Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
권호 표지

Lung Cancer Screening with Low-Dose Helical CT in Korea: Experiences at the Samsung Medical Center

Chong, Se-Min;Lee, Kyung-Soo;Chung, Myung-Jin;Kim, Tae-Sung;Kim, Ho-Joong;Kwon, O-Jung;Choi, Yoon-Ho;Rhee, Chong-H.

  • Published : 20050600

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Abstract

To determine overall detection rates of lung cancer by low-dose CT (LDCT) screening and to compare histopathologic and imaging differences of detected cancers between high- and low-risk groups, this study included 6,406 asymptomatic Korean adults with ${\geq}45$ yr of age who underwent LDCT for lung cancer screening. All were classified into high- (${\geq}20$ pack-year smoking; 3,353) and low-risk (3,053; <20 pack-yr smoking and non-smokers) groups. We compared CT findings of detected cancers and detection rates between high- and low-risk. At initial CT, 35% (2,255 of 6,406) had at least one or more non-calcified nodule. Lung cancer detection rates were 0.36% (23 of 6,406). Twenty-one non-small cell lung cancers appeared as solid (n=14) or ground-glass opacity (GGO) (n=7) nodules. Cancer likelihood was higher in GGO nodules than in solid nodules (p<0.01). Fifteen of 23 cancers occurred in high-risk group and 8 in low-risk group (p=0.215). Therefore, LDCT screening help detect early stage of lung cancer in asymptomatic Korean population with detection rate of 0.36% on a population basis and may be useful for discovering early lung cancer in low-risk group as well as in high-risk group.

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