Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
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Antidiabetic and Antioxidative Effects of Corni fructus In Streptozotocin-Induced Diabetic Rats

산수유 추출물이 Streptozotocin으로 유발된 흰쥐의 항당뇨 및 항산화 작용에 미치는 효과

  • Kim, Ok-Kyung (Department of Food Science and Nutrition, Dae Jin University)
  • 김옥경 (대진대학교 자연과학대학 식품영양학과)
  • Published : 2005.06.30
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Abstract

The extraction yield of Corni fructus was about 47.5% by extract apparatus. This study was done to investigate the antidiabetic and antioxidative effects of Corni fructus in Streptozotocin (STZ)-induced diabetic rats. The contents of serum glucose, total cholesterol and hepatic lipid peroxide, glutathione were significantly decreaed (p<0.05) in Corni fructus treated group compared to the those of STZ-control group, also content of triglyceride (TG), atherogenic index (AI) and activity of catalase were decreased, but not statistically significant. High density lipoprotein (HDL)-cholesterol and HDL-cholesterol/total cholesterol ratio (HTR) were increased in Corni fructus treated group compared to the those of STZ-control group. The activities of glutathione-S-transferase (GST) and superoxide dismutase (SOD) were significantly decreaed (p<0.05) in Corni fructus treated group compared to the those of STZ-control group. The content of hepatic glycogen and activities of glucose-phosphate dehydrogenase (G-6 PDH), glucokin-ase were significantly increased, but activity of glucose-Grphosphatase (G-6 Pase)was decreased in Corni fructus treated group compared to the those of STZ-control group. Therefore, these results indicated that ethanol extract of Corni fructus would have antidiabetic and antioxidative effects in STZ-induced diabetic rats.

