Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Protective Effects of the Methanol Extracts of Acanthopanax koreanum against Oxidative Stress

산화적 스트레스에 대한 섬오갈피 메탄올 추출물의 보호 효과

  • Lee, Sang-Eun (Institute of Food & Culture, R&D Center for Functional Food, Pulmuone Co. Ltd.) ;
  • Son, Dong-Wook (KT&G Central Research Institute) ;
  • Yoon, Year-Pill (Institute of Food & Culture, R&D Center for Functional Food, Pulmuone Co. Ltd.) ;
  • Lee, Sang-Yun (Institute of Food & Culture, R&D Center for Functional Food, Pulmuone Co. Ltd.) ;
  • Lee, Burm-Jong (Biohealth Products Research Center, Inje University) ;
  • Lee, Sang-Hyun (Department of Applied Plant Science, College of Industrial Science, Chung-Ang University)
  • 이상은 (풀무원 식문화연구원) ;
  • 손동욱 (KT&G 중앙연구원 인삼연구소) ;
  • 윤여필 (풀무원 식문화연구원) ;
  • 이상윤 (풀무원 식문화연구원) ;
  • 이범종 (인제대학교 바이오헬스소재연구센터) ;
  • 이상현 (중앙대학교 산업과학대학 식물응용과학과)
  • Published : 2006.03.30
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Abstract

The protective effects of the aqueous MeOH extracts of stem and root Acanthopanax koreanum Nakai against oxidative stress were investigated. Anti-oxidant activity of the stem extract of A. koreanum was observed in the DPPH free radical scavenging $(IC_{50}=58.7\;{\mu}g/ml)$ and the SOD test $(IC_{50}=17.52\;{\mu}g/ml)$. According to data analysis of cell survival ratio of normal fibroblasts, the skin irritation by both extracts from A. koreanum was concerned. However, in the skin primary parch test, both extracts obtained Grade I, which means that there was no skin irritation. After induction of oxidative irritation, cell survival ratio of normal fibroblasts was also monitored and it turned out that stress-inducing group with both extracts had more increased cell survival ratio. The cell extension of the stress-inducing group treated with the stem extract was most dominant in morphological study. Based on these results, the stem extract of A. koreanum showed the protective effect against oxidative stress on normal fibroblast.

Keywords

References

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