The Results and Usefulness of Marker Clip Placement after Ultrasound-guided Mammotome Excision of Breast Lesion

유방병변의 초음파 유도하 맘모톰 절제 후 표식자 삽입의 결과와 그 유용성

Lee, So-Youn;Kook, Shin-Ho;Kwag, Hyon-Joo
이소연;국신호;곽현주

  • Published : 20050300

Abstract

Purpose: We wanted to know the results and the usefulness of placing a marker clip (a surgical titanium clip) after ultrasound (US)-guided excisional mammotome biopsy for breast lesion. Materials and Methods: We have placed marker clips at the biopsy sites after performing US-guided excisional mammotome biopsies in 24 cases (mean age; 46 years, mean size of the 12.6 mm, pathologic results; benign in 19 cases, malignant in 5 cases) from Nov. 2003 to Jun. 2004. We designed the needle that we used. Twenty-five cases of follow-up sonography (at 1-month follow-up; 13 cases, at 6-months follow-up; 12 cases) were performed for 18 cases of clip placement. We retrospectively reviewed the success rate and the complications for 24 cases of clip placement, and we analyzed the visibility, conspicuity and location of the clips on 25 cases of follow-up sonography for 18 cases of clip placement. Results: The marker clip is successfully placed in all 24 cases (100%). None of the patients complained of pain or infection, except for 1 case of a large hematoma (3.5 cm). On the follow-up sonography, the titanium clip was well visualized as a short echogenic line on the interval follow-up (for the 1-month follow-up; 85%, for the 6 month follow-up; 84%) and parenchymal composition of the breast was well observed at the location of the clip (intraparenchymal; 80%, parenchyma-fat interface; 90%). The clips were easily found when there was hematoma (85%) or scar (89%). Marker clips were found within the hematoma, scar or the distorted region of tissue in all cases (100%), and there was no evidence of migration on the post-biopsy findings.

목적: 유방병변의 초음파 유도하 맘모톰 절제 생검 후 외과용 표식자(clip) 삽입의 결과와 유용성 알아보고자 하였다. 대상과 방법: 2003년 11월부터 2004년 6월까지 본원에서 맘모톰 절제 생검을 한 24예(평균연령; 46세, 평균 크기; 12.6 mm, 병리 조직검사 결과; 양성 19예, 악성 5예) 의 병변을 대상으로 저자들이 자체 제작한 바늘을 사용하여 외과용 티타늄 표식자를 병변 제거 부위에 삽입하였다. 표식자를 삽입하였던 24예 중 18예에서 초음파 추적 검사를 25회(1개월 이내; 13예, 6개월; 12예) 실시하였다. 총 24예에 대한 티타늄 표식자 삽입 성공율, 삽입 후 합병증과 18 예의 25회 추적 초음파 검사에서 표식자 확인의 용이성 및 명확도, 표식자 위치를 후향적으로 분석하였다. 결과: 총 24예 모두 목적한 위치에 표식자의 삽입에 성공하였으며(100%), 통증이나, 시술 부위의 감염은 없었으나 1예에서 큰 혈종(3.5 cm)을 형성하였다. 초음파 추적 검사에서 티타늄 표식자는 추적 기간(1개월 내; 85%, 6개월; 84%) 및 해부학적 구성 성분 부위(실질 내; 80%, 실질-지방 경계부; 90%)에 관계없이 밝은 에코의 선상 구조물로 명확히 관찰되었다. 추적 검사에서 혈종(85%)과 반흔(89%)이 있는 경우에도 표식자 발견이 용이하였고, 표식자는 전 예에서 병변, 혈종, 반흔, 왜곡 등의 소견 부위에서 위치하여 다른 부위로 이동되어 있는 경우는 없었다. 결론: 초음파 유도하 맘모톰 절제 후 티타늄 표식자 삽입은 적은 비용으로 간편하게 시술할 수 있었고, 100% 성공율을 보였으며 동반된 합병증이 거의 없었다. 또한 추적 검사에서 모든 표식자가 잘 보였으며, 절제 생검 부위 내에 위치하여 임상적 적용에 유용하였다.

