Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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Functional MRI Assessment of Hemispheric Language Dominance with Using a Lexical Decision Task

기능적 자기공명영상에서 어휘판단과제를 이용한 언어 우세반구의 결정

Ryoo, Jae-Wook;Choi, Dae-Seob;Na, Dong-Gyu;Cho, Jae-Min;Kim, Sam-Soo;Park, Eui-Dong;You, Jin-Jong;Cha, Sang-Hoon
유재욱;최대섭;나동규;조재민;김삼수;박의동;유진종;차상훈

  • Published : 2005.05.30
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Abstract

Purpose: We wanted to compare the fMRIs (functional magnetic resonance images) obtained during a lexical decision task and also during a word generation task, and we wanted to evaluate the usefulness of using a lexical decision task for the visualization of the brain language area and for the determination of language dominance. Materials and Methods: Sixteen patients (9 women and 7 men) who had had undergone the Wada test were included in our study. All the patients were left dominant for language, as tested for on the Wada test. The functional maps of the brain language area were obtained in all the subjects during the performance of a lexical decision task and also during the performance of a word generation task. The MR examinations were performed with a 1.5 T scanner and with using the EPI BOLD technique. We used the SPM program for the postprocessing of the images. The threshold for significance was set at p<0.001 or p<0.01. A lateralization index was calculated from the number of activated pixels in each hemispheric region (the whole hemisphere, the frontal lobe and the temporoparietal lobe), and the hemispheric language dominance was assessed by the lateralization index; the results were then compared with those results of the Wada tests. The differences for the lateralization of the language area were analyzed with regard to the stimulation tasks and the regions used for the calculation of the lateralization indices. Results: The number of activated pixels during the lexical decision task was significantly smaller than that of the word generation task. The language dominance based on the activated signals in each hemisphere, was consistent with the results of the Wada test for the word generation tasks in all the subjects. On the lexical decision task, the language dominance, as determined by the activated signals in each hemisphere and the temporoparietal lobe, correlated for 94% of the patients. The mean values of the lateralization index for the lexical decision task were higher than those mean values of the lateralization index of the word generation task. Conclusion: The lexical decision task allowed us to map the language area and to determine the language dominance. It could be a useful task for those patients who cannot perform the word generation task because of their cognitive retardation.

목적: 어휘판단과제를 이용한 기능적 자기공명영상을 단어생성과제를 이용한 영상과 비교하여 언어기능의 영상화 및 우세반구의 판정에 있어 어휘판단과제의 유용성을 알아보고자 하였다. 대상과 방법: Wada 검사를 시행한 환자 16명을 대상(여자 9명, 남자 7명)으로 하였고, Wada 검사 결과 언어기능의 우세반구는 모두 좌측이었다. 어휘판단과제와 단어생성과제를 이용하여 언어기능의 활성화를 유도하였다. 1.5 T MR기기에서 EPI BOLD 기법을 이용하여 기능적 영상을 얻었다. 영상후처리는 SPM 분석 프로그램을 사용하였으며 활성화 신호의 유의수준은 p<0.001 또는 p<0.01을 기준으로 하였다. 활성화 영상에서 나타난 활성화 신호를 반구전체, 전두엽, 측두정엽으로 나누어 측정하여 편재화지수를 구하였고 이를 기준으로 우세반구를 결정하여 Wada 검사와 비교하였다. 각 측정부위에서 자극 과제별로, 각 자극 과제에서 측정부위별로 편재화에 차이가 있는지를 비교하였다. 결과: 어휘판단과제를 이용한 활성화 영상에서 나타난 활성화 화소의 수는 단어생성과제에 비해 적었다. 단어생성과제의 경우 측정부위와 관계없이 기능적 자기공명영상의 편재화지수를 기준으로 우세반구를 결정하였을 때 모든 환자에서 Wada 검사의 결과와 일치하였다. 어휘판단과제의 경우 반구전체와 측두정엽의 활성화를 비교하였을 때 94%에서 Wada 검사와 일치된 결과를 얻었다. 편재화지수의 평균값은 어휘판단과제를 이용한 경우가 단어생성과제를 이용한 경우에 비해 높았다. 결론: 어휘판단과제를 이용하여 언어기능의 뇌지도를 얻을 수 있었으며 언어의 우세반구를 판정할 수 있었다. 어휘판단과제는 인지기능의 저하가 있어 단어생성과제를 수행하지 못하는 환자에서 유용한 자극과제가 될 것으로 생각된다.

