Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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Bacterial $\beta$-Glucan Exhibits Potent Hypoglycemic Activity via Decrease of Serum Lipids and Adiposity, and Increase of UCP mRNA Expression

  • HONG KYUNGHEE (Asan Institute for Life Science) ;
  • JANG KI-HYO (Department of Food and Nutrition, Samcheok National University) ;
  • LEE JAE-CHEOL (Department of Food and Nutrition, Samcheok National University) ;
  • KIM SOHYE (Health Medical Center, Seoul National University Bundang Hospital) ;
  • KIM MI-KYOUNG (DawMaJin Biotechnology Research Institute, DMJ Biotech Corp.) ;
  • LEE IN-YOUNG (DawMaJin Biotechnology Research Institute, DMJ Biotech Corp.) ;
  • KIM SANG-MOO (Faculty of Marine Bioscience and Technology, Kangnung National University) ;
  • LIM YOONG HO (Department of Molecular Biotechnology, Bio/Molecular Informatics Center, Konkuk University) ;
  • KANG SOON AH (Department of Molecular Biotechnology, Bio/Molecular Informatics Center, Konkuk University)
  • Published : 2005.08.01
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Abstract

This study was undertaken to evaluate the effect of bacteria-derived $\beta$-glucan fiber on serum lipids, adiposity and uncoupling protein (UCP) expression in rats. In order to induce obesity, Sprague-Dawley weanling male rats were allowed free access to AIN-76A diet until 4 weeks of age, and fed high-fat diet (beef tallow, $40\%$ of calories as fat) for 6 weeks until 10 weeks of age. Rats were then fed with $0\%$ thigh- fat control group), $1\%$, or $5\%$ bacterial ~-glucan supplemented high-fat diets (w/w) for another 6 weeks. For comparison, normal control group was fed with AIN-76 diet $11.7\%$ fat). Supplementation with bacterial $\beta$-glucan resulted in a significant reduction of high-fat-induced white fat (i.e., visceral and peritoneal fat) development, adipocyte hypertrophy, and development of hyperinsulinemia and hyperleptinemia. Serum triglyceride, total cholesterol, and free fatty acid levels were greatly reduced, but, HDL-cholesterol concentrations were increased by bacterial $\beta$-glucan supplementation. Serum leptin level was lower in the $\beta$-glucan groups than in the high-fat group. The expression of UCPs (UCP1, UCP2, and UCP3) in brown adipose tissue (BAT) were significantly increased by $5\%$ bacterial $\beta$-glucan-containing diet. This study suggests that the anti-obesity effect of $5\%$ bacterial $\beta$-glucan is attributed to upregulation of UCPs and inefficient energy utilization.

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References

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