Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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New Cytotoxic Benzopyrans from the Leaves of Mallotus apelta

  • Kiem Phan Van (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology) ;
  • Dang Nguyen Hai (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology) ;
  • Bao Ha Viet (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology) ;
  • Huong Hoang Thanh (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology) ;
  • Minh Chau Van (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology) ;
  • Huong Le Mai (Institute of Natural Products Chemistry, Vietnamese Academy of Science and Technology) ;
  • Lee Jung Joon (Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim Young Ho (College of Pharmacy, Chungnam National University)
  • Published : 2005.10.01
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Abstract

Two new benzopyrans 6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7 -dimethoxy-2,2-dimethyl-2H-1-ben-zopyran (1) and 6-[1'-oxo-3'(R)-methoxy-butyl]-5,7 -dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, $IC_{50}\;:\;0.49\;{\mu}g/mL$) and rhabdosarcoma (RD, $IC_{50}\;:\;0.54\;{\mu}g/mL$), while compound 2 showed moderate activity against Hep-2 cell line ($IC_{50}\;:\;4.22\;{\mu}g/mL$) by in vitro assay.

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References

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