Journal of Korean Medical Science

Korean Acad Medical Sciences (대한의학회)
권호 표지

The Effect of Apolipoprotein E Polymorphism on Lipid Levels in Korean Adults

Shin, Min-Ho;Kim, Hee-Nam;Cui, Lian-Hua;Kweon, Sun-Seog;Park, Kyeong-Soo;Heo, Heon;Nam, Hae-Sung;Jeong, Seul-Ki;Chung, Eun-Kyung;Choi, Jin-Su

  • Published : 20050600

⟨ Previous Next ⟩

Abstract

The aim of this study was to determine the effects of polymorphisms in the apolipoprotein E gene (APOE) on lipid levels in Korean adults and to investigate the interactions between these polymorphisms and environmental factors in determining lipid levels. We performed a cross-sectional study of 1,900 subjects (668 men and 1,232 women; 45-74 yr old) in Namwon, Korea, in 2004. APOE polymorphisms were determined by polymerase chain reaction and restriction enzyme analysis. Carriers of the APOE*E2 (E2) allele had significantly lower total cholesterol and lowdensity lipoprotein cholesterol (LDL-C) concentrations than did carriers of the APOE*E3 (E3) or APOE*E4 (E4) alleles, regardless of gender. The APOE allele type had significant effect on high-density lipoprotein cholesterol (HDL-C) and triglyceride levels in women, but not in men. The effect of APOE allele type on HDL-C levels was modified by age in women. In addition, in men, the effect of APOE allele type on triglyceride levels was modified by smoking. These findings highlight the important effect of gene-environment interactions on lipid levels.

