Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
권호 표지

Effect of Bopheyangyoungjeon on the Lung Tumor of A/J Mouse Induced with Urethane

보폐양영전(保肺養營煎)이 Urethane으로 유발(誘發)된 A/J mouse의 폐암에 미치는 영향(影響)

  • Seo, Chul-Hoon (Dept. of Oriental Medicine Graduate School of Dongshin University) ;
  • Kim, Hee-Chul (Dept. of Oriental Medicine Graduate School of Dongshin University)
  • 서철훈 (동신대학교 한의과대학 내과학교실) ;
  • 김희철 (동신대학교 한의과대학 내과학교실)
  • Published : 2005.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

A/J mice injected with urethane(1mg/ g of body weight) develop tumors with distinct histological patterns, which are classified as solid and papillary. I divided the mice into 3 groups; control group treatment with saline, BYA group treatment with herbal formula, Bopheyangyoungjeon 0.3g/kg and BYB groups treatment with herbal formula 1.5g/kg. The administration of herbal medicine was done every day for 56 days. The experimental results from herbal medicine treatment were compared to those from a saline-treated control group. Serial sections of the whole lung(150 to 200 sections per mouse) showed solid and papillary tumors arose from the pulmonary acinus, invading the bronchioles only as the tumors grew. The number of tumor, in the 8-weeks groups, are decreased in the experimental groups compared to control group. COX-2 protein and IGF- I protein expression was more increased in lung tumors of the control group compared to BYA and BYB groups. These results suggest that Bopheyangyoungjeon extract suppress the carcinogenesis of lung in the A/J mouse.

Keywords