Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Analgesic, cytotoxic and antioxidant activities of Trewia polycarpa bark

  • Published : 2006.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The crude ethanol extract of the stem bark of Trewia polycarpa (Family: Euphorbiaceae) was subjected to acetic acid induced writhing inhibition, Brine Shrimp lethality bioassay and 1, 1-diphenyl-2-picryl hydrazyl free radical scavenging assay for screening of analgesic, cytotoxic and antioxidant activity respectively. The extract produced significant (P < 0.001) writhing inhibition in acetic acid induced writhing in mice at the dose of 125, 250 and 500 mg/kg body weight respectively, which were comparable to the standard drug diclofenac sodium. The extract showed significant lethality to Brine Shrimp and the $LC_{50}$ value was $8\;{\mu}g/ml$. The extract showed prominent free radical scavenging activity ($IC_{50}$ about ${\sim}10\;{\mu}g/ml$) compare to standard drug ascorbic acid ($IC_{50}about\;{\sim}15\;{\mu}g/ml$). The results tend to suggest that the crude ethanol extract of the bark might possess analgesic, cytotoxic and antioxidant activities or active constituent(s) responsible for the activities.

Keywords

References

  1. Ahmed M, Shikha HA, Sadhu SK, Rahman MT, Datta BK (2001) Analgesic, Diuretic, and Antiinflammatory Principle from Scaparia dulcis. Pharmazie 56, 657-660.
  2. Derardt R, Jougney S, Delevalcee F, Falhout M. (1980) Release of prostaglandins E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 51, 17-24.
  3. Evans WC. (1989) Trease and Evan's Textbook of Pharmacognosy. 13th ed., Cambridge University Press, London.
  4. Gani A. (2003) Medicinal Plants of Bangladesh, Chemical Constituents and Uses, p. 412, Asiatic society of Bangladesh, Dhaka.
  5. Gupta M, Mazumdar UK, Sivahkumar T, Vamis MLM, Karki S, Sambathkumar R, Manikandan L. (2003) Antioxidant and anti-inflammatory activities of Acalypha fruticosa. Nig. J. Nat. Prod. Med. 7, 25-29.
  6. IJC (Indian Journal of Chemistry). (1964) p. 2, 129, 171.
  7. Lorke D. (1983) Anew approach to acute toxicity testing. Arch. Toxicol. 54, 275-287. https://doi.org/10.1007/BF01234480
  8. Meyer. (1982) Phytochemical methods (a guide to modern techniques to plant analysis). 3rd ed p. 335-337, Champan and Hall.
  9. McLaughlin JL, Anderson JE, Chang CJ. (1988) Bioactive components of Allamanda schottii. J. Nat. Prod. 51, 307-308. https://doi.org/10.1021/np50056a018
  10. Sadhu SK, Okuyama E, Fujimoto H, Ishibashi M. (2003) Separation of Leucas aspera,a medicinal Plant of Bangladesh, Guided by Prostaglandin Inhibitory and Antioxidant Activities. Chem. Pharm. Bull. 51, 595-598. https://doi.org/10.1248/cpb.51.595
  11. Taesotikul T, Panthong A, Kanjanapothi D, Verpoorte R, SCheffer JJC. (2003) Antiinflammatory, antipyretic and antinociceptive activities of Tabernaemontana pandacaqui Poir. J. Ethnopharmacol. 84, 31-35. https://doi.org/10.1016/S0378-8741(02)00264-7
  12. Whittle BA. (1964) The use of changes in capillary permeability in mice to distinguish between narcotic and non-narcotic analgesics. Br. J. Pharmacol. Chemother. 22, 246.
  13. Yusuf M, Chowdhury JU, Wahab MA, Begum J. (1994) Medicinal Plants of Bangladesh p. 17-266, BCSIR, Dhaka, Bangladesh.

Cited by

  1. Pharmacological Evaluation of Bangladeshi Medicinal Plants for Antioxidant Activity vol.46, pp.10-11, 2008, https://doi.org/10.1080/13880200802215735