The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지

The experimental Studies on the immunomodulational effects of Lonicerae Caulis et Folium -the effects of Lonicerae Caulis et Folium on cytokines production in mice splenocytes-

인동등(忍冬藤)의 면역조절작용(免疫調節作用)에 대한 실험적(實驗的) 연구(硏究)(II) -인동등(忍冬藤) 각 fraction이 mice 비장세포에서 cytokines 생성에 미치는 영향-

  • Lee, Young-Cheol (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Kwon, Taek-Hyun (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Ok, In-Soo (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Seo, Chang-Woo (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Kim, Yang-Jin (Department of Herbology, College of Oriental Medicine, Sangji University) ;
  • Roh, Seong-Soo (Department of Herbology, College of Oriental Medicine, Daejeon University) ;
  • Seo, Young-Bae (Department of Herbology, College of Oriental Medicine, Daejeon University)
  • 이영철 (상지대학교 한의과대학 본초학교실) ;
  • 권택현 (상지대학교 한의과대학 본초학교실) ;
  • 옥인수 (상지대학교 한의과대학 본초학교실) ;
  • 서창우 (상지대학교 한의과대학 본초학교실) ;
  • 김양진 (상지대학교 한의과대학 본초학교실) ;
  • 노성수 (대전대학교 한의과대학 본초학교실) ;
  • 서영배 (대전대학교 한의과대학 본초학교실)
  • Published : 2005.12.30
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Abstract

In order to investigate the immunomodulational effects of Lonicerae Caulis et Folium, the author measured cytokines production(IL-10, IL-12(P35), IL12(P40), $IFN-{\gamma}$) in mice splenocytes. The results were obtained as follows : 1. The water extract of Lonicerae Caulis et Folium significantly enhanced the gene expression of IL-12(P35), IL-12(P40), but reduced the gene expression of IL-10, $IFN-{\gamma}$. 2. In water fraction and ethyl acetate fraction, the gene expression of IL-12(P35), $IFN-{\gamma}$ was significantly increased and that of IL-12(P40), IL-10 was decreased. The above results demonstrate that Lonicerae Caulis et Folium has enhancing immune activity by upregulation of these cytokines. Therefore, if we make the relationship between these cytokines(IL-10, IL-12, $IFN-{\gamma}$) besides IL-1, IL-4, IL-6, $TNF-{\alpha}$, IL-8, $TGF-{\beta}$ and so on which concerned the immunopotentiation, the immunopotentiational mechanism of Lonicerae Caulis et Folium will be shown clearly.

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