The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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The Effect of Bangpungtongsung-San on Model of Allergic Rhinitis

알러지성 비염 병태 모델에 대한 방풍통성산(防風通聖散)의 항알러지 효과

  • 김희정 (경희대학교 한의과대학 안이비인후피부과학교실) ;
  • 박외숙 (경희대학교 한의과대학 안이비인후피부과학교실) ;
  • 김규석 (경희대학교 한의과대학 안이비인후피부과학교실) ;
  • 차재훈 (경희대학교 한의과대학 안이비인후피부과학교실) ;
  • 김윤범 (경희대학교 한의과대학 안이비인후피부과학교실)
  • Published : 2006.04.25
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Abstract

Background and Objective : Allergic rhinitis is a IgE-mediated hypersensitive reaction at nasal mucosa. In oriental medicine, Bangpungtongsung-San is clinically widely used for the treatment of the allergic rhinitis. The objective of this study is to investigate the effects of Bangpungtongsung-San on allergic rhinitis experimentally. Material and Methods : BALB/c mouse were divided into there groups: intact, control, experimental groups. Control and experimental group were induced allergic rhinitis by Ovalbumin as· the method of Levin and Vaz. Experimental group was orally administered the Bangpungtongsung-San for 28days. Total IgE, Interleukin-4, Interleukin-5 and $Interferon-{\gamma}$ were measured at three groups. The statistical significance was examined by Independent Samples T test. Results : 1. The experimental group shows increase of $IFN-{\gamma}$ by 17% compared with control group but there was no statistical significance. 2. The experimental group shows increase of IL-4 and IL-5 compared with control group but there was no statistical significance. 3. The experimental group shows increase of Total IgE and diminution of OVA-specific IgE by 32% compared with control group but there was no statistical significance. Conclusion : The effect of Bangpungtongsung-San on allergic rhinitis is not immunological but seems to be anti-imflammatory and anti-stress effect.

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