Keywords

References

  1. McCarthy G, Blamire AM, Rothman DL, Gruetter R, Shulman RG. Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans. Proc Natl Acad Sci 1993;90:4952-4956
  2. Binder JR, Rao SM, Hammeke TA, Frost JA, Bandettini PA, Jesmanowicz A, et al. Lateralized human brain language systems demonstrated by task subtraction functional magnetic resonance imaging. Arch NeuroI 1995;52:593-601 https://doi.org/10.1001/archneur.1995.00540300067015
  3. Cuenod CA, Bookheimer SY, Hertz-Pannier L, Zeffiro TA, Theodore WH, Bihan DL. Functional MRI during word generation, using conventional equipment: a potential tool for language localization in the clinical environment. Neurology 1995;45:1821-1827 https://doi.org/10.1212/WNL.45.10.1821
  4. Binder JR. Functional magnetic resonance imaging: language mapping. Neurosurgery Clin North Am 1997;8:383-392
  5. Binder JR, Frost JA, Hammeke TA, Cox RW, Rao SM, Prieto T. Human brain language areas identified by functional magnetic resonance imaging. J Neurosci 1997;17:353-362
  6. 정희영, 김재형, 신태민, 박상호, 김재수, 이경우, 등. 1.5T 자기공명 영상을 이용한 사람 뇌의 언어관련기능의 Mapping: 운동성 언어기능을 중심으로. 대한방사선의학회지 1998;38:205-210
  7. 유인규, 장기현, 송인찬, 김홍대, 성수옥, 이상건, 등. EPI 기법을 이용한 운동성 뇌언어중추의 기능적 자기공명영상. 대한방사선의학회지 1998;38:957-964
  8. 유재욱, 나동규, 변홍식, 노덕우, 조재민, 문찬홍, 등. 언어영역의 기능적 자기공명영상. 대한자기공명의과학회지 1999;3:53-59
  9. Springer JA, Binder JR, Hammeke TA, Swanson SJ, Frost JA, Bellgowan PS, et al. Language dominance in nerurologically normal and epilepsy subjects: a IunctionalMkl study. Brain 1999;122:2033-2045 https://doi.org/10.1093/brain/122.11.2033
  10. Yetkin FZ, Hammeke TA, Swanson SJ, Morris GL, Mueller WM, McAuliffe TL, et al. A comparison of functional MR activation patterns during silent and audible language tasks. AJNR Am J NeuroradioI 1995;16:1087-1092
  11. Desmond JE, Sum JM, Wagner AD, Demb JB, Shear PK, Glover GH, et al. Functional MRI measurement of language lateralization in Wada-tested patients. Brain 1995;118:1411-1419 https://doi.org/10.1093/brain/118.6.1411
  12. Binder JR, Swanson SJ, Hammeke TA, Morris GL, Mueller WM, Fischer M, et al. Determination of language dominance using functional MRI: a comparison with the Wada test. Neurology 1996;46:978-984 https://doi.org/10.1212/WNL.46.4.978
  13. Bahn MM, Lin W, Silbergeld DL, Miller JW, Kuppusamy K, Cook RJ, et al. Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation. AJR Am J RoentgenoI 1997;169:575-579 https://doi.org/10.2214/ajr.169.2.9242780
  14. Worthington C, Vincent DJ, Bryant AE, Roberts DR, Vera CL, Ross DA, et al. Comparison of functional magnetic resonance imaging for language localization and intracarotid speech amytal testing in presurgical evaluation for intractable epilepsy: preliminary results. Stereotact Funct Neurosurg 1997;69:197-201 https://doi.org/10.1159/000099874
  15. Hertz-Pannier L, Gaillard WD, Mott SH, Cuenod CA, Bookheimer SY, Weinstein S, et al. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 1997;48:1003-1012 https://doi.org/10.1212/WNL.48.4.1003
  16. van der Kallen BFW, Morris GL, Yetkin FZ, van Erning LJTO, Thijssen HOM, Haughton VM. Hemispheric language dominance studied with functional MR: preliminary study in healthy volunteers and patients with epilepsy. AJNR Am J NeuroradioI 1998;19:73-77
  17. 유재욱, 나동규, 변홍식, 문찬홍, 신성욱, 김영한, 등. 기능적 자기공명영상을 이용한 언어기능의 편재화: Wada검사와의 비교에 관한 예비연구. 대한방사선의학회지 1999;40:821-827