Keywords

References

  1. Simon JR, Kalbhen CL, Cooper RA, Flisak ME. Accuracy and complication rates of US-guided vacuum-assisted core breast biopsy: initial results. Radiology 2000;215:694-697 https://doi.org/10.1148/radiology.215.3.r00jn37694
  2. March DE, Coughlin BF, Barham RB, Goulart RA, Klein SV, Bur ME, et al. Breast mass; removal of all US evidence during biopsy by using a handheld vacuum-assisted device-initial experience. Radiology 2003;227:549-555 https://doi.org/10.1148/radiol.2272020476
  3. Pandelidis S, Heiland D, Jones D, Stough K, Trapeni J, Suliman Y. Accuracy of 11-gauge vacuum-assisted core biopsy of mammographic breast lesions. Ann Surg Oncol 2003;10:43-47 https://doi.org/10.1245/ASO.2003.05.004
  4. Edeiken BS, Fornage BD, Bedi DG, Singletary SE, Ibrahim NK, Holmes F, et al. US-guided Implantation of Metallic Markers for Permanent Localization of the Tumor Bed in Patients with Breast Cancer Who Undergo Preoperative Chemotherapy. Radiology 1999; 213:895-900 https://doi.org/10.1148/radiology.213.3.r99dc34895
  5. Margolin FR, Jacobs RP, Denny SR, Schrumpf JD. Clip placement after sonographically guided percutaneous breast biopsy. Breast J 2003;9:226-230 https://doi.org/10.1046/j.1524-4741.2003.09319.x
  6. Parker SH, Klaus AJ, McWey PJ, Schilling KJ, Cupples TE, Duchesne N, et al. Sonographically guided directional vacuum-assisted breast biopsy using a handheld device. AJR Am J Roentgenol 2001;177:405-408 https://doi.org/10.2214/ajr.177.2.1770405
  7. Fine RE, Boyd BA, Whitworth PW, Kim JA, Harness JK, Burak WE. Percutaneous removal of benign breast masses using a vacuum- assisted hand-held device with ultrasound guidance. Am J Surg 2002;184:332-336 https://doi.org/10.1016/S0002-9610(02)00951-0
  8. Johnson AT, Henry-Tillman RS, Smith LF, Harshfield D, Korourian S, Brown H, et al. Percutaneous excisional breast biopsy. Am J Surg 2002;184:550-554 https://doi.org/10.1016/S0002-9610(02)01099-1
  9. Brem RF, Schoonjans JM, Goodman SN, Nolten A, Askin FB, Gatewood OM. Nonpalpable breast cancer: percutaneous diagnosis with 11- and 8-gauge stereotactic vacuum-assisted biopsy devices. Radiology 2001;219:793-796 https://doi.org/10.1148/radiology.219.3.r01jn34793
  10. Jackman RJ, Birdwell RL, Ikeda DM. Atypical Ductal Hyperplasia: can some lesions be defined as probably benign after stereotactic 11-gauge vacuum-assisted biopsy, eliminating the recommendation for surgical excision? Radiology 2002;224:548-554 https://doi.org/10.1148/radiol.2242011528
  11. Burbank F, Forcier N. Tissue marking clip for stereotactic breast biopsy: initial placement accuracy, long-term stability, and usefulness as a guide for wire localization. Radiology 1997;205:407-415 https://doi.org/10.1148/radiology.205.2.9356621
  12. Kaplan SS, Racenstein MJ, Wong WS, Hansen GC, McCombs MM, Bassett LW. US-guided core biopsy of the breast with a coaxial system. Radiology 1995;194:573-575 https://doi.org/10.1148/radiology.194.2.7824740
  13. 김선미, 박정미, 이상현, 한 헌, 송호영, 신지훈, 등. 유방병변에 대한 맘모톰 절제 후 삽입하는 새로운 금속 위치 표식자에 대한 대한 초기 경험. 대한초음파의학회지 2003;22:223-231
  14. Margolin FR, Kaufman L, Denny SR, Jacobs RP, Schrumpf JD. Metallic marker placement after stereotactic core biopsy of breast calcifications: comparison of two clips and deployment techniques. AJR Am J Roentgenol 2003;181:1685-1690 https://doi.org/10.2214/ajr.181.6.1811685
  15. Margolin FR, Jacobs RP, Denny SR, Schrumpf JD. Clip placement after sonographically guided percutaneous breast biopsy. Breast J 2003;9:226-230 https://doi.org/10.1046/j.1524-4741.2003.09319.x
  16. Kubota K, Gomi N, Wakita T, Shibuya H, Kakimoto M, Osanai T. Magnetic resonance imaging of the metal clip in a breast: safety and its availability as a negative marker. Breast Cancer 2004;11:55-59 https://doi.org/10.1007/BF02968003
  17. Burnside ES, Sohlich RE, Sickles EA. Movement of a biopsy-site marker clip after completion of stereotactic directional vacuum-assisted breast biopsy: case report. Radiology 2001;221:504-507 https://doi.org/10.1148/radiol.2212010565
  18. Philpotts LE, Lee CH. Clip migration after 11-gauge vacuum-assisted stereotactic biopsy: case report. Radiology 2002;222:794-796 https://doi.org/10.1148/radiol.2223011263
  19. Liberman L, Dershaw DD, Morris EA, Abramson AF, Thornton CM, Rosen PP. Clip placement after stereotactic vacuum-assisted breast biopsy. Radiology 1997;205:417-422 https://doi.org/10.1148/radiology.205.2.9356622
  20. Rosen EL, Baker JA, Soo MS. Accuracy of a collagen-plug biopsy site marking device deployed after stereotactic core needle breast biopsy. AJR Am J Roentgenol 2003;181:1295-1299 https://doi.org/10.2214/ajr.181.5.1811295