The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Clinical Study of the Efficacy and. Safety of Jetongdan on Patients with Osteoarthritis of the Knee

퇴행성 슬관절염에 대한 제통단의 안전성과 효능 임상연구

  • Seo Byung-Kwan (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University) ;
  • Ryu Seong-Ryong (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University) ;
  • Kang Jung-Won (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University) ;
  • An Kyungeh (East-West Medical Research Institute, Kyung Hee University) ;
  • Lee Sang-Hoon (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University) ;
  • Choi Do-Young (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University) ;
  • Kim Keon-Sik (Department of Acupuncture & Moxibustion, Kyung Hee University) ;
  • Lee Doo-Ik (Department of Acupuncture & Moxibustion, Kyung Hee University) ;
  • Lee Yun-Ho (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University) ;
  • Lee Jae-Dong (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Kyung-hee University)
  • 서병관 (경희대학교 한의과대학 침구학교실) ;
  • 류성룡 (경희대학교 한의과대학 침구학교실) ;
  • 강중원 (경희대학교 한의과대학 침구학교실) ;
  • 안경애 (경희대학교 동서의학연구소) ;
  • 이상훈 (경희대학교 한의과대학 침구학교실) ;
  • 최도영 (경희대학교 한의과대학 침구학교실) ;
  • 김건식 (경희대학교 의과대학 마취통증의학과학교실) ;
  • 이두익 (경희대학교 의과대학 마취통증의학과학교실) ;
  • 이윤호 (경희대학교 한의과대학 침구학교실) ;
  • 이재동 (경희대학교 한의과대학 침구학교실)
  • Published : 2005.06.01
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Abstract

Objectives: In order to investigate the efficacy and safety of the newly developed herbal medicine Jetongdan, a placebo­controlled, randomized clinical trial of patients with osteoarthritis of the knee was undertaken. Methods: Data were obtained from 80 patients with OA of the knee. After enrollment, they were asked to answer a disease-specific questionnaire (Western Ontario and McMaster Universities (WOMAC) OA index) and analyzed with the erythrocyte sedimentation rate (ESR) in order to evaluate the efficacy of Jetongdan, and analyzed for aspartate transaminase (AST) level, alanine transaminase (ALT) level, blood mea nitrogen (BUN) level, and creatinine (Cr) level in order to evaluate the safety of Jetongdan. Results: The liver function and renal function did not deteriorate after treatment with Jetongdan. Composite WOMAC score and physical function subscale was improved, but pain subscale, stiffness subscale, and ESR were not improved by. This was possibly because the baseline characteristics of the two groups were not homogenized after randomization. Conclusions: Jetongdan could be a promising treatment option for osteoarthritis of the knee. Further study in a larger population with appropriate severity grades is recommended.

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