Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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The Relationship between Urinary 8-hydroxydeoxyguanosine and Polycyclic Aromatic Hydrocarbons Exposure in Working Environment

  • Lee Jong-Seong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Kim Eun-A (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Lee Yong-Hag (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency) ;
  • Moon Deog-Hwan (Institute of Industrial Medicine and Department of Occupational & Environmental Medicine, Inje University Paik Hospital) ;
  • Kim Kwang-Jong (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
  • Published : 2005.06.01
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Abstract

To investigate the exposure effect of polycyclic aromatic hydrocarbons (PAHs), we analyzed the relationship between urinary 8-hydroxydeoxyguanosine (8-OHdG) concentration and PAHs exposure. The study population contained 44 workers in steel-pipe coating and paint manufacture industries. We measured airborne total PAHs as an external dose, urinary 1-hydroxypyrene (1-OHP) as an internal dose of PAHs exposure, and urinary 8-OHdG as an effective dose of oxidative DNA damage. There was significant correlation between the urinary concentration of l-OHP and the environmental concentration of PAHs, pyrene, urinary cotinine, AST, and GGT. The mean of urinary 8-OHdG was $17.07\pm1.706{\mu}g/g$ creatinine in workers exposed to airborne PAHs. There was significant correlation between the urinary concentration of 8-0HdG and the airborne concentration of PAHs. From the results of stepwise multiple regression analysis about 8-OHdG, significant independents was total PAHs. In this study, there were significant correlation between the urinary concentration of 8-OHdG and the airborne concentration of PAHs. The urinary 1-OHP was effective index as a biomarker of airborne PAHs in workplace. But it was influenced by non-occupational PAHs source, smoking and biomarkers of liver function test.

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