Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Antibacterial and antioxidant activities of three Turkish species of the genus Centaurea

  • Sarker, Satyajit Dey (Pharmaceutical Biotechnology Research Group, School of Biomedical Sciences, University of Ulster at Coleraine) ;
  • Kumarasamy, Yashodharan (School of Pharmacy, The Robert Gordon University) ;
  • Shoeb, Mohammad (School of Pharmacy, The Robert Gordon University) ;
  • Celik, Sezgin (Department of Biology, Faculty of Science and Literature, 18 Mart University) ;
  • Eucel, Ersin (Department of Biology, Faculty of Science, Anadolu University) ;
  • Middleton, Moira (School of Pharmacy, The Robert Gordon University) ;
  • Nahar, Lutfun (School of Life Sciences, The Robert Gordon University)
  • Published : 2005.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

A number of species of the genus Centaurea (Family: Asteraceae), distributed in various parts of Asia, Europe and North America, have been used in traditional plant-based medicine and reported to possess various medicinal properties. As part of our continuing evaluation of plants from the genus Centaurea for their phytochemistry and biological activities, the dichloromethane (DCM) and methanol (MeOH) extracts of the seeds of Turkish Centaurea species, C. bornmuelleri, C. huber-morathii and C. schiskinii, were screened for antioxidant and antibacterial activities. Among the three species, C. huber-morathii displayed the most prominent antibacterial activity. Both the MeOH and DCM extracts of this plant showed activity against Citrobacter freundii, Enterococcus faecalis and Salmonella goldcoast with the MIC values within the range of $1\;{\times}\;10^{-2}\;to\;1\;{\times}\;10^{-3}\;mg/ml$. The MeOH extract of C schiskinii showed activity $(MIC\;=\;1\;{\times}\;10^{-1}\;mg/ml)$ against Citrobacter freundii and Staphylococcus aureus. While the DCM extract of C. bornmuelleri was only active against Staphylococcus aureus $(MIC\;=1\;{\times}\;10^{-2}\;mg/ml)$, the MeOH extract did not show any inhibitory activity at test concentrations. The DCM and MeOH extracts of all three species demonstrated good degree of antioxidant property in the DPPH assay with the $RC_{50}$ values ranging from $72\;{\times}\;10^{-2}\;to\;31{\times}\;10^{-3}\;mg/ml$. Among these extracts, the MeOH extract of C. hubermorathii was the most active antioxidant extract $(MlC\;=\;31\;{\times}\;10^{-3}\;mg/ml)$.