  18. Benson RR, FitzGerald DB, LeSueur LL, Kennedy DN, Kwong KK, Buchbinder BR, et al. Language dominance determined by whole brain functional MRI in patients with brain lesions. Neurology 1999;52:798-809 https://doi.org/10.1212/WNL.52.4.798
  19. Lehericy S, Cohen L, Bazin B, Samson S, Giacomin E, Rougetet R, et al. Functional MR evaluation of temporal and frontal language dominance compared with the Wada test. Neurology 2000;54:1625-1633 https://doi.org/10.1212/WNL.54.8.1625
  20. Oldfield RC. The assessment and analysis of handedness: the Edinburgh Inventory. Neuropsychologia 1971;9:97-113 https://doi.org/10.1016/0028-3932(71)90067-4
  21. Woods RP, Cherry SR, Mazziota JC. A rapid automated algorithm for accurately aligning and reslicing PET images. J Comput Assist Tomogr 1992;16:620-633
  22. Wada J, Rasmussen T. Intracarotid injection of sodium amytal for the lateralization of cerebral speech dominance: experimental and clinical observations. J Neurosurg 1960;17:266-282 https://doi.org/10.3171/jns.1960.17.2.0266
  23. Benbadis SR, Binder JR, Swanson SJ, Fischer M, Hamrneke TA, Morris GL, et al. Is speech arrest during Wada testing a valid method for determining hemishperic representation of language? Brain Lang 1998;65:441-446 https://doi.org/10.1006/brln.1998.2018
  24. Dion JE, Gates PC, Fox AJ, Barnet HJ, Blom RJ. Clinical events following neuroangiography: a prospective study. Stroke 1987;18:997-1004 https://doi.org/10.1161/01.STR.18.6.997
  25. Hietala SO, Silfvenius H, Assly J, Olivecrona M, Jonsson L. Brain perfusion with intracarotid injection of 99mTc-HM-PAO in partial epilepsy during amobarbital testing. Eur J Nucl Med 1990;16:683-687 https://doi.org/10.1007/BF00998169
  26. Malmgren K, Bilting M, Hagberg I, Hedstrom A, Silfvenius H, Starmark JE. A compound score for estimating the influence of inattention and somnolence during the intracarotid amobarbital test. Epilepsy Res 1992;12:253-259 https://doi.org/10.1016/0920-1211(92)90079-9
  27. Bouwer MS, Jones-Gotman M, Gotman J. Duration of sodium amytal effect: behavioral and EEG measures. Epilepsia 1993;34:61-68 https://doi.org/10.1111/j.1528-1157.1993.tb02376.x
  28. Price CJ, Wise RJ, Watson JD, Patterson K, Howard D, Frackowiak RS. Brain activity during reading. The effects of exposure duration and task. Brain 1994;117:1255-1269 https://doi.org/10.1093/brain/117.6.1255
  29. Frith CD, Friston KJ, Liddle PF, Frackowiak RS. A PET study of word finding. Neuropsychologia 1991;29:1137-1148 https://doi.org/10.1016/0028-3932(91)90029-8
  30. Wise R, Chollet F, Hadar U, Friston K, Hoffner E, Frackowiak R. Distribution of cortical neural networks involved in word comprehension and word retrieval. Brain 1991;114:1803-1817 https://doi.org/10.1093/brain/114.4.1803
  31. Binder JR, Rao SM, Hammeke TA, Yetkin FZ, Jesmanowicz A, Bandettini PA, et al. Functional magnetic resonance imaging of human auditory cortex. Ann NeuroI 1994;35:662-672 https://doi.org/10.1002/ana.410350606
  32. Warburton E, Wise RJS, Price CJ. Weiller C, Harda U, Ramsay S, et al. Noun and verb retrieval by normal subjects studies with PET. Brain 1996;119:159-179 https://doi.org/10.1093/brain/119.1.159
  33. Deutsch G, Papanicolaou AC, Bourbon T, Eisenberg HM. Cerebral blood flow evidence of right cerebral activation in attention demandingtasks. Int J Neurosci 1988;36:23-28 https://doi.org/10.3109/00207458709002136
  34. Pardo JV, Fox PT. Raichle ME. Localization of a human system for sustained attention by positron emission tomography. Nature 1991;349:61-64 https://doi.org/10.1038/349061a0