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References

  1. Korea National Statistical Office. The Cause of Death Statistics (2003)
  2. C. S. Moody and H. M. Hassan, Mutagenicity of Oxygen Free Radicals. Proc. Natl. Acsd. SCI., 79, 2855 (1982)
  3. V. B. C. Junqueira, K Simiz, L. A. Videla and S. B. Barros, Dose Dependent Study of the Effects of Acute Lindamce Administration on Rat Liver Superoxide Anion Production Antioxidant Enzyme Activities and Lipid Peroxidation. Toxicology, 41, 193 (1996) https://doi.org/10.1016/0300-483X(86)90199-X
  4. H. M. Hassan, Free Radical. BioI. Med., 5, 377 (1988)
  5. T. Byers and G. Perry, Dietary Carotenes, Vitamin C and Vitamin E as Protective Antioxidants in Human Cancers. Ann. Rev. Nutr., 12, 135 (1992)
  6. E. S. Tai, S. D. Lim, B. Y. Tan, S. K Chew, D. Heng and C. E. Tan, Screening for Diabetes Mellitus : A Two-Step Approach in Individuals with Impaired Fasting Glucose Improves Detection of Those at Risk of Complications Diabetes Med., 17, 771 (2000)
  7. I. C. West, Radicals and Oxidative Stress in Diabetes. Diabet Med., 17, 171(2000)
  8. K. S. Lee, B. S. Bae, M. J. Bae, M. A. Jang, J. S. Seo and Y. S. Choi, Effect of Sea Tangle and Metformin on Lipid Peroxide and Antioxidant Levels In Diabetic Rats. The Korean Nutrition Society, 32, 230 (1999)
  9. S. J. Lim, J. G. Jeong, M. W. Kim, S. S. Choi, H. K. Han and M. W. Kim Effects of Benincasa hispida Intake on Blood Glucose and Lipid Level In Streptozotocin Induced Diabetic Rats. J. Korean Soc. Food Sci. Nutr., 36, 335 (2003)
  10. M. Latha and L. Pari, Modulatory effect of Scoparia dulcis in oxidative Stress-Induced Lipid Peroxidation In Streptozotocin Diabetic Rats. J. Med. Food, 6, 379 (2003)
  11. M. D. Ivorra, M. Paya, A. Villar, A Review of Natural Products and Plants as Potential Antidiabetic Drugs. J. Ethnopharmacol., 27, 23 (1989)
  12. S. R. Chung, K. H. Jeune, S. Y. Park and S. J. Jang, Toxicity and Lectins Constituents from the Seed of Comus officinalis, Korean J. Pharmacogn, 24, 177 (1993)
  13. K. I. Seo, S. W .Lee and K. H. Yang, Antimicrobial and Antioxidative Activities of Corni fructus Extracts. Korean J. Postharvest Sci. Technol.. 6, 99 (1999)
  14. T. Guilian, T. Zhang, F. Yang and Y. Ita, Separation of Gallic Acid from Comus officinalis Sieb. et Zucc by High Speed Counter Current Chromatography. J. Chromatogr., A. 886, 309 (2000)
  15. J. Yamahara, H. Mibu, T. Sawada, H. Fujimura and S. Takino, Antidiabetic Principles of Lomi fructus Experimental Diabetes Induced by Streptozotocin. Yakugaku Zasshi, 101, 86 (1981)
  16. Y. K. Park, W. K. Whang and H. I. Kim, The Antidiabetic Effects of Extract from Comus officinalis Seed. Chung-Ang J. Plurm Sci., 9, 5 (1995)
  17. Y. Dai, B. Hang, and Z. Huang, Inhibition of Corni fructus on experimental inflammation. Chung Kuo Chung Yao Ts Chih 17, 307 (1992)
  18. D. H. Won, J. H. Cho, H. S. Kim, J. H. Ko, J. Lee, S. A. Park, H. J. Lee, C.S.Yook, I. H. Kim and B. P. Won, Studies on the Analysis of Corni fructus and Its Preparation. The Annual Report KDFA, 1, 197 (1996)
  19. H. Jeng, C. M. Wu, S. J. Su and W. C. Chang, A Substance Isolated from Comus officinalis Enhances the Rotility of Human Sperm. Am J. Chinese Med., 25, 301 (1997)
  20. Q. Peng, Z. Wei and B. Lau, Medical Plants Research Corni fructus Attenuates Oxidative Stress in Macrophages and Endothelials Cells Am J. Chinese Med., 26, 291 (1998) https://doi.org/10.1142/S0192415X98000336
  21. H. K. Joo and D. J. Jang, Effets of Shanshuyu( Comus Officinalis Sieb) Tea and Market Teas Feeding on the Hepatology and Liver Function of Rat. Korean J. Dietary Culture, 4, 257 (1989)
  22. Y. C. Lee, Y. E. Kim, B. Y. Lee and C. J. Kim, Chemical Compositions of Corni Fructus and Separating Properties of Its Flesh by Drying. Korean J. Food Sci. Technol., 24, 447 (1992)
  23. Y. D. Kim, H. K. Kim and K. J. Kim, Analysis of Nutritional Comp.nents of Comus officianalis. J. Korean Soc. Food Sci. Nutr., 32, 783 (2003)
  24. B. H. Kim, K. W. Park, J. Y. Kim, I. Y. Jeong, C. H. Yang, Y. S. Cho, S. T. Yee and K. I. Seo, Purification and Characterization of Anticarcinogenic Co mpound from Corni fructus. Korean J. Food Technol.. 36, 1001 (2004)
  25. O. K. Kim, The Effects of Sedum sarmentosum Bunge Extract Using Super Critical Carbon Dioxide on Lipid Metabolism, Lipid Peroxidation and Antioxidation in Carbon Tetrachloride Induced Hepatotoxicity in Rats J. of Korean Oil Chem. Soc., 21, 204 (2004)
  26. O. K. Kim, Antidiabetic Effect of Glechoma hederacea LINNAEUS m Streptozotocin-Induced Diabetic Rats Kor. J. Pharmacogn., 35, 300 (2004)
  27. P.N. Pushparaj, B.K.H. Tan and c.H. Tan, The Mechanism of Hypoglycemic action of the Semi-purified Fraction of Averrhoa bilimbi in Streptozotocin-Diabetic rats. Life Sciences, 70, 535 (2001)
  28. R. B. Goldberg, Lipid Disorders m Diabetes. Diabetes Care, 4, 561(1981)
  29. S. Y. Cho, J. Y. Park, E. M. Park, M. S. Choi and M. K. Lee, Alternation of Hepatic Antioxidant Enzyme Activities and Lipid Profile m Streptozotocin Induced Diabetic Rats by Supplementation of Andelion Water Extract. Clin Chim Acta, 317, 109 (2002)
