The Korean Journal of Cytopathology (대한세포병리학회지)

The Korean Society for Cytopathology (대한세포병리학회)
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Clinical Efficacy of Manual Liquid-Based Cervicovaginal Cytology Preparation: Comparative Study with Conventional Papanicolaou Test

수기 액상세포검사를 이용한 자궁목 세포진 검사의 임상적 효용성: 고식적 세포진 검사와의 비교

  • Park, Jong-Myoung (Department of Cytopathology, Sung-Yoon Reference Laboratory) ;
  • Lee, Jong-Gi (Department of Cytopathology, Sung-Yoon Reference Laboratory) ;
  • Suh, In-Soo (Department of Pathology, Kyungpook National University School of Medicine)
  • 박종명 (성윤검사센타 세포학부) ;
  • 이종기 (성윤검사센타 세포학부) ;
  • 서인수 (경북대학교 의과대학 병리학교실)
  • Published : 2005.05.31
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Abstract

This study was performed to compare manual liquid-based preparation with conventional Papanicolaou tests in view of the cytologic diagnoses and specimen adequacy. The specimens of 5,979 women from 33 local clinics and 1 general hospital were prepared by both manual liquid-based preparation and conventional Papanicolaou test. The cytologic diagnoses and specimen adequacy were evaluated in Department of Fathology in Kyoungpook National University School of Medicine. A conventional Papanicolaou test was always prepared first, after that residual material on the sampling device was rinsed into a liquid preservative, and then thin-layer slides were prepared using manual method of liquid-based cervicovaginal cytology. Conventional and liquid-based slides were read independently, and cytologic diagnoses and specimen adequacy were classified using the Bethesda System. Of the cases, 5,763 (96.3%,) had the same interpretation, and there was no significant diagnostic difference in 5,853 (97.8%) cases. When evaluating cases with more than one diagnostic class difference, the manual liquid-based preparation demonstrated a statistically significant overall improvement (2.1%) in the detection of squamous intraepithelial lesion and invasive cancer. Using manual method of liquid-based preparation, there was 14.1%, reduction in unsatisfactory slides through excellent cellular presentation. In conclusion, the manual liquid-based preparation produces standardized quality, superior sensitivity and improved adequacy as compared to the conventional method.

Keywords

References

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