Keywords

References

  1. Clapham AR, Tutin TG, Warburg EF. (1952) Flora of the British Isles. Cambridge University Press, UK.
  2. Cooper G, Laird A, Nahar L, Sarker SD. (2002) Lignan glucosides from the seeds of Centaurea americana (Compositae). Biochem. Syst. Ecol. 30, 65-67. https://doi.org/10.1016/S0305-1978(01)00062-X
  3. Drummond AJ, Waigh RD. (2000) In 'Recent Research Developments in Phytochemistry' vol. 4 (Pandalai SG, ed.), pp. 143-152, Research Signpost, India.
  4. Ferguson CA, Nahar L, Finnie D, Kumarasamy Y, Reid R, Mir-Babayev NF, Sarker SD. (2003) Centaurea scabiosa: A source of dibenzylbutyrolactone lignans. Biochem. Syst. Ecol. 31, 303-305. https://doi.org/10.1016/S0305-1978(02)00143-6
  5. Grieve M. (2002) A Modern Herbal. Available on-line at-http://botanical.com/botanical/mgmh/c/centau46.html
  6. GRIN database. (2005) USDA, ARS, National Genetic Resources Program, Germplasm Resources Information Network - (GRIN), National Germplasm Resources Laboratory, Beltsville, Maryland, USA. Available on-line at: http://www.ars-grin.gov/cgi-bin/npgs/html/genus.pl?2232
  7. Kumarasamy Y, Nahar L, Cox PJ, Dinan LN, Ferguson CA, Finnie D, Jaspars M, Sarker SD. (2003a) Biological activities of lignans from Centaurea scabiosa. Pharm. Biol. 41, 203-206. https://doi.org/10.1076/phbi.41.3.203.15099
  8. Kumarasamy Y, Middleton M, Nahar L, Sarker SD. (2003b) Bioactivity of indole alkaloids from the seeds of Centaurea nigra. Fitoterapia, 74, 609-612. https://doi.org/10.1016/S0367-326X(03)00144-8
  9. Kumarasamy Y, Fergusson M, Nahar L, Sarker SD. (2002) Biological activity of moschamindole from Centaurea moschata. Pharmaceutical. Biol. 40, 307-310. https://doi.org/10.1076/phbi.40.4.307.8467
  10. Lorian V. (1991) Antibiotics in Laboratory Medicine, 3rd edition, William and Wilkins, Baltimore, USA.
  11. Middleton M, Cox PJ, Jaspars M, Kumarasamy Y, Nahar L, Reid R, Sarker SD. (2003) Dibenzylbutyrolactone lignans and indole alkaloids from the seeds of Centaurea nigr., Biochem. Syst. Ecol. 31, 653-656. https://doi.org/10.1016/S0305-1978(02)00227-2
  12. Phytochemical and Ethnobotanical databases. (2005) USDA, ARS, Beltsville Agricultural Research Center, Beltsville, Maryland, USA. Available on-line at: http://www.ars-grin.gov/cgi-bin/duke/ethnobot.pl
  13. Ribeiro NL, Nahar L, Kumarasamy Y, Mir-Babayev N, Sarker SD. (2002) Flavonoid C-glucosides and a lignan from Centaurea macrocephala (Compositae). Biochem. Syst. Ecol. 30, 1097-1100. https://doi.org/10.1016/S0305-1978(02)00046-7
  14. Sarker SD, Eynon E, Fok K, Kumarasamy Y, Murphy EM, Nahar L, Shaheen EM, Shaw NM, Siakalima M. (2003) Screening the extracts of the seeds of Achillea millefolium, Angelica sylvestris and Phlegm pratense for antibacterial, antioxidant and general toxicity. Orient. Pharm. Exp. Med. 3, 157-162. https://doi.org/10.3742/OPEM.2003.3.3.157
  15. Sarker SD, Laird A, Nahar L, Kumarasamy Y, Jaspars M. (2001) Indole alkaloids from the seeds of Centaurea cyanus (Asteraceae). Phytochemistry 57, 1273-1276. https://doi.org/10.1016/S0031-9422(01)00084-X
  16. Sarker SD, Dinan L, Sik V, Underwood E, Waterman PG. (1998a) Moschamide: an unusual alkaloid from the seeds of Centaurea moschata. Tetrahedron Lett. 39, 1421-1424. https://doi.org/10.1016/S0040-4039(97)10818-8
  17. Sarker SD, Sik V, Dinan L, Rees HH. (1998b) Moschatine: An unusual steroidal glycoside from Centaurea moschata. Phytochemistry 48, 1039-1043. https://doi.org/10.1016/S0031-9422(97)01038-8
  18. Sarker SD, Girault J-P, Lafont R, Dinan L. (1998c) (20R) $15{\alpha}-Hydroxy-8{\beta},9a,14{\alpha},17{\alpha}-pregn-4-en-3-one20-O-{\beta}-D-glucopyranoside$ from Centaurea moschata. Pharm. Biol. 36, 202-206. https://doi.org/10.1076/phbi.36.3.202.6346
  19. Sarker SD, Savchenko T, Whiting P, Sik V, Dinan LN. (1997a) Moschamine, cis-moschamine, moschamindole and moschamindolol: four novel indole alkaloids from Centaurea moschata. Nat. Prod. Lett. 9, 189-199. https://doi.org/10.1080/10575639708048314
  20. Sarker SD, Savchenko T, Whiting P, Sik V, Lafont R, Dinan L. (1997) Occurrence of ecdysteroids in the genus Centaurea: 20-hydroxy ecdysone from Centaurea moschata. Biochem. Syst. Ecol. 25, 367-368. https://doi.org/10.1016/S0305-1978(97)00018-5
  21. Shoeb M, Rahman MM, Nahar L, Jaspars M, MacManus S, Delazar A and Sarker SD. (2004) Bioactive lignans from the seeds of Centaurea macrocephala. DARU 12, 87-93.
  22. Shoeb M, Jaspars M, MacManus SM, Majinda RRT, Sarker SD. (2004) Epoxylignans from the seeds of Centaurea cyanus. Biochem. Syst. Ecol. 32, 1201-1204. https://doi.org/10.1016/j.bse.2004.03.011
  23. Takao T, Watanabe N, Yagi I, Sakata K. (1994) A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish. Biosci. Biotech. Biochem. 58, 1780-1783. https://doi.org/10.1271/bbb.58.1780

Cited by

  1. Antioxidant capacity and fatty acid profile of Centaurea kotschyi (Boiss. & Heldr.) Hayek var. persica (Boiss.) Wagenitz from Turkey vol.62, pp.1, 2011, https://doi.org/10.3989/gya.056010