Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Mechanism for the Vascular Relaxation Induced by Butanol Extract of Agrimonia pilosa

선학초 부탄올 추출물의 혈관 이완 효과의 기전에 대한 연구

  • Hua, Cao-Li (Professional Graduate School of Oriental Medicine) ;
  • Lee, Jun-Kyung (Professional Graduate School of Oriental Medicine) ;
  • Cho, Kuk-Hyun (Professional Graduate School of Oriental Medicine) ;
  • Kwon, Tae-Oh (Medicinal Resources Research Institute (MeRRI),College of Life Science and Natural Resources, Wonkwang University) ;
  • Kwon, Ji-Woong (Medicinal Resources Research Institute (MeRRI),College of Life Science and Natural Resources, Wonkwang University) ;
  • Kim, Jin-Sook (Korea Institute of Oriental Medicine (KIOM)) ;
  • Sohn, Eun-Jin (Korea Institute of Oriental Medicine (KIOM)) ;
  • Lee, Ho-Sub (Professional Graduate School of Oriental Medicine,Medicinal Resources Research Institute (MeRRI)) ;
  • Kang, Dae-Gill (Professional Graduate School of Oriental Medicine, Medicinal Resources Research Institute (MeRRI))
  • 조려화 (한의학전문대학원 한약자원개발학과) ;
  • 이준경 (한의학전문대학원 한약자원개발학과) ;
  • 조국현 (한의학전문대학원 한약자원개발학과) ;
  • 권태오 (의약자원연구센터,원광대학교 생명자원과학대학) ;
  • 권지웅 (의약자원연구센터,원광대학교 생명자원과학대학) ;
  • 김진숙 (한국한의학연구원) ;
  • 손은진 (한국한의학연구원) ;
  • 이호섭 (한의학전문대학원 한약자원개발학과,의약자원연구센터) ;
  • 강대길 (한의학전문대학원 한약자원개발학과, 의약자원연구센터)
  • Published : 2006.06.30
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Abstract

The butanol extracts of Agrimonia pilosa (BAP) induced dose-dependent vascular relaxation of phenylephrine-precontracted aorta, which was abolished by removal of functional endothelium. Pretreatment of the endothelium-intact aortic tissues with $N^G$-nitro-L-arginine methyl ester (L-NAME) and 1H-[1,2,4]-oxadiazole-[$4,3-{\alpha}$]-quinoxalin-1-one(ODQ) inhibited the relaxation induced by BAP. BAP-induced vascular relaxation was also markedly attenuated by addition of verapamiI, while the relaxant effect of BAP was not blocked by indomethacine, glibenclamide, tetraethylammonium (TEA), atropine, or propranolo. In addition, incubation of endothelium-intact aortic rings with BAP increased the vascular production of cGMP. These results suggest that BAP relaxes vascular smooth muscle via endothelium-dependent nitric oxide/cGMP signaling pathway, which may be causally related with L-type $Ca^{2+}$ channels.

Keywords

References

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