Korean Journal of Family Medicine (가정의학회지)

The Korean Academy of Family Medicine (대한가정의학회)
권호 표지

The Effect of Physical Activity on Colorectal Polyps

신체활동이 한국성인의 대장용종 발생에 미치는 영향

Kim, Moon-Chan;Kim, Chang-Sup;Jeong, Tae-Heum
김문찬;김창섭;정태흠

  • Published : 20050700
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Abstract

Background: The results of previous epidemiologic studies showed that dietary and life style factors are associated with colon polyps. Despite the high prevalence of colon polyps, little is known about its risk factors in Korean adults. The aim of this study was to assess the relationship between physical activity and the presence of colorectal polyps. Methods: In 859 subjects, rectosigmoidoscopy was performed at Ulsan University Hospital Health Promotion Center from January 2002 to October 2002. Drinking, smoking and other confounding factors were assessed by self-administered questionnaire in 161 subjects with colon polyps and 698 controls. Results: Among the total of 859 cases the prevalence of colorectal adenomatous polyps was 18.7%. After adjusting for age, sex, physical activity, obesity, calcium and total energy intake,using multiple logistic regression, decreasing risk of colorectal polyps were observed with increasing level of physical activities. The odds ratio for 3 to 4 hours per week exercise group was 0.460 (CI=0.262$\sim$0.089). The frequency and intensity of exercise also had an inverse association with colon polyps (4$\sim$5 times/week group: OR=0.428, CI=0.220$\sim$0.832. vigorous exercise group: OR=0.454, CI=0.298$\sim$0.693). Conclusion: Physical activities were inversely associated with colorectal polyps in Korean adults.

연구배경: 대장용종은 대장암의 전구병소이며 대장용종의 위험요인으로는 음주, 흡연, 비만, 식생활 습관 등이 있다. 신체활동의 대장암 예방효과에 대한 연구는 상반되는 결과가 혼재하고 있다. 이에 저자는 나이, 성별, 비만, 음주, 흡연, 식이요인 등 대장용종의 발생에 영향을 미치는 것으로 알려진 여러 변수를 동시에 조사하여 이들의 영향을 보정한 상태에서 신체활동이 대장용종의 발생에 미치는 영향을 규명하고자 하였다. 방법: 울산대학교병원 건강증진센터에서 2002년 1월부터 10월까지 무증상 환자를 대상으로 S상 결장경 검사를 시행 한 검진자 중에서 과거 대장용종으로 진단받은 적이 있거나, 치료를 받은 경우 그리고 암 및 비특이성 용종으로 진단된 경우를 제외한 859명의 검진자를 대상으로 하였다. 여러 요인들이 대장용종의 발생에 미치는 영향을 평가하기 위해 다중 로지스틱 회귀분석(multiple logistic regression)을 이용하여 연령, 성별, 음주, 흡연, 식이영양 등의 교란변수를 통제한 상태에서 교차비(odds ratio)와 95% 신뢰구간을 추정하였다. 결과: 총 859명의 대상자 중 남자 588 (68.5%)명, 여자 271 (31.5%)명이었으며 평균 연령은 남자 48.00$\pm$9.35, 여자 49.94$\pm$9.66이었다. 신체활동과 대장용종 발생과의 관련성을 살펴보면 연령, 나이, 하루섭취열량, 하루섭취 칼슘양, 비만, 음주, 흡연의 영향을 보정하고 주당 4시간 이상 운동을 하는 군에서의 교차비가 0.216 (95% 신뢰구간: 0.087$\sim$0.535)로 주당 운동시간이 증가할수록 대장용종 발생의 위험은 감소되는 것으로 나타났으며, 주당 운동횟수가 6회 이상인 군에서의 교차비 0.180 (95% 신뢰구간: 0.068$\sim$0.475), 자가인식 운동강도가 5 이상인 군에서의 교차비 0.094 (95% 신뢰구간: 0.027$\sim$0.326)로 주당운동횟수 및 운동강도 역시 운동횟수와 강도가 증가할수록 대장용종 발생의 위험은 감소하는 경향을 보였다. 결론: 연구결과 신체활동은 대장용종의 발생위험을 감소시켰으며 건강증진 및 암의 예방을 위해서도 신체활동은 강조되어야 할 것이다.

Keywords

References

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