The Journal of Internal Korean Medicine (대한한방내과학회지)
- Volume 27 Issue 1
- /
- Pages.166-177
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- 2006
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- 1226-9174(pISSN)
Effect of Orostschys japonicus A. Berger on Apoptosis in K562 Cell Lines
와송(瓦松)이 만성 골수성 백혈병 세포주(K562)에서 세포사멸에 미치는 영향
- Yun, Kyoung-Su (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
- Kim, Young-Chul (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
-
Lee, Jang-Hoon
(Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
;
- Woo, Hong-Jung (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
- 윤경수 (경희대학교 한의과대학 간계내과학교실) ;
- 김영철 (경희대학교 한의과대학 간계내과학교실) ;
-
이장훈
(경희대학교 한의과대학 간계내과학교실)
;
- 우홍정 (경희대학교 한의과대학 간계내과학교실)
- Published : 2006.03.30
Abstract
Objectives : This study was performed to determine if Orostschys japonicus A. Berger has protective effects against CML in K562 cell lines. Materials and Methods : MTT assay, cell proliferation assay, Reverse transcription-polymerase reaction chain, RT-PCR, DNA fragmentation assay, Quantitative PCR were studied. Results : Orostschys japonicus A. Berger had no effects on Bax gene in K562 cell lines, but decreased Bcl-2 gene, and increased the Caspases-3 gene. This is indicate of induced apoptosis in K562 cell lines by Orostschys japonicus A. Berger. Conclusion : These results suggest that Orostschys japonicus A. Berger has effects on apatosis in K562 cell lines.