Keywords

References

  1. Science v.240 Apolipoprotein, E.: cholesterol transport protein with expanding role in cell biology Mahley, R.W. https://doi.org/10.1126/science.3283935
  2. Nature v.269 Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man Utermann, G.;Hees, M.;Steinmetz, A. https://doi.org/10.1038/269604a0
  3. Arteriosclerosis v.8 Apolipoprotein E polymorphism and atherosclerosis Davignon, J.;Gregg, R.E.;Sing, C.F.
  4. Metabolism v.50 Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: ecogenetic studies in a Mediterranean Spanish population Corella, D.;Guillen, M.;Saiz, C.;Portoles, O.;Sabater, A.;Cortina, S.; Folch, J.;Gonzalez, J.I.;Ordovas, J.M. https://doi.org/10.1053/meta.2001.24867
  5. Atherosclerosis v.170 APOE polymorphism and lipid profile in three ethnic groups in the Singapore population Tan, C.E.;Tai, E.S.;Tan, C.S.;Chia, K.S. Lee, J.;Chew, S.K.;Ordovas, J.M. https://doi.org/10.1016/S0021-9150(03)00232-6
  6. Eur J Clin Invest v.28 Lack of influence of apolipoprotein E4 on lipoprotein levels in the island population of Sardinia Deiana, L.;Pes, G.M.;Carru, C.;Errigo, A.;Pettinato, S.;Carcassi, C.; Baggio, G.;Contu, L. https://doi.org/10.1046/j.1365-2362.1998.00271.x
  7. Atherosclerosis v.142 The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a native American population following its traditional lifestyle Aguilar, C.A.;Talavera, G.;Ordovas, J.M.;Barriguete, J.A.;Guillen, L.E.;Leco, M.E.;Pedro-Botet, J.;Gonzalez-Barranco, J.;Gomez-Perez, F.J.;Rull, J.A. https://doi.org/10.1016/S0021-9150(98)00251-2
  8. J Lipid Res v.41 Context-dependent and invariant associations between lipids, lipoproteins, and apolipoproteins and apolipoprotein E genotype Frikke-Schmidt, R.;Nordestgaard, B.G.;Agerholm-Larsen, B.;Schnohr, P.;Tybjaerg-Hansen, A.
  9. Arterioscler Thromb Vase Biol v.22 Impact of alcohol intake on measures of lipid metabolism depends on context defined by gender, body mass index, cigarette smoking, and apolipoprotein E genotype Lussier-Cacan, S.;Bolduc, A.;Xhignesse, M.;Niyonsenga, T.;Sing, C.F. https://doi.org/10.1161/01.ATV.0000014589.22121.6C
  10. Atherosclerosis v.118 Gene-diet interaction in determining plasma lipid response to dietary intenvention Ordovas, J.M.;Lopez-Miranda, J.;Mata, P.;Perez-Jimenez, F.; Lichtenstein, A.H.;Schaefer, E.J.
  11. Clin Biochem v.37 Validation of the Friedewald formula for the determination of low-density lipoprotein cholesterol compared with beta-quantification in a large population Tremblay, A.J.;Morrissette, H.;Gagne, J.M.;Bergeron, J.;Gagne, C.; Couture, P. https://doi.org/10.1016/j.clinbiochem.2004.03.008
  12. Clin Chem v.18 Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Friedewald, W.T.;Levy, R.I.;Fredrickson, D.S.
  13. J Lipid Res v.31 Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI Hixson, J.E.;Vernier, D.T.
  14. Ann Clin Biochem v.38 Apolipoprotein E polymorphism and serum lipoprotein (a) concentrations in a Korean male population Chun, S.;Min, W.K.;Kim, J.W.;Park, H.;Jang, S.;Yang, S.E.;Kim, J.Q. https://doi.org/10.1258/0004563011900434
  15. J Gerontol A Biol Sci Med Sci v.58 Distributions of ACE and APOE polymorphisms and their relations with dementia status in Korean centenarians Choi, Y.H.;Kim, J.H.;Kim, D.K.;Kim, J.W.;Lee, M.S.;Kim, C.H.;Park, S.C.
  16. J Lipid Res v.27 Apolipoprotein E polymorphism in the Finnish population: gene frequencies and relation to lipoprotein concentrations Ehnholm, C.;Lukka, M.;Kuusi, T.;Nikkila, E.;Utermann, G.
  17. J Lipid Res v.33 Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis Dallongeville, J.;Lussier-Cacan, S.;Davignon, J.
  18. Atherosclerosis v.147 Apolipoprotein E polymorphism in men and women from a Spanish population: allele frequencies and influence on plasma lipids and apolipoproteins Gomez-Coronado, D.;Alvarez, J.J.;Entrala, A.;Olmos J.M.;Herrera, E.; Lasuncion, M.A. https://doi.org/10.1016/S0021-9150(99)00168-9
  19. Eur J Clin Invest v.15 Plasma apolipoprotein B metabolism in familial type III dysbetalipoproteinaemia Turner, P.R.;Cortese, C.;Wootton, R.;Marenah, C.;Miller, N.E.;Lewis B.
  20. J Clin Invest v.88 Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects Demant, T.;Bedford, D.;Packard, C.J.;Shepherd, J.
  21. Atherosclerosis v.121 Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp (a) in a Spanish population underexpressing apoE4 Muros, M.;Rodriguez-Ferrer, C. https://doi.org/10.1016/0021-9150(95)06643-8
  22. Metabolism v.51 Effects of apolipoprotein E genotype on dietary-induced changes in high-density lipoprotein cholesterol in obese postmenopausal women Nicklas, B.J.;Ferrell, R.E.;Bunyard, L.B.;Berman, D.M.;Dennis, K.E.; Goldberg, A.P. https://doi.org/10.1053/meta.2002.33337
  23. Metabolism v.51 The effect of age, body mass index, and fasting triglyceride level on postprandial lipemia is dependent on apolipoprotein E polymorphism in subjects with non-insulin-dependent diabetes mellitus Reznik, Y.;Morello, R.;Pousse, P.;Mahoudeau, J.;Fradin, S. https://doi.org/10.1053/meta.2002.34696
  24. Arterioscler Thromb v.14 Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham offspring Study Schaefer, E.J.;Lamon-Fava, S.;Johnson, S.;Ordovas, J.M.;Schaefer, M.M.;Castelli, W.P.;Wilson, P.W.
  25. Curr Opin Lipidol v.13 Gene: environment interaction in lipid metabolism and effect on coronary heart disease risk Talmud, P.J.;Humphries, S.E. https://doi.org/10.1097/00041433-200204000-00006