Pediatric allergy and respiratory disease (소아알레르기 및 호흡기학회지)

The Korean Academy of Pediatric Allergy and Respiratory Diseasse (대한소아알레르기호흡기학회)
권호 표지

Risk Factors of Moderate to Severe Atopic Drmatitis in the First 6 Months of Life

생후 6개월 이하의 중등증 및 중증 아토피피부염 환자에서 위험요인 분석

Ahn, So-Hyun;Seo, Won-Hee;Kim, Su-Jung;Hwang, Su-Jung;Park, Hwa-Young;Han, Young-Shin;Chung, Sang-Jin;Lee, Hee-Chul;Ahn, Kang-Mo;Lee, Sang-Il
안소현;서원희;김수정;황수정;박화영;한영신;정상진;이희철;안강모;이상일

  • Published : 20050000
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Abstract

Purpose:The aim of this study was to analyze the risk factors of moderate to severe atopic dermatitis(AD) in the first 6 months of life. Methods:Children aged less than 6 months with AD were divided into two groups according to Six Area, Six Sign Atopic Dermatitis(SASSAD) Score. Children with scores of less than 14 were classified as Mild AD(n=90) and above 15 as Moderate to Severe (Mod-severe) AD(n=44). These patients were fed with breast milk or cow's milk formula, and no allergenic food was given except rice and some vegetables. We analyzed the gender, feeding patterns, family history of allergy, number of siblings, total IgE and specific IgE to common food allergens(egg white, cow's milk, soy, wheat) by CAP assay(Pharmacia, Uppsala, Sweden). Results:Total IgE was 180.6±44.7 U/mL in mod-severe AD and 32.2±6.1 U/mL in mild AD(P=0.002). Specific IgE to egg white, soy and wheat(19.03±4.48 U/mL; 7.07±0.40 U/mL, 4.68±1.89 U/mL in mod-severe AD; 1.78±0.43 U/mL, 0.09±0.03 U/mL, 0.15±0.11 U/mL in mild AD; P<0.05) were associated with mod-severe AD, but cow's milk(4.34±2.50 U/mL in mod-severe AD; 0.80±0.44 U/mL in mild AD) showed no statistical difference. Gender, feeding patterns, family history and number of siblings were not significantly associated with mod-severe AD. The total IgE level and egg white specific IgE level significantly increased as the duration of breast feeding increased(P<0.05). Conclusion:Mod-severe atopic dermatitis in the first 6 months of life is associated with sensitization to food allergens, which might be transferred via breast milk. [Pediatr Allergy Respir Dis(Korea) 2005;15:242-249]

Keywords

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