Journal of the Korean Ceramic Society (한국세라믹학회지)

The Korean Ceramic Society (한국세라믹학회)
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Surface dissolution of Hydroxyapatite Biomaterials with Ca/P Ratio

Ca/P 비에 따른 수산화아파타이트 생체재료의 표면용해 특성

  • Seo, Dong-Seok (School of Materials Science and Engineering, Seoul National University) ;
  • Kim, Hwan (School of Materials Science and Engineering, Seoul National University) ;
  • Lee, Jong-Kook (Department of Advanced Materials Engineering, Chosun University)
  • 서동석 (서울대학교 재료공학부) ;
  • 김환 (서울대학교 재료공학부) ;
  • 이종국 (조선대학교 신소재공학과)
  • Published : 2004.01.01
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Abstract

Hydroxyapatite (HA) ceramics with the Ca/P ratios of 1.62, 1.67 and 1.72 were prepared and their dissolution behaviors in distilled water at $37^{\circ}C$ were investigated. It appeared that surface dissolution of the ceramics was initiated from grain boundaries after 3 days of immersion in water. Following 10 days of immersion, microstructural disintergration of HA was severs for non-stoichiometric compounds, I.e Ca/P ratios of 1.62 and 1.72. Notably, a micron-sized circular cavity similar to lacunae, which can be generally formed in osteoclastic resorption process, was observed.

Ca/P 비가 각각 1.62, 1.67, 1.72인 수산화아파타이트(Hydroxyapatite, HA) 세라믹스를 제조하고, HA 표면에서 수용액에 의하여 일어나는 용해현상을 고찰하였다. 수용액에서 3일간 침적시킨 경우 입계에서부터 용해가 시작되었으며, 침적시간이 10일로 증가하면서 이러한 입계용해에 의한 HA 세라믹스의 미세구조적 분해 현상은 비화학양론적 조성, 즉 Ca/P 비가 1.62 또는 1.72인 시편에서 두드러지게 나타났다. 주목할만한 것은, 용해가 진행되는 동안 세라믹스의 표면에는 골식세포의 흡수 과정에서 흔히 볼 수 있는 표면 결함(lacunae)과 매우 유사한 모양을 갖는 원형의 빈 공간(cavity)이 형성되었다.

Keywords

References

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