Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Study of Dietary Fatty acids, Blood Fatty Acid Composition, and Immune Parameters in Atopic Dermatitis Patients

아토피 피부염 환자의 지방산 섭취와 혈중 지방산 조성 및 면역 지표에 관한 연구

  • Chung Yun Mi (Department of Medical Nutrition, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Kim Sujung (Department of Medical Nutrition, Graduate School of East-West Medical Science Kyung Hee University) ;
  • Kim Nack-In (Department of Dermatology, College of Medicine, Kyung Hee University) ;
  • Lee Eun-Young (Research Institute of Clinical Nutrition, Kyung Hee University) ;
  • Choue Ryowon (Department of Medical Nutrition, Graduate School of East-West Medical Science Kyung Hee University, Research Institute of Clinical Nutrition)
  • 정윤미 (경희대학교 동서의학대학원 의학영양학과) ;
  • 김수정 (경희대학교 동서의학대학원 의학영양학과) ;
  • 김낙인 (경희대학교 의과대학 피부과학교실) ;
  • 이은영 (경희대학교 임상영양연구소) ;
  • 조여원 (경희대학교 동서의학대학원 의학영양학과, 경희대학교 임상영양연구소)
  • Published : 2005.09.01
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Abstract

The prevalence of atopic dermatitis (AD) continues to rise in industrialized countries related to Western lifestyle, including dietary habits, especially imbalance of intake of dietary fatty acids. The purpose of this study was to evaluate the dietary fatty acids and the assess the blood fatty acid composition and immune parameters in AD patients. AD (n = 50) patients and gender ${\cdot}$ age matched healthy controls (HC) were studied in case-control clinical trail. Current fatty acids intake status was determined by 3-day food record method. Blood sample were collected from 30 subjects in each group and blood fatty acid composition and immune parameters were analysed. AD patients consumed less PUFA and their n-6/n-3 PUFA ratio was higher than that of HC. Both the ratios of PUFA and MUFA were positively correlated with SCORAD in AD patients (p < 0.05). In the AD patients, there were abnormalities in the fatty acid composition of the RBC and WBC, SFA being significantly high and most n-3 PUFA being significantly low. Moreover, both the ratios of EPA and DHA in WBC were negatively correlated with dietary n-6/n-3 PUFA ratio in AD patients (p < 0.05). Serum total IgE and IL-4 levels of AD patients increased significantly compared with the levels of HC (p < 0.01). Ratios of monocyte and eosinophil in WBC of AD patients increased significantly compared with the levels of HC including total WBC count (p < 0.01), and ratios of Iymphocyte and basophil in WBC of AD patients decreased significantly compared with the levels of HC (p < 0.05). Moreover, the ratios of eosinophil in WBC were positively correlated with dietary P/M ratio (p < 0.05), and the ratios of monocyte in WBC were positively correlated with n-6/n-3 PUFA ratio (p < 0.05) in AD patients. This results indicated that AD patients had significantly high intake of dietary n-6/n-3 PUFA compared with HC. Imbalance of intake of dietary fatty acids affected fatty acid compositions in the RBC and WBC, and these lead to immune imbalance and grow worse of AD.

Keywords

References

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