The Journal of Korean Obstetrics and Gynecology (대한한방부인과학회지)

The Society of Korean Medicine Obstetrics and Gynecology (대한한방부인과학회)
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Effect of Saururi Herba Seu Rhizoma on anti-inflammatory properties in RAW264.7 cell line and murine models of inflammation

삼백초(三白草)의 소염작용(消炎作用)에 대(對)한 실험적(實驗的) 연구(硏究)

  • Byun, Hyung-Kuk (Dept. of Ob & Gyn College of Oriental Medicine, Daejeon Univ) ;
  • Shin, Yong-Wan (Dept. of Ob & Gyn College of Oriental Medicine, Daejeon Univ.) ;
  • Kim, Eui-Il (Dept. of Ob & Gyn College of Oriental Medicine, Daejeon Univ.) ;
  • Kim, Su-Min (Dept. of Ob & Gyn College of Oriental Medicine, Daejeon Univ.) ;
  • Lee, Jung-Eun (Dept. of Ob & Gyn College of Oriental Medicine, Daejeon Univ.) ;
  • Yoo, Dong-Youl (Dept. of Ob & Gyn College of Oriental Medicine, Daejeon Univ.)
  • 변형국 (대전대학교 한의과대학 부인과학교실) ;
  • 신용완 (대전대학교 한의과대학 부인과학교실) ;
  • 김의일 (대전대학교 한의과대학 부인과학교실) ;
  • 김수민 (대전대학교 한의과대학 부인과학교실) ;
  • 이정은 (대전대학교 한의과대학 부인과학교실) ;
  • 유동열 (대전대학교 한의과대학 부인과학교실)
  • Published : 2005.11.30
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Abstract

Purpose : The purpose of this research was to investigate the effects of Saurui Herba Seu Rhizoma(SHSR) on Anti-inflammatory properties in Raw264.7 cell line and murine models of inflammation. Methods : To investigate the effects of Saurui Herba Seu Rhizoma(SHSR) on anti-inflammation, we study cytotoxicity effects of SHSR on Mouse Lung Fibroblast Cells and Peritoneal Macrophages, Inhibitory effects of SHSR on the nitric oxide (NO) release, the ROS production, and the interleukin-6 production. Results : The cytotoxicity of SHSR on mouse lung fibroblast Cells and Raw264.7 cell line was not observed. SHSR in RAW264.7 cell line inhibited $IL-1{\beta}$, IL-6 mRNA gene expression depending upon the concentrations of extract and inhibited IL-18 mRNA gene expression at 100 ${\mu}g/ml$ of extract. SHSR in RAW264.7 cell line inhibit COX-2 mRNA gene expression at 100, 10 ${\mu}g/ml$ of extract. SHSR in RAW264.7 cell line inhibited NOS-II mRNA gene expression depending upon the concentrations of extract. SHSR in RAW264.7 cell line didn't inhibit $TNF-{\alpha}$ mRNA　gene expression. SHSR in RAW264.7 cell line decreased IL-6 production depending　upon the concentrations of extract. SHSR in RAW264.7 cell line decreased $ITNF-{\alpha}$ production according to the concentrations of extract. SHSR in RAW264.7 cell line inhibited NO release specially SHSR 100, 10 ${\mu}g/ml$ concentrations of extract. SHSR inhibit ROS production depending upon the concentrations of extract. Conclusion : These results suggest that SHSR can be used treating a lot of women disease caused by inflammation.

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