Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Anti-Inflammatory Effect of Haepyoejin-tang plus Antler water extract in Xylene-Application Mouse Ear Acute Inflammation Model

해표이진탕가녹용(解表二陳湯加鹿茸)이 Xylene으로 유발된 마우스의 급성 염증에 미치는 영향

  • Jung, Bong-Gyun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Jeon, Kwi-Ok (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Park, Mee-Yeon (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Choi, Hae-Yun (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Kim, Jong-Dae (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University) ;
  • Cho, Dong-Hee (Department of Internal Medicine, College of Oriental Medicine, Daegu Haany University)
  • 정봉균 (대구한의대학교 한의과대학 내과학교실) ;
  • 전귀옥 (대구한의대학교 한의과대학 내과학교실) ;
  • 박미연 (대구한의대학교 한의과대학 내과학교실) ;
  • 최해윤 (대구한의대학교 한의과대학 내과학교실) ;
  • 김종대 (대구한의대학교 한의과대학 내과학교실) ;
  • 조동희 (대구한의대학교 한의과대학 내과학교실)
  • Published : 2006.08.25
Download PDF
⟨ Previous Next ⟩

Abstract

In the present study, the anti-inflammatory effect of Haepyoeiin-tang plus Antler water extract water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on Dody weight and weights and histopathological observation of induced ear were conducted with ear histomorphometry, The increases of absolute and relative ear weight detected in vehicle control compared to that of sham, were significantly and dose-dependently inhibited by Haepyoejin-tang plus Antler in the present study, A classic acute inflammatory histological changes such as subcutaneous edema, hypertrophy and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Haepyoeiin-tang plus Antler. In addition, the increases of ear thickness half and thickness full detected in the vehicle control, were also dose-dependently decreased in the all Haepyoeiin-tang plus Antler-dosing groups. Base on these results, it is concluded that Haepyoeiin-tang plus Antler water extracts have a clear anti-inflammatory effect on the acute inflammation. However, somewhat lower anti-inflammatory effects were detected in Haepyoeiin-tang plus Antler water extracts compare to that of Dethamethason and Dicrofenac. About 500 mg/kg of Haepyoeiin-tang plus Antler water extracts have similar effect compared to that of Dicrofenac 15 mg/kg.

