The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Anti-inflammatory Effect of Alpiniae officinari Rhizoma Extract

고량강의 항염증 작용에 대한 연구

  • Park, Hi-Joon (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Lee, Je-Hyun (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Kim, Su-Young (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Shim, Bum-Sang (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Ku, Heon-Jong (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Kang, Jun-Mo (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Choe, Il-Hwan (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Lee, Jae-Dong (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Kim, Nam-Jae (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Lee, Ji-Suk (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University) ;
  • Lim, Sa-Bi-NA (Research Group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute. Kyung Hee University)
  • 박히준 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 이제현 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 김수영 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 심범상 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 구헌종 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 강전모 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 최일환 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 이재동 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 김남재 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 이지숙 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 임사비나 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀)
  • Published : 2005.06.30
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Abstract

Objective : The use of herbal therapy is becoming an increasingly attractive approach for the treatment of various inflammatory disorders. The Alpiniae officinari Rhizoma is popular in Aisa as a traditional herbal medicine. Alpiniae officinari Rhizoma is a species of the ginger family(Zingiberacease). Method : This study was performed to investigate the anti-inflammatory effect of Alpiniae officinari Rhizoma extract by the methods of 'carrageenan induced paw edema' and 'Lipopolysaccharide-induced inflammatory mediators in mouse macrophage RAW 264.7 cells'. Result : We suggest that Alpiniae officinari Rhizoma extract decreased paw volume induced by plantar injection of carrageenan. Also Alpiniae officinari Rhizoma extract inhibited nitric oxide, prostaglandin $E_2$ production and induced nitric oxide synthase, cyclooxygenase-2 protein expression in Mouse macrophage RAW 264.7 cells stimulated with lipopolysaccharide. Conclusion : This study shows that Alpinia officinari Rhizoma extract seems to have anti-inflammatory effect by inhibition of nitric oxide, prostaglandin $E_2$ production and nitric oxide synthase, cyclooxygenase-2 protein expression.

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