Change of Ginsenoside Composition in Ginseng Extract by Vinegar Process

  • Published : 2005.08.30

Abstract

The purpose of this study was to develop a new preparation process of ginseng extract using high concentrations of ginsenoside $Rg_3$, a special component in red ginseng. From when the ginseng saponin glycosides transformed into the prosapogenins chemically, they were analyzed using the HPLC method. The ginseng and ginseng extract were processed with several treatment conditions of an edible brewing vinegar. The results indicated that ginsenoside $Rg_3$ quantities increased over 4% at the pH 2-4 level of vinegar treatment. This occurred at temperatures above $R90^{\circ}C$, but not occurred at other pH and temperature condition. In addition, the ginseng and ginseng extract were processed with the twice-brewed vinegar (about 14% acidity). This produced about 1.5 times more ginsenoside $Rg_3$ than those processed with regular amounts of brewing vinegar (about 7% acidity) and persimmon vinegar (about 3% acidity). Though the white ginseng extract was processed with the brewing vinegar over four hr, there was no change for ginsenoside $Rg_3$. However, the VG8-7 was the highest amount of ginsenoside $Rg_3$ (4.71%) in the white ginseng extract, which was processed with the twice-brewed vinegar for nine hr. These results indicate that ginseng treated with vinegar had 10 times the quantity of ginsenoside $Rg_3$, compared to the amount of ginsenoside $Rg_3$ in the generally commercial red ginseng, while ginsenoside $Rg_3$ was not found in raw and white ginseng.

Keywords

References

  1. The encyclopedia of Wakan-Yaku with color pictures Namba, T.
  2. Korea J. Ginseng Sci. v.20 Recent studies on the chemical constituents of Korean Ginseng (Panax ginseng C.A. Meyer) Park, J.D.
  3. Chem. Pharm. Bull. v.33 Studies on the mechanism of the hypoglycemic activity of $ginsenoside-Rb_2$ in streptozotocin-diabetic rats Yokozawa, T.;Kobayashi, T.;Oura, H.;Kawashima, Y.
  4. Chem. Pharm. Bull. v.37 Studies on the panaxytriol of Panax ginseng C. A. Meyer Isolation, determination and anti-tumor activity Matsunaga, H.;Katano, M.;Yamamoto, H.;Mori, M.;Takata, K.
  5. Arch. Pharm. Res. v.19 Maltol, an antioxidant component of Korean red ginseng, show little prooxidant activity Suh, D.Y.;Han, Y.N.;Han, B.H.
  6. Yakhak Hoeji. v.29 no.5 Radio-protective effects of ginseng proteins Kim, C.M.;Han, G.S.
  7. Agents Actions. v.15 Immunomodulatory effects of Panax ginseng C.A. Meyer in the mouse Jie, Y.H.;Cammisuli, S.;Baggiolini, M.
  8. Chem. Pharm. Bull. v.14 Chemical studies on oriental plant drugs (XIV). Protopanaxadiol, a genuine sapogenin of ginseng saponins Shibata, S.;Tanaka, T.;Ando, T.;Sado, M.;Tsushima, S.;Ohsawa, T.
  9. Mutat Res. v.523 Inhibitory effects of ginsenoside $Rg_3$ on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion Keum, Y.S.;Han, S.S.;Chun, K.S.;Park, K.K.;Park, J.H.;Lee, S.K.;Surh, Y.J.
  10. Eur. J. Pharmacol. v.367 Ginsenoside $Rg_3$ mediates endothelium-dependant relaxation in response to ginsenosides in rat aorta : role of K+ channels Kim, N.D.;Kang, S.Y.;Park, J.H.;Schini-Kerth, V.B.
  11. Cancer Lett. v.150 Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng Keum, Y.S.;Park, K.K.;Lee, J.M.;Chun, K.S.;Park, J.H.;Lee, S.K.;Kwon, H.;Surh, Y.J.
  12. J. Chromatogr. A. v.921 Liquid chromatographic determination of less polar ginsenosides in processed ginseng Kwon, S.W.;Han, S.B.;Park, I.H.;Kim, J.M.;Park, M.K.;Park, J.H.
  13. Korean J. Food Sci. Technol. v.35 Analysis of ginsenosides of white and red ginseng concentrates Ko, S.K.;Lee, C.R.;Choi, Y.E.;Im, B.O.;Sung, J.H.;Yoon, K.R.
  14. Korean J. Food Sci. Technol. v.36 Comparison of ginsenoside composition and contents in fresh ginseng roots cultivated in Korea, japan, and China at various ages Lee, C.R.;Whang, W.K.;Shin, C.G.;Lee, H.S.;Han, S.T.;Im, B.O.;Ko, S.K.