Journal of Korean Academy of Oral Health

The Korean Academy of Preventive Dentistry and Oral Health (대한예방치과·구강보건학회)
권호 표지

A highly selective antibacterial effect of Curcuma xanthorrhiza extract against oral pathogens and clinical effectiveness of a dentifrice containing Curcuma xanthorrhiza extract for controlling bad breath

Curcuma xanthorrhiza 추출물 및 함유 치약의 구취 억제 효과와 구강 유해균에 대한 선택적 항균 효과

Kim, Baek-Il;Kim, Sang-Nyun;Chang, Sug-Youn;Moon, Kyo-Tae;Kim, Yun-Seog;Hwang, Jae-Kwan;Jeong, Seung-Hwa;Kim, Min-Young;Kim, Hae-Sun;Kwon, Ho-Keun
김백일;김상년;장석윤;문교태;김윤석;황재관;정승화;김민영;김해선;권호근

  • Published : 2005.06.30
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Abstract

Objectives: The aim of this study was to detennine potential for developing oral hygiene products containing Curcuma xanthorrhiza extract (Cx) of which antibacterial activity against cariogenic mutant streptococci and G( -) anaerobic bacteria with odorigenic and periopathogenic capacity has been published, Methods: With growing concerns about synthetic antibacterials, a concept of a selective antibacterial activity of Cx against mutants streptococci while showing a minimal damage on normal flora was developed, The minimal bactericidal concentrations exerted by Cx and triclosan to mutants streptococci and aerobic nonnal flora were detennined from the concentrations in which no bacteria survived on either MS agar or BHI agar, respectively, The substantive antibacterial activity on the tooth surface was compared by adopting a protocol that cleansed bovine teeth/hydroxyapatite pretreated with Cx, chlorhexidine, ticlosan and fluoride were layered with soft agar containing S. sobrinus, sucrose, and phenol red as a pH indicator and incubated for their residual activity, The effectiveness of a dentifrice containing Cx for controlling breath odor was evaluated by a panel of two judges using a nine-point hedonic scale, Two separated sets of clinical designs, a double blind, cross over of 16 subjects for short tenn effect and a double blind 3 day nonbrushing model using 71 subjects for long-tenn effect were perfonned to evaluate clinical effects on bad breath. Results: The Cx exhibited a highly selective activity against mutants streptococci with almost no effect on aerobic nonnal flora upto 1,000 ppm, while triclosan did show a strong effect on bacteria without discrimination. The greater substantive Cx proved by both bovine teeth and HA disk was considered as a promise for dentifrice and mouthwash application. The results of two clinical study support the conclusion that dentifrice with Cx provides effective control of bad breath compared to placebo dentifrice. Conclusions: Altogether, Cx with a highly selective antibacterial activity appears to be an attractive candidate as a replacement for chemicals and oral hygiene products with Cx will be a new paradigm delivering natural benefit for consumers.

Keywords

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