  30. K. M. West, M. M. Ahuja and P. H. Bennett, The Role of Circulating Glucose and Triglyceride Concentration and Their Interaction With Other 'Risk Factor' as Determinants of Arterial Disease in Nine Diabetic Population Samples from WHO Multinational Study. Diabetes Care, 6, 361 (1983)
  31. M. A. Bang, Y. J. Cho and H. A. Kim, Effect of Indongcho on Glucose and Lipid Metabolism and Antioxidative Enzyme System in Streptozotocin Induced Diabetic Rats. Korean J. Dietary Culture., 17, 377 (2002)
  32. S. J. Lim, J. G. Jeong, M. W. Kim and S. S. Choi, Effects of Benincasa hispida Intake on Blood Glucose and Lipid Level in Streptozotocin Induced Diabetic Rats. J. Korean Sac. Food Sci. Nutr., 36. 335 (2003)
  33. I. S. Lee, S. O. Lee and I. Z. Lee, Effects of Tissue Cultured Ginseng on Blood Glucose and Lipids m Streptozotocin Induced Diabetic Rats. Korean J. Food Sci. Technol., 35, 280 (2003)
  34. S. Z. Lee, S. H. Park and H. S. Lee, Changes in Vivo Lipid Peroxidation and Antioxidation Defense in Streptozotocin Induced Rats : A Time Course Study. The Korean Nutrition Society., 34, 253 (2001)
  35. S. Celik, G. Baydas, O. Yilaz, Influence of Vitamin E on the Levels Fatty Acids and MDA in Some Tissues of Diabetic Rats. Cell Biochem Funct., 20, 67 (2002)
  36. K. S. Lee, Y. S. Choi and J. S. Seo, Sea Tangel Supplementation Lowers Blood Glucose and Supports Antioxidant Systems in Streptozotocin Induced Diabetic Rats. J. of Medicanal Food, 7, 130 (2004)
  37. H. K. Han, Effects of Alisma mnaliculatum Butanol Fraction with Vitamin E on Glycogen, Lipid Levels, and Lipid Peroxidation in Streptozotocin Induced Diabetic Rats. Korean J. Food Sci. Technol., 36, 467 (2004)
  38. I. Frielovich, The Biology of Oxygen Radicals. the Superoxide Radical as an Agent of Oxygen Toxicity : Superoxide Dismutase Provides an Important Defense. Science, 201, 875 (1978)
  39. Y. Levy, H. Za : atsberg, A. BenAmotz, Y. Kanter, M. A viram, Diatary Supplementation of a Natural Isomer Mixture of Beta-Carotone Inhibits Oxidation of LDL Derived from Patients with Diabetes Mellitus. Ann. Nutr. Metab., 44, 54 (2000)
  40. M. Kinalsaki, A. Sledziewski, B. Telejko, W. Zarzycki, I. Kinalska, Lipid Peroxidation and Scavenging Enzyme Activity in Streptozotocin-Induced Diabetes Acta Diabetol., 37, 179 (2000)
  41. G. M. Cohen, and R. B. Freedom, Roles and Functions of Glutathione. Biochem Soc. Trans., 10, 78 (1982)
  42. A. Meister, Selective Modification of Glutathione Metabolism. Science. 220, 472 (1983)
  43. C. Agius, and A. S. Gidari, Effect of Streptozotocin on the Glutathione S-transferases of Mouce Liver Cytosol. Biochem Pmrmacol., 34, 811 (1985)
  44. M. Latha, and L. Pari, Modulatory Effect of Scoparia dulcis in Oxidative StressInduced Lipid Peraxidation In Streptozotocin Diabetic Rats. J. Med Food, 6, 379 (2003) https://doi.org/10.1089/109662003772519958
  45. R. M. Vos and P.J. Van Bladem, Glutathione-S-transferase in Relation to Their Role in the Biotransformation of Xenobiotics. Chem. Biol. Interact., 75, 241 (1990) https://doi.org/10.1016/0009-2797(90)90069-Y
  46. C. H. Crapo, J. M. McCord, and E. Fridovich, Preparation and Assay of Superaxide Dismutase. In Methods In Enzymology, Fleischer, D. and Packer, L.(eds.), Academic Press, 52, 382 New York (1978)
  47. R. Kakkar, J. Kalra,, S. V. Mantha and K. Prasod, Lipid Peroxidation and Activity of Antioxidant Enzymes in Diabetic Rats. Molecular and Celluar Biochemistry. 151, 113 (1995)
  48. A. Deisseroth and A. L. Dounce, Catalase Physical and Chemical Properties, Mechanism of Catalysis and Physiological Role. Physiol. Rev. 50, 3 (1970)
  49. Y. E. Chung, S. W. Kim, J. Y. Lim, E. S. Kim and J. Y. Park, Effect of Decreased Plasma Glucose Free Fatty Acids by an Antilipolytic Agent on Plasma Glucose Level and Liver Glycogen Content in Streptozotocin Induced Diabetic Rats. The Korean diabetic society, 23, 46 (1999)
  50. M. D. Meglasson, T. P. Burch, D. K. Berner, H. Najafi and F. M. Matschinsky, Identification of Glucokinase as an Alloxan Sensitive Glucose Sensor of the Pancreatic ${\beta}$-cell. Diabetes, 35, 1163 (1986)
  51. R. Ghosh, B. Mukherjee and M. A. Chattejee, Novel Effect of Selenium on Streptozotocin Induced Diabetic Mice. Diabetes Res., 25, 165 (1994)
  52. Y. Y. Kim, H. J. Kang, S. K. Ko and S. H. Chung, Sopungsungi-won(SP) Prevents the Onset of Hyperglycemia and Hyperlipidemia in Zucker Diabetic Fatty Rats. Arch Pharm Res., 25, 923 (2002)
  53. B. A. Shibib, L. A. Khan and R. Rahman, Hypoglycaemic Activity of Coccinia india and Morordica chlrantia in Diabetic Rats : Depression of the Hepatic Gluconeogenic Enzymes Glucose-6-phosphatase and Fructose-1,6-bisphosphatase and Elevation of Both Liver and Red Cell Shunt Enzyme Glucose-6-phosphate dehydrogenase. Biochem J., 15, 267 (1993)
  54. O. K. Kim, S. Y. Park, and K. H. Cho, Effect of Commelina commumis extract on blood glucose level and changes in enzymatic activity in alloxan diabetic rats. Kor. J. Pharmacogn, 22, 225 (1991)
  55. S. Y. Kim, H. I. Kim, T. H. Kim, S. S. Im and S. K. Park, SREBP-1c the Insulin Dependent Hepatic Glucokinase Expression. J. Bio. Chem, 279, 30823 (2004) https://doi.org/10.1074/jbc.M313223200

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