endurance Training on the Plasma Honocysteine and B Vitamin Levels in Male Adolescent Field Hockey Players

지구력 훈련이 혈중 호모시스테인과 비타민 B 수준에 미치는 영향 -남자 고등학생 필드하키선수를 대상으로-

  • 강해선 (이화여자대학교 생활환경대학 식품영양학과) ;
  • 이명천 (체육과학연구원) ;
  • 유영채 (용산고등학과) ;
  • 장남수 (이화여자대학교 생활환경대학 식품영양학과)
  • Published : 2004.12.01

Abstract

Elevated plasma homocysteine is an independent risk factor for the development of cardiovascular disease. Exercise is generally believed to reduce the plasma homocysteine levels and therefore, being beneficial for cardiovascular disease (CVD). However, there is a possibility that athletes undergoing strenuous training and competition which increase oxidative stress may suffer from increased plasma homocysteine levels. The purpose of this study was to investigate the influence of endurance training on the plasma concentrations of B vitamins and homocysteine in 23 male adolescent field hockey players. Data collection and blood sampling was performed during the training period and non-training period. Following the training period, significant changes in energy and vitamin B6 intakes were observed in these subjects. Plasma vitamin B2, pyridoxal phosphate (PLP) and homocysteine levels were significantly higher during the training period than non-training period, whereas no difference was observed in plasma folate and vitamin B12 levels. Positive correlation was observed between plasma folate and folic acid intakes. When energy, B vitamin intakes were adjusted there was a significant negative correlation between plasma homocysteine levels and plasma riboflavin, folate and vitamin B12 levels. In conclusion, it is suggested that athletes with oxidative stress by strenuous exercise may need B vitamins since riboflavin, folic acid and vitamin Bl2 were shown to be negatively correlated with plasma homocysteine in athletes during the training period.

Keywords

References

  1. Malinow MR. Homocysteine and arterial acclusive diseases. J lnt Med 236: 603-617,1994
  2. Jung DJ, Chung ST. The effect of antioxidants supplementation and exercise intensity on lipid peroxidation. Exercise Science 8(3):423-436,1999
  3. Kanani PM, Sinkey CA, Browning R. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e) inernia in humans. Circulation 100: 1161-1168, 1999 https://doi.org/10.1161/01.CIR.100.11.1161
  4. Wrignt M, Francis K, Cornwell P. Effect of acute exercise on plasma homocysteine. J Sports Med Physi Fitness 38: 262-265, 1998
  5. De Cree C, Whiting PH, Cole H. Interactions between homocyst (e) ine and nitric oxide during acute submaximal exercise in adult maIes. lnt J Sports Med 21: 256-262,2000 https://doi.org/10.1055/s-2000-8884
  6. De Cree C, Malinow MR, van Kranenburg GP, Geurten PG, Longford NT, Keizer HA. Influence of exercise and menstrual cycle phase on plasma homocyst(e) ine levels in young women a prospective study. Scad J Med Sci Sports 9: 272-278, 1999
  7. Steenge GR, Verhoef P, Greenhaff PL. The effect of creatine and resistance training on plasma homocysteine concentration in healthy volunteers. Arch Intern Med 161: 1455-1456, 2001 https://doi.org/10.1001/archinte.161.11.1455
  8. K$\"o$nig D, Biss$\`e$ E, Deibert P, M$\"u$ller HM, Weiland H, Berg A. Influence of training volume and acute physical exercise on the homocysteine levels in endurance-trained men: Interactions with plasma folate and vitamin $B_1_2$. Ann Nutr Metab 47: 114-118, 2003 https://doi.org/10.1159/000070032
  9. Herrmann M, Schorr H, Obeid R, Scharhag J, Urhausen A, Kindennann W, Hemnann W. Homocysteine increases during endurance exercise. Clin Chem Lab Med 41 (11) : 1518-1524, 2002 https://doi.org/10.1515/CCLM.2003.233
  10. Hemnann M, Schorr H, Obeid R, Scharhag J, Urhausen A, Kindermann W, Hemnann W. Comparison of the influence of volume-oriented training and high intensity interval training on serum homocysteine and its cofactors in young, healthy swimmers. Clin Chem Lab Med 41 (11) : 1525-1531, 2003 https://doi.org/10.1515/CCLM.2003.234
  11. Selhub J. Homocysteine metabolism. Annu Rev Nutr 19: 217-246, 1999 https://doi.org/10.1146/annurev.nutr.19.1.217
  12. Skoupy S, Fodinger M, Veitl M, Perschk A, Puttinger H, Rohrer C, Schindler K, Vychytil A, Horl WH, Sunder-Plassmann G. Riboflavin is a determinant of total homocysteine plasma concentration in end-stage renal disease patients. J Am Soc Nephrol 13: 1331-1337, 2002 https://doi.org/10.1097/01.ASN.0000013299.11876.F6
  13. Suzanne LC, Xhignesse M, Piolot A, Selhub J, Davignon J, Genest J. Jr. Plasma total homocysteine in healthy subjects: sexspecific relation with biological traits. Am J Clin Nutr 64: 587-593, 1996
  14. Hyun TS, Han YH. Comparison of folate intake and food sources in college students using the 6th vs. 7th nutrient database. Kor J Nutr 34 (7) : 797-808, 2001
  15. The contents of vitamin $B_6$, pantothenic acid, vitamin $B_1_2$, , folate, vitamin D, vitamin E, vitamin K in food, 6th revision. Rural Development Administration, 2002
  16. Recommended Dietary Allowances for Koreans, 7th revision. The korean Nutrition Society, Seoul, 2000
  17. Capo-Chichi CD, Gueant JL, Lefebvre E, Bennani N, Lorentz E, Vidailhet C, Vidaihet M. Riboflavin and riboflavin-derived cofactors in adolescent girls with anorexia nervosa. Am J Ciin Nutr 69: 672-678, 1999
  18. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromato 422: 43-52, 1987 https://doi.org/10.1016/0378-4347(87)80438-3
  19. Neuhaus D, Geahtgens P. Haemorrheology and long term exercise. Sports Med 18: 10-21, 1994 https://doi.org/10.2165/00007256-199418010-00003
  20. Crozier PG, Cordain L, Sampson DA. Exercise-induced changes in plasma vitamin $B_6$ concentrations do not vary with exercise intensity. Am J Clin Nutr 60: 552-558, 1994
  21. Leklem JE, Shultz TD. Increased plasma pyridoxal 5'-phosphate and vitamin $B_6$ in male adolescents after a 4500-meter run. Am J Clin Nutr 38: 541-548, 1983
  22. Vrrk R, Dunton N, Leklem J. The effect of vitamin $B_6$ supplementation on fuel utilization during exhaustive exercise. FASEB J 6: A1374 (abstr), 1992
  23. Ahn HS, Chang NS. Studies on plasma homocysteine concentration and nutritional status of vitamin $B_6$, $B_1_2$ and folate in college women. Korean J Nutrition 35 (1) : 37-44, 2002
  24. Kang MW, Chang NS. Effect of dietary folate intakes on serum folate levels of pregnant and lactating women. Korean J Nutrition 26(4): 433-442,1993