The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Effects of Samkieum on LDL Oxidation in Macrophage Cell

지단백산화(脂蛋白酸化)에 따른 대식세포(大食細胞) 활성(活性)에 미치는 삼기음(三氣飮)의 영향(影響)

  • 이희조 (경원대학교 한의과대학 안이비인후피부과학교실) ;
  • 황귀서 (경원대학교 한의과대학 예방의학교실) ;
  • 김경준 (경원대학교 한의과대학 안이비인후피부과학교실)
  • Published : 2006.08.25
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Abstract

The oxidative notification of low density lipoprotein(LDL) has been implicated in the development of atherosclerosis. Oxidized LDL are found in macrophage foam cell, and it can induce an macrophage proliferation in atherosclerotic plaque. In this study, we investigated the hypothesis that Samkieum may reduce atherosclerosis by lowering the oxidiazability of LDL, To achieve this goal, we examined the effect of Samkieum on LDL oxidation nitric oxide production in mouse macrophage cell line, RAW264.7, and the effect of Samkieum on cupuric sulfate-induced cytotoxicity, LDH release, and macrophage activity. Samkieum inhibited the generation of oxidized LDL from native LDL in RAW264.7 cell culture, and decreased the release of LDH from cupric sulfate-stimulated RAW264.7 cell. In other experiments, Samkieum activated RAW264.7 cell, and prolonged the survival time, and increased nitric oxide production in Raw 264.7 cells.

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