Journal of Environmental Health Sciences (한국환경보건학회지)

Korean Society of Environmental Health (한국환경보건학회)
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Prevention of Ultraviolet B Radiation (280-320 nm) Induced Contact Hypersensitivity by EGb 761

ICR mouse에 있어 UVB조사로 유도된 접촉 과민반응에 대한 EGb 761의 억제 효과

  • Choi, Wook-Hee (Department of Health Science, Dongduk Women's University) ;
  • Ann, Hyoung-Soo (Department Pharmacology, Dongduk Women's University) ;
  • Ahn, Ryoung-Me (Department of Health Science, Dongduk Women's University)
  • 최욱희 (동덕여자대학교 보건관리학과) ;
  • 안형수 (동덕여자대학교 약학과) ;
  • 안령미 (동덕여자대학교 보건관리학과)
  • Published : 2005.03.01
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Abstract

Exposure of skin to UVB radiation can cause the induction of inflammation and impairment of contact hypersensitivity(CHS) response. Several studies have shown that polyphenolic compounds isolated from EGb 761 afford protection against UVB. In this study, we demonstrated that topical application of EGb 761, before 1MED(1.4 KJ/$m^2$), 1.5MED (2.1 KJ/$m^2$), 2MED (2.8 KJ/$m^2$) of UVB exposure to ICR mice prevented UVB-induced inflammation and inhibition of the contact hypersensitivity response. The skin-fold swelling from 1MED, 1.5MED, 2MED of UVB exposure highly significantly increased after twice irradiation. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to UVB exposure reduced skin thickness compared to non-treated mice. Exposure of shaved abdominal skin of mice to 1MED, 1.5MED and 2MED of UVB radiation resulted in suppression of contact sensitization through the skin to 56.23%, 65.12%, 74.02%, compared to normal unirradiated skin. Topical application of EGb 761(0.1%, 1%, 4%), 5 days prior to or 5 days after exposure to 1MED and 2MED of UVB resulted in protection against suppression of contact hypersensitivity in mouse dorsal skin. These protective effects were dependent on the dose of EGb 761 employed. The present study show that EGb 761 protect UVB-induced inflammation and immune suppression. Also, we suggest that EGb 761 can provide protection from photoimmunosuppression.

Keywords

References

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