Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
권호 표지

Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma

Ha, Tae-Won;Han, Ki-Hwan;Son, Dae-Gu;Kim, Sang-Pyo;Kim, Dae-Kwang

  • Published : 20050400

⟨ Previous Next ⟩

Abstract

Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and malignant melanoma as well as other types of skin cancer. A few studies on LOH in sporadic keratoacanthomas have been reported. The Purpose of this study was to investigate the significance of LOH in the pathogenesis of sporadic keratoacanthomas developed in 10 Korean patients. The presents of LOH at 7 microsatellite markers (D2S286, D3S1317, D5S346, D9S160M D9S171, D10S185, and D17S261) were evaluated in sporadic keratoacanthomas. LOH was found in only 1 of 10 cases at D10S185. The low frequency of LOH detected in this study suggests that LOH may not be significant in the induction of sporadic keratoacanthomas.

Keywords

References

  1. J Cutan Pathol v.7 The histopathologic differentiation of keratoacanthoma and squamous cell carcinoma of the skin Kern, W.H.;McCray, M.K. https://doi.org/10.1111/j.1600-0560.1980.tb01202.x
  2. J Am Acad Dermatol v.30 Keratoacanthoma Schwartz, R.A.
  3. Ann Plast Surg v.9 Are kearatoacanthomas really squamous cell carcinomas? Sanders, G.H.;Miller, T.A. https://doi.org/10.1097/00000637-198210000-00006
  4. J Dermatol Surg Oncol v.16 Aggressive keratoacanthoma of the eyelid: 'malignant' keratoacanthoma or squamous cell carcinoma? Requena, L.;Romero, E.;Sanchez, M.;Ambrojo, P.;Sanchez Yus, E.
  5. Am J Dermatopathol v.15 Solitary keratoacanthoma is a squamous cell carcinoma: three examples with metastases Hodak, E.;Jones, R.E.;Ackerman, A.B.
  6. Science v.278 Human cancer syndromes: clues to the origin nature of cancer Fearon, E.R. https://doi.org/10.1126/science.278.5340.1043
  7. Cancer Res v.56 Frequent abnormalities of FHIT, a candidate tumor suppressor gene, in head and neck cancer cell lines Mao, L.I.;Fan, Y.H.;Lotan, R.;Hong, W.K.
  8. Cell v.61 A genetic model for colorectal tumorigenesis Fearon, E.R.;Vogelstein, B. https://doi.org/10.1016/0092-8674(90)90186-I
  9. Cancer Res v.56 Genetic progression model for head and neck cancer: implications for field cancerization Califano, J.;van der Riet, P.;Westra, W.;Nawroz, H.;Clayman, G.;Piantadosi, S.;Corio, R.;Lee, D.;Greenberg, B.;Koch, W.;Sidransky, D.
  10. Arch Dermatol Res v.289 Analysis of microsatellite instability and loss of heterozygosity in keratoacanthoma Peris, K.;Magrini, F.;Keller, G.;Manente, L.;D’Alessandro, E.;Onorati, M.T.;Hofler, H.;Chimenti, S. https://doi.org/10.1007/s004030050178
  11. Arch Dermatol Res v.291 Assessment of microsatellite instability and loss of heterozygosity in sporadic keratoacanthomas Langenbach, N.;Kroiss, M.M.;Ruschoff, J.;Schlegel, J.;Landthaler, M.;Stolz, W. https://doi.org/10.1007/s004030050376
  12. Br J Cancer v.73 Loss of heterozygosity analysis of keratoacanthoma reveals multiple differences from cutaneous squamous cell carcinoma Waring, A.J.;Takata, M.;Rehman, I.;Rees, J.L.
  13. Cancer Genet Cytogenet v.142 A specific chromosome aberration in a keratoacanthoma Kim, D.K.;Kim, J.Y.;Kim, H.T.;Han, K.H.;Shon, D.G. https://doi.org/10.1016/S0165-4608(02)00734-3
  14. Genet Anal v.15 A reliable PCR amplification method for microdissected tumor cells obtained from paraffin-embedded tissue Akalu, A.;Reichardt, J.K.
  15. J Med Genet v.33 Loss of heterozygosity in tuberous sclerosis hamartomas Sepp, T.;Yates, J.R.;Green, A.J.
  16. Arch Dermatol v.136 Sporadic trichoepithelioma demonstrates deletions at 9q22.3 Matt, D.;Xin, H.;Vortmeyer, A.O.;Zhuang, Z.;Burg, G.;Boni, R. https://doi.org/10.1001/archderm.136.5.657
  17. J Med Genet v.35 Familial cylindromatosis mimicking tuberous sclerosis complex and confirmation of the cylindromatosis locus, CYLD1, in a large family Verhoef, S.;Schrander-Stumpel, C.T.;Vuzevski, V.D.;Tempelaars, A.;Jansen, L.A.;Malfeyt, G.A.;Ceelen, T.L.;Lindhout, D.;Halley, D.J.;van den Ouweland, A.M.
  18. Arch Dermatol v.134 Loss of heterozygosity detected on 1p and 9q in microdissected atypical nevi Boni, R.;Zhuang, Z.;Albuquerque, A.;Vortmeyer, A.;Duray, P. https://doi.org/10.1001/archderm.134.7.882
  19. J Invest Dermatol v.110 Cutaneous tumors in patients with multiple endocrine neoplasia type 1 show allelic deletion of the MEN1 gene Pack, S.;Turner, M.L.;Zhuang, Z.;Vortmeyer, A.O.;Boni, R.;Skarulis, M.;Marx, S.J.;Darling, T.N. https://doi.org/10.1046/j.1523-1747.1998.00140.x
  20. Nat Genet v.11 Benign neurofibromas in type1 neurofibromatosis (NF1) show somatic deletions of the NF1 gene Colman, S.D.;Williams, C.A.;Wallace, M.R. https://doi.org/10.1038/ng0995-90
  21. Cancer Genet Cytogenet v.39 Clonal chromosome aberrations in a keratoacanthoma and a basal cell papilloma Mertens, F.;Heim, S.;Mandahl, N.;Johansson, B.;Rydholm, A.;Biorklund, A.;Wennerberg, J.;Jonsson, N.;Mitelman, F. https://doi.org/10.1016/0165-4608(89)90189-1
  22. J Am Acad Dermatol v.33 The Muir-Torre syndrome: a 25-year retrospect Schwartz, R.A.;Torre, D.P. https://doi.org/10.1016/0190-9622(95)90017-9
  23. Lancet v.344 High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease Rehman, I.;Quinn, A.G.;Healy, E.;Rees, J.L. https://doi.org/10.1016/S0140-6736(94)92343-4
  24. Am J Dermatopathol v.17 Quantitative image analysis of p53 protein accumulation in keratoacanthomas Borkowski, A.;Bennett, W.P.;Jones, R.T.;Borkowski, P.;Harris, C.C.;Ferreira, L.R.;Kao, G.F.;Trump, B.F.
  25. Arch Dermatol v.133 P53 oncoprotein expression and gene mutations in some keratoacanthomas Perez, M.I.;Robins, P.;Biria, S.;Roco, J.;Siegel, E.;Pellicer, A. https://doi.org/10.1001/archderm.133.2.189
  26. J Invest Dermatol v.119 Keratoacanthomas frequently show chromosomal aberrations as assessed by comparative genomic hybridization Clausen, O.P.;Beigi, M.;Bolund, L.;Kolvraa, S.;Gjersvik, P.J.;Mork, G.;de Angelis, P.M. https://doi.org/10.1046/j.1523-1747.2002.19613.x