Keywords

References

  1. 대한병리학회 편. 병리학. 서울, 고문사, pp 65-68, 83, 1998
  2. 한용철. 임상호흡기학. 서울, 일조각, p 208, 219, 1993
  3. Barns, P., Pederson, S. Efficacy and safety of inhaled cortico- steroids in asthma, Am Rev Respir Dis, 148, 1-26, 1993 https://doi.org/10.1164/ajrccm/148.4_Pt_2.S1
  4. Waddell, A.N., Patel, S.K., Toma, A.G., Maw, A.R. Intranasal steroid sprays in the treatment of rhinitis: is one better than another? J Laryngol Otol, 117(11):843-845, 2003
  5. Roh, G.S., Seo, S.W., Yeo, S., Lee, J.M., Choi, J.W., Kim, E., Shin, Y., Cho, C., Bae, H., Jung, S.K., Kwack, K. Efficacy of a traditional Korean medicine, Chung-Sang-Bo-Ha-Tang, in a murine model of chronic asthma. Int Immunopharmacol, 5(2):427-436, 2005 https://doi.org/10.1016/j.intimp.2004.09.036
  6. Leclerc, N., Noh, T., Khokhar, A., Smith, E., Frenkel, B. Glucocorticoids inhibit osteocalcin transcription in osteoblasts by suppressing Egr2/Krox20-binding enhancer. Arthritis Rheum, 52(3):929-939, 2005 https://doi.org/10.1002/art.20872
  7. 賣得道. 中國醫學史略. 山西, 山西人民出版社, p 243, 1979
  8. 허준. 東醫寶鑑. 서울, 남산당, p 134, 481, 1987
  9. 신재용. 방약합편해설. 서울, 성보사, p 133, 1998
  10. 전국한의과대학 본초학교수 편저. 본초학. 서울, 영림사, p 123, 126, 460, 464, 478, 481, 484, 541, 1995
  11. 朴東一, 李珩九. 解表二陳湯이 鎭痛, 鎭痙, 解熱 및 O3 中毒으로 인한 흰쥐 肺損傷에 미치는 影響. 慶熙韓醫大論文集, 9, 463-470, 1986
  12. 이경태, 박동일. 해표이진탕이 흰쥐의 $SO_2$에 의한 호흡기손상에 미치는 영향. 한의학회지 17(2):178-190, 1996
  13. 백동진, 정희재, 이형구, 정승기. 해표이진탕가감방이 천식 모델 내의 Cytokine에 미치는 영향. 한의학회지 21(3):57-66, 2000
  14. Hosseinzadeh, H., Haddadkhodaparast, M.H., Arash, A.R. Antino-ciceptive, antiinflammatory and acute toxicity effects of Salvia leriifolia Benth seed extract in mice and rats. Phytother Res, 17(4):422-425, 2003 https://doi.org/10.1002/ptr.1154
  15. Kou, J., Ni, Y., Li, N., Wang, J., Liu, L., Jiang, Z.H. Analgesic and anti-inflammatory activities of total extract and individual fractions of Chinese medicinal ants Polyrhachis lamellidens Biol Pharm Bull, 28(1):176-180, 2005 https://doi.org/10.1248/bpb.28.176
  16. Ojewole, J.A. Antinociceptive, anti-inflammatory and anti-diabetic effects of Bryophyllum pinnatum (Crassulaceae) leaf aqueous extract. J Ethnopharmacol, 99(1):13-19, 2005 https://doi.org/10.1016/j.jep.2005.01.025
  17. Abdel-Salam, O.M., Baiuomy, A.R., El-batran, S., Arbid, M.S. Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat, Pharmacol Res, 49(2):133-142, 2004 https://doi.org/10.1016/j.phrs.2003.08.004
  18. Al-Majed, A.A., Khattab, M., Raza, M., Al-Shabanah, O.A., Mostafa, A.M. Potentiation of diclofenac-induced anti-inflammatory response by aminoguanidine in carrageenan- induced acute inflammation in rats: the role of nitric oxide. Inflamm Res, 52(9):378-382, 2003 https://doi.org/10.1007/s00011-003-1189-1
  19. Vetrichelvan, T., Jegadeesan, M. Effect of alcohol extract of Achyranthes aspera Linn. on acute and subacute inflammation. Phytother Res, 17(1):77-79, 2003 https://doi.org/10.1002/ptr.1070
  20. Giner-Larza, E.M., Manez, S., Giner, R.M., Recio, M.C., Prieto, J.M., Cerda-Nicolas, M., Rios, J.L. Anti-inflammatory triterpenes from Pistacia terebinthus galls. Planta Med, 68(4):311-315, 2002 https://doi.org/10.1055/s-2002-26749
  21. Hosseinzadeh, H., Ramezani, M., Fadishei, M., Mahmoudi, M. Anti-nociceptive, anti-inflammatory and acute toxicity effects of Zhumeria majdae extracts in mice and rats. Phytomedicine, 9(2):135-141, 2002 https://doi.org/10.1078/0944-7113-00097
  22. Gomez, M.A., Saenz, M.T., Garcia, M.D., Fernandez, M.A. Study of the topical anti-inflammatory activity of Achillea ageratum on chronic and acute inflammation models. Z Naturforsch [C], 54(11):937-941, 1999
  23. Rossetti, R.G., Seiler, C.M., Brathwaite, K., Zurier, R.B. Effect of Misoprostol on Acute and Chronic Inflammation. Am J Ther, 2(9):600-606, 1995 https://doi.org/10.1097/00045391-199509000-00004
  24. Hosseinzadeh, H., Younesi, H.M. Antinociceptive and anti-inflammatory effects of Crocus sativus L, stigma and petal extracts in mice. BMC Pharmacol, 2(1):7, 2002 https://doi.org/10.1186/1471-2210-2-7
  25. Zhong, Z., Zhou, G., Chen, X., Huang, P. Pharmacological study on the extracts from Typhonium flagelliforme Blume. Zhong Yao Cai, 24(10):735-738, 2001
  26. Hosseinzadeh, H., Ramezani, M., Salmani, G. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol, 73(3):379-385, 2000 https://doi.org/10.1016/S0378-8741(00)00238-5
  27. Atta, A.H., Alkofahi, A. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol, 60(2):117-124, 1998 https://doi.org/10.1016/S0378-8741(97)00137-2
  28. Kou, J., Ma, R., Zhu, D., Yan, Y. Blood-activating and anti-inflammatory actions of Polygala fallax. Zhong Yao Cai, 26(4):268-271, 2003
  29. Rotelli, A.E., Guardia, T., Juarez, A.O., de la Rocha, N.E., Pelzer, L.E. Comparative study of flavonoids in experimental models of inflammation. Pharmacol Res, 48(6):601-606, 2003 https://doi.org/10.1016/S1043-6618(03)00225-1
  30. De La Puerta, R., Martinez, E., Bravo, L., Ahumada, M.C. Effect of silymarin on different acute inflammation models and on leukocyte migration. J Pharm Pharmacol, 48(9):968-970, 1996 https://doi.org/10.1111/j.2042-7158.1996.tb06014.x