Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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Effects of Nelumbo nucifera on the Regional Cerebral Blood Flow and Blood Pressure in Rats

연근의 열수 추출물이 흰쥐의 국소 뇌혈류량과 혈압에 미치는 영향

  • Park Sung-Hye (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Sihn Eon-Hwan (Dept. of Hotel Culinary Arts, Ulsan College) ;
  • Koo Jae-Geun (Faculty of Applied Ocean Science and Technology, Kunsan National University) ;
  • Lee Tae-Hun (R & D Center, Dongwon F & B Co.) ;
  • Han Jong-Hyun (Dept. of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • 박성혜 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 신언환 (울산과학대학 호텔조리과) ;
  • 구재근 (군산대학교 해양응용공학부 식품공학전공) ;
  • 이태헌 (동원 F & B (주) 식품연구소) ;
  • 한종현 (원광대학교 한의학전문대학원 한약자원개발학과)
  • Published : 2005.02.01
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Abstract

The purpose of this study was to measure the changes of regional cerebral blood flow(rCBF) and blood pressure(BP) in rats, following the intravenous injection of Nelumbo nucifera water extract. The measurement was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Sprague-Dawley rats for about 2 to 2 and half hours through the data acquisition system composed of MacLab and Macintosh computer. The results of this experiment were as follows. Nelumbo nucifera significantly increased the changes of rCBF in rats. The rCBF of Nelumbo nucifera was not changed by pretreated propranolol, atropine, L-NNA and indomethacin. But the rCBF of Nelumbo nucifera was decreased by pretreated methylene blue. Nelumbo nucifera decreased the BP significantly. The BP of Nelumbo nucifera was not changed by pretreated propranolol, atropine, L-NNA and indomethacin. But the BP of Nelumbo nucifera was decreased by pretreated methylene blue. These results indicated that Nelumbo nucifera might increase the rCBF and decrease the BP which related to guanylyl cyclase activity.

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