Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effects of Methanolic Extract of Angelicae koreana Radix against Benzo$(\alpha)pyrene$ Induced Liver Injury in Rats

Benzo$(\alpha)pyrene$에 의해 유도된 흰쥐의 간 장해에 미치는 강활 Methanol 추출물의 효과

  • Yoon Soo-Hong (Dept. of Pharmacy, Catholic University of Taegu) ;
  • Ha Hun (Dept. of Pharmacy, Sangrok Hospital)
  • 윤수홍 (대구가톨릭대 약학과) ;
  • 하헌 (상록병원 약제과)
  • Published : 2005.10.01
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Abstract

To evaluate the preventive effects of methanolic extract of Angelica koreana(MEAK), this extract was given to rats orally at various doses of 10, 50 and 100 mg/kg before hepatotoxicant, benzo$(\alpha)pyrene$ treatment The increased serum enzyme levels of aspartate aminotransferase (AST), alanine aminotransferase(ALT) and alkaline phosphatase(ALP) by benzo$(\alpha)pyrene$ induction were significantly lowered in a dose dependent manner after pretreatment with MEAK. Furthermore, MEAK also decreased the elevated lipid levels after benzo$(\alpha)pyrene$ administration. These results revealed that MEAK could afford a significant protective action in the alleviation of benzoBenzo$(\alpha)pyrene$ induced hepatocellular injury.

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