Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
권호 표지

The Effects on Antimicrobial and Cytotoxicity of Hijikia Fusiformis Fraction

톳분획물의 항균 및 암세포 증식 억제효과

  • Shon, Jae-Hak (Department of Bio-food Material, Silla University) ;
  • Kang, Dae-Yeon (Marine Biotechnology Center for Biofunctional Material Industries) ;
  • Oh, Hyun-Cheol (Department of Bio-food Material Industries, Silla University) ;
  • Jung, Bok-Mi (Department of Food Science and Nutrition, Yosu National University) ;
  • Kim, Mi-Hyang (Department of Food and Nutrition, Silla University) ;
  • Shin, Mi-Ok (Department of Food and Nutrition, Silla University) ;
  • Bae, Song-Ja (Department of Food and Nutrition, Silla University,Marine Biotechnology Center for Biofunction Material Industries)
  • 손재학 (신라대학교 바이오식품소재학과) ;
  • 강대연 (마린-바이오 산업화지원센터) ;
  • 오현철 (신라대학교 바이오식품소재학과) ;
  • 정복미 (여수대학교 식품영양학과) ;
  • 김미향 (신라대학교 식품영양학과) ;
  • 신미옥 (신라대학교 식품영양학과) ;
  • 배송자 (신라대학교 식품영양학과,마린-바이오 산업화지원센터)
  • Published : 2006.07.31
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Abstract

In this study, we investigated antimicrobial and cytotoxicity effects to each· fraction extracted from Hizikiafusifonnis (HF), which were extracted methanol (HFM) and then the extract was fractionated into four different types: hexane (HFMH) , methanol (HFMM) , bulanol (HFMB) and aquous (HFMA) partition layers. We determined the cytotoxic effect of these layers on human cancer cells by MIT assay. Among various partition layers of HF, the HFMB and HFMM were showed the strong cytotoxic effects on cancer cell lines we used. The quinone reductase (QR) induced activity of the HFMB on HcpG2 cells at $150\;{\mu}g/mL$ concentration was 2.63 times more effective compared to the control value of 1.0. Although further studies are needed, the present work suggests that HF maybe a chemopreventive agent for the treatment of human cancer cells.

Keywords

References

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