Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Effect of Dietary Docosahexaenoic Acid on Maze-learning Ability in Aged Mice Fed N-3 Fatty Acid Deficient Diet

  • Published : 2005.12.31
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Abstract

The effect of docosahexaenoic acid (DHA) on maze-learning ability in aged mice was investigated. Aged mice fed a diet deficient in n-3 fatty acid received a semi-purified diet of 0.5, 1 and 2% DHA-ethyl ester (DHA-EE) for 4 months. Maze-learning ability was assessed at 3 months after the start of the experiment. The time required to reach the maze exit and the number of times that a mouse strayed into blind alleys in the maze were measured in 3 trials conducted at 4-day intervals. The time was significantly less in the DHA-EE 0.5% and DHA-EE 2% groups than in the control group (p<0.05). The number of times mice strayed into blind alleys in the maze was significantly lower in the DHA-EE 2% group than in the control group (p<0.05). Mice fed DHA showed increased DHA and decreased level of arachidonic acid (AA) in the brain. These results suggest that the intake of a 2% DHA diet improves learning ability in aged mice, which is associated with a higher DHA content in the brain.

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References

  1. Pro. Lipid Res. v.24 Lipids of nervous system: Composition and metabolism Sastry, P.S.
  2. Nutr. Rev. v.44 N-3 Fatty acids in the brain and retina: Evidence for their essentiality Neuringer, M.;Connor, W.E.
  3. Ann. Rev. Nutr. v.8 The essentiality of n-3 fatty acids for the development and function of the retina and brain Neuringer, M.;Anderson, G.J.;Connor, W.E.
  4. Prog. Lipid Res. v.30 Essential fatty acids in growth and development Innis, S.M.
  5. Biochem. Int. v.17 Aging influence on delta-6-desaturase activity and fatty acid composition of rat liver microsomes Bordoni, A.;Biagi, P.L.;Turchetto, E.;Hrelia, S.
  6. Lipids v.28 Age-related changes in 8 6 and 8 5 desaturase activities in rat liver microsomes Maniongui, C.;Blond, J.P.;Ulmamm, L.;Durand, G.;Poisson, J.P.;Bezard, J.
  7. Prog. Lipid Res. v.23 Effect of unsaturated acids on membrane structure and enzyme kinetics Brenner, R.R.
  8. Biochim. Biophys. Acta v.779 The modification of mammalian membrane polyunsaturated fatty acid composition in related to membrane fluidity and function Stubbs, C.D.;Smith, A.D.
  9. Mech. Ageing Dev. v.50 Effect of age on the modification of brain polyunsaturated fatty acids and enzyme activities by fish oil diet in rats Suzuki, H.;Hayakawa, S.;Wada, S.
  10. J. Neurochem. v.75 Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration Moriguchi, T.;Greiner, R.S.;Salem, N.
  11. Lipids v.34 Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks Greiner, R.S.;Moriguchi, T.;Hutton, A.;Slotnick, B.M.;Salem, N.
  12. J. Lipid Res. v.45 Effects of an n-3 deficient diet on brain, retina, and liver fatty acyl composition in artificially reared rats Moriguchi, T.;Lim, S.Y.;Greiner, R.S.;Lefkowitz, W.;Loewke, J.;Hoshiba, J.;Salem, N.
  13. Artificial feeding of an n-3 essential fatty acid deficient diet leads to loss of brain function in the first generation;Essential Fatty acids and Eicosanoids Lim, S.Y.;Moriguchi, T.;Lefkowitz, W.;Loewke, J.;Majchrza, S.;Hoshiba, J.;Salem, N.;Huang, Y.S.(ed.);Lin, S.J.(ed.);Huang, P.C.(ed.)
  14. Physiol. Behav. v.72 Olfactory discrimination deficits in n-3 fatty acid-deficient rats Greiner, R.S.;Moriguchi, T.;Slotnick, B.M.;Hurron, A.;Salem, N.
  15. J. Lipid Res. v.28 Effect of dietary alpha-Iinolenate/linoleate balance on brain lipid compositions and learning ability of rats Yamamoto, N.;Saitoh, M.;Moriuchi, A.;Nomura, M.;Okuyama, H.
