Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Ginsan Improved Th1 Immune Response Inhibited by Gamma Radiation

  • Han Seon Kyu (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences, Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology) ;
  • Song Jie Young (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences) ;
  • Yun Yeon Sook (Laboratory of Immunology, Korea Institute of Radiological and Medical Sciences) ;
  • Yi Seh Yoon (Technical Research Institute, Microbia Corp, College of Natural Science, Suwon University)
  • Published : 2005.03.01
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Abstract

Gamma radiation causes suppression of the immune function, and immune properties are related to cytokine production. In the present study, the polysaccharide, Ginsan, purified from an ethanol-insoluble fraction of Ginseng (Panax ginseng C.A. Meyer, Araliaceae) water extract was studied to assess its effects on the immunosuppressive activities of gamma radiation. Gin­san was found to stimulate murine normal splenocytes by inducing the mRNA expressions of Th1 and Th2 type cytokines, and also restore the mRNA expression of IFN-$/gamma$, Th1 cytokine, after its inhibition by whole-body gamma irradiation. Therefore, Ginsan was found to restore the T lymphocytes function that had been suppressed by gamma irradiation in allogenic MLR (mixed lymphocyte reactions). However, Ginsan exhibited no excessive stimulatory effects on the control group. The above results indicated that Ginsan may constitute a new noble agent for the improvement of gamma radiation-induced immunosuppression.

Keywords

References

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