The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Defensive Effect of Samooltang on Injury of Gastric Mucous Membrane of Mouse by Ethanol

알코올로 유발된 생쥐의 위점막손상에 대한 사물탕의 보호효과

  • Lee Seong-Hwan (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lim Seong-Woo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University)
  • 이성환 (동국대학교 한의과대학 내과학교실) ;
  • 임성우 (동국대학교 한의과대학 내과학교실)
  • Published : 2004.09.01
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Abstract

Objectives : This study was carried out to investigate the effect of Samooltang (SMT) on the injury of gastric mucous membrane by ethanol in mice. Methods : The normal group was mice with no inflammation. The control group was mice with gastro-inflammation elicited by ethanol. The sample group was SMT-administered mice before gastro-inflammation elicitation. Results : In the immunohistochemical change, the distribution of SBA and COX-1 treated with SMT noticeably increased over the control group (p<0.05). The distribution of NF-κB P50, COX-2, and TUNEL treated with SMT noticeably decreased over the control group (p<0.05). The distribution of SMT was the same as the normal group. Conclusions : According to the above results, it is supposed that SMT would be helpful against gastritis and gastric ulcer caused by alcoholic drinks.

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