  16. J. Nutr. v.119 The effects of dietary alpha-linolenic acid on the composition of nerve membranes, enzymatic activity, amplitude of electrophysiological parameters, resistance to poisons and performance of learning tasks in rats Bourre, J.M.;Francois, M.;Youyou, A.;Dwnont, O.;Piciotti, M.;Pascal, G.;Durand, G.
  17. Ann. Nutr. Meta. v.40 Effect of dietary n-3 deficiency on the electroretinogram in the guinea pig Weisinger, H.S.;Vingrys, A.J.;Sinclair, A.J.
  18. The effect ofn-3 fatty acid deficiency and repletion upon the fatty acid composition and function of the brain and retina, in biological membranes: Aberrations in membrane structure and function Connor, W.E.;Neuringer, M.;Karnovsky, M.I.(ed.);Leaf, A.(ed.);Bolls, L.C.(ed.)
  19. Invest. Ophthalmol. Vis. Sci. v.33 Dietary essential fatty acid supply and visual acuity development Birch, E.E.;Birch, D.O.;Hoffinan, D.R.;Uauy, R.
  20. Lipids v.31 A randomized trial of visual attention of preterm infants fed docosahexaenoic acid until two months Carlson, S.E.;Werkman, S.H.
  21. Lancet v.352 Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age Willatts, P.;Forsyth, J.S.;Dimodugno, M.K.;Varma, S.;Colvin, M.
  22. J. Nutr. Sci. Vitaminol. v.36 Effect of a histidine-excess diet on a tetrahydrofolylpolyglutamate pattern in rat liver Kohashi, M.;Takahashi, A.;Iwai, K.
  23. J. Nutr. v.130 Intakes of docosahexaenoic acid ethylester and egg-phosphatidylcholine improve maze-learning ability in young and old mice Lim, S.Y.;Suzuki, H.
  24. Canadian J. Biochem. Phys. v.37 A rapid method of total lipid extraction and purification Bligh, E.O.;Dyer, W.J.
  25. AOCS Official Method 1b-89 Official methods and recommended practices of the American oil chemists' society
  26. Neurosci. Biobehav. v.16 Do essential fatty acids playa role in brain and behavioral development? Wainwirght, P.E.
  27. Lipids v.26 Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease Soderbberg, M.;Edlund, C.;Kristensson, K.;Dallner, G.
  28. Brain Res. v.669 Dietary alpha-linolenate/linoleate balance influences learning and memory in the senescence-accelerated mouse (SAM) Umezawa, M.;Ohta, A.;Tojo, H.;Yagi, H.;Hosokawa, M.;Takeda, T.
  29. J. Gerontol v.46 Effect of a high-linoleate and a high a-linolenate diet on the learning ability of aged rats Yamamoto, N.;Okaniwa, Y.;Mori, S.;Nomura, M.;Okuyama, H.
  30. J. Clin. Ther. Med. v.11 Clinical effects of DHA in demented patients Miyanaga, K.;Yonemura, K.;Takgi, T.;Kifune, R.;Kishi, Y.;Miyakawa, F.;Yazawa, K.;Shirota, Y.
  31. Lipids v.38 Effects of docosapentaenoic acid on neuronal apoptosis Kim, H.Y.;Akbar, M.;Lau, A.
  32. J. Biol. Chem. v.275 Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3);Role of phosphatidylserine in antiapoptotic effect Kim, H.Y.;Akbar, M.;Lau, A.;Edsall, L.
  33. J. Biol.Chem. v.279 Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency Niu, S.L.;Mitchell, D.C.;Lim, S.Y.;Wen, Z.M.;Kim, H.Y.;Salem, N.;Litman, B.J.
  34. Phannacol. Biochem. Behav. v.58 Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats Minami, M.;Kimura, S.;Endo, T.;Hamaue, N.;Hirahuji, M.;Togashi, H.;Matswnoto, M.;Yoshioka, M.;Saito, H.;Watanabe, S.;Kobayashi, T.;Okuyama, H.
  35. J. Lipid Res. v.41 Modification of dopamine neurotransmission in the nucleus accwnbens of rats deficient in n-3 polyunsaturated fatty acids Zimmer, L.;Delion-Vancassel, S.;Durand, G.;Guilloteau, D.;Bodard, S.;Jean-Claude, B.;Chalon, S.
  36. Physiol. Behav. v.55 Home cage behavior of rhesus monkeys with long-term deficiency of omega-3-fatty acids Gamoh, S.;Hashimoto, M.;Hasnain, R.;Connor, W.E.
  37. Int. J. Vitam. Nutr. Res. v.72 Dose-response effect of docosahexaenoic acid ethylester on maze behavior and brain fatty acid composition in adult mice Lim, S.Y.;Suzuki, H.