The Effect of an AP-l decoy on Collagen Synthesis in Wound Healing on Rat Skin : The use of Gene Therapy to Minimise Scarring

흰쥐 피부창상에서 AP-1 decoy에 의한 교원질 생성효과: 반흔의 유전자 치료 가능성

Park, Soo-Jung;Lee, Kyu-Suk
박수정;이규석

  • Published : 20050400

Abstract

Keywords

References

  1. Murray JC, Pollack SV, Pinnel SR. Keloid: A review. J Am Acad Dermatol 1981:4:461-470 https://doi.org/10.1016/S0190-9622(81)70048-3
  2. Whang KK, Park HJ, Myung KB. The Clinical Analysis of the Combination of Cryosurgery and Intralesional Corticosteroid on Hypertrophic Scars. Kor J Dermatol 1997;35:450-457
  3. Albert JN. Keloids and hypertrophic scars. J Dermatol Surg Oncol 1993;19:738-746
  4. Muir IFK. On the nature of keloid and hypertrophic scar. Br J Plast Surg 1990;43:61-69 https://doi.org/10.1016/0007-1226(90)90046-3
  5. Datubu-Brown DD. Keloids: a review of the literature. Br J Plast Surg 1990;43:70-77 https://doi.org/10.1016/0007-1226(90)90047-4
  6. Singer AJ, Clark RAF Cutaneous wound healing. N Engl J Med 1999;341:738-746 https://doi.org/10.1056/NEJM199909023411006
  7. Hatamochi A, Mori K, Ueki H. Role of cytokines in controlling connective tissue gene expression. Arch Dermatol Res 1994;287;115-121 https://doi.org/10.1007/BF00370729
  8. Tredget EE, Nedelec B, Scott PG, Ghahary A. Hypertrophic scars, keloids, and contractures. Dermatol clin 1993; 11:701-730
  9. Kim SY, Lee HG, Lee JC. A Study on the Proliferation and the Collagen Synthesis of the Fibroblasts Cultured from Normal Skin and Hypertrophic Scar. Kor J Dermatol 2002;40:751-758
  10. Shah M, Foreman DM, Ferguson MW. Control of scarring in adult wounds by neutralizing antibody to transforming growth factor B. Lancet 1992;339:213-214 https://doi.org/10.1016/0140-6736(92)90009-R
  11. Polo M, Smith PD, Kim YJ, Wang X, Ko F, Robson MC. Effect of TGF-$\beta$ on proliferative scar fibroblast cell kinetics. Ann Plast Surg 1999;43:185-190 https://doi.org/10.1097/00000637-199943020-00014
  12. Teofoli P, Bardaugni S, Ribuffo M, Campanella A, De pita' O, Puddu P. Expression of Bcl-2, p53, c-jun and c-Fos protooncogenes in keloids and hypertrophic scars. J Dermatol Sci 1999;22:31-37 https://doi.org/10.1016/S0923-1811(99)00040-7
  13. Chung KY, Agarwal A, Uitto J, Mauviel. An AP-1 binding sequence is essential for regulation of the human a 2(I) collagen (COLlA2) promoter activity by transforming growth factor-$\beta$. J Biol Chem 1996;271:3272-3278 https://doi.org/10.1074/jbc.271.6.3272
  14. Ahn JD, Morishita R, Kaneda Y, Lee SJ, Kwon KY, Choi SY et al. Inhibitory effects of novel AP-1 decoy oligodeoxynucleotides on vascular smooth muscle cell proliferation in vitro and neointimal formation in vivo. Circ Res 2002;90: 1325-1332 https://doi.org/10.1161/01.RES.0000023200.19316.D5
  15. Ahn JD, Morishita R, Kaneda Y, Lee KU, Park JY, Jeon YJ et al. Transcription factor decoy for activator protein-l (AP-l) inhibits high glucose and angiotensin II-induced typel plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth muscle cells. Diabetologia 2001;44:713-720 https://doi.org/10.1007/s001250051680
  16. Morishita R, Sugimoto T, Aoki M, Kida I, Tomita N, Moriguchi A et al. In vivo transfection of cis element 'decoy' against NF-[kappa]B binding site prevented myocardial infarction as gene therapy. Nat Med 1997;3:894-899 https://doi.org/10.1038/nm0897-894
  17. Morishita R, Gibbons GH, Horiuchi M, Kaneda Y, Ogihara T, Dzau VJ. Role of AP-1 complex in angio-gensis II-mediated transforming growth factor-$\beta$ expression and growth of smooth muscle cells: using decoy approach against AP-1 binding site. Biochem Biophys Res Commun 1998;243:361-367 https://doi.org/10.1006/bbrc.1997.8012
  18. Ghosh AK. Factors involved in the regulation of type I collagen gene expression; implication in fibrosis. Exp Biol Med 2002;227:301-314
  19. Kerr LD, Miller DB, Matrisian LM. TGF-$\beta$1 inhibition of Transin/ Stromelysin gene expression in mediated throgh a fos binding sequence. Cell 1990;61:267-278 https://doi.org/10.1016/0092-8674(90)90807-Q
  20. Quinones S, Buttice G, Kurkinen M. Promotor elements in the transcriptional activation of the human stromelysin- 1 gene by the inflammatory cytokine, interleukin 1. Biochem J 1994;302:471-477
  21. Kim CW, Suh SI, Lee IK, Lee KS. A transcriptional factor decoy against AP-1 suppresses TGF-$\beta$1-induced typeI collagen gene expression in cultured keloid fibro-blasts. J Dermatol Sci 2005;37:49-51 https://doi.org/10.1016/j.jdermsci.2004.09.008