Journal of environmental and Sanitary engineering (환경위생공학)

Korean Society for Environmental Sanitary Engineers (대한환경위생공학회)
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Effect of Chestnut Bark Extracts on Tyrosinase Gene Expression

율피 추출물이 티로시나아제 유전자 발현에 미치는 효과

  • Chin Jong-Eon (Dept. of Cosmetology, Dongkang College) ;
  • Kim Kwan-Chun (Dept. of Enviromental Administration, Gwangju Health College)
  • 진종언 (동강대학 피부미용과) ;
  • 김관천 (광주보건대학 환경행정과)
  • Published : 2005.09.01
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Abstract

Chestnut bark extract by methanol repressed the expression of tyrosinase gene of B16 mouse melanoma cell containing tyrosinase promoter. $10{\mu}g/ml{\ell}\;100{\mu}g/m{\ell}$, $1mg/m{\ell}$ of the extract repressed expression of tyrosinase gene about $38\%,\;47\%,\;and\;78\%$, respectively, compared with control. In the MTT assay, the same extract exhibited very low cytotoxicity at $1{\mu}g/m{\ell},\;10{\mu}g/m{\ell},\;100{\mu}g/m{\ell},\;and\;1mg/m{\ell}$, respectively. The fractions of Methylene chloride and ethyl acetate did not showed the repressive effect on the expression of tyrosinase gene, but the fraction of butyl alcohol repressed highly at $10{\mu}g/m{\ell}\;and\;100{\mu}g/m{\ell}$.

Keywords

References

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