Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Standardization of Morinda officinalis How

파극천의 품질 표준화 연구

  • Lee, Hye-Won (Department of Quality Control of Herbal Medicine, Korea Institute of Oriental Medicine) ;
  • Park, So-Young (Department of Quality Control of Herbal Medicine, Korea Institute of Oriental Medicine) ;
  • Choo, Byung-Kil (Department of Quality Control of Herbal Medicine, Korea Institute of Oriental Medicine) ;
  • Chun, Jin-Mi (Department of Quality Control of Herbal Medicine, Korea Institute of Oriental Medicine) ;
  • Lee, A-Yeong (Department of Quality Control of Herbal Medicine, Korea Institute of Oriental Medicine) ;
  • Kim, Ho-Kyoung (Department of Quality Control of Herbal Medicine, Korea Institute of Oriental Medicine)
  • 이혜원 (한국한의학연구원 검사사업부) ;
  • 박소영 (한국한의학연구원 검사사업부) ;
  • 추병길 (한국한의학연구원 검사사업부) ;
  • 천진미 (한국한의학연구원 검사사업부) ;
  • 이아영 (한국한의학연구원 검사사업부) ;
  • 김호경 (한국한의학연구원 검사사업부)
  • Published : 2006.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

Morinda officinalis How. (Rubiaceae) has been used as tonic, warming, sex impulse and anti-inflammatory agents. Two known anthraquinones, rubiadin-1-methyl ether (I) and rubiadin (II) were isolated from root of M. officinalis. Their structures were identified using NMR and literature comparisons. The contents of I in eighteen M. officinalis were evaluated by HPLC-PDA. Chromatography was performed using a reversed-phase system with Luna $C_{18}$ (2) column and acetonitrile-water (50:50, v/v) with a flow rate of 1.0 mL/min under UV 280 nm. Under these conditions, the content of rubiadin-1-methyl ether was 0.013%.

Keywords

References

  1. 김호철 (2004) 한약약리학, 443-445. 집문당, 서울
  2. 지형준, 이상인 편저 (1989) 대한약전외한약(생약)규격집 주해서,494. 한국메디칼인덱스사, 서울
  3. 전국한의과대학본초학교수 공편저 (2000) 본초학, 549-550. 영림사,서울
  4. 김창민, 신민교, 안덕균, 이경순 외 (1998) 중약대사전, vol. 10, 5766-5770. 도서출판 정담, 서울
  5. Masayuki, Y, Shoko Y., Hiroko N., Johji Y. and Nobutoshi M. (1995) Chemical constituents of Chinese natural medicine, Morindae Radix, the dried roots of Morinda officinalis How.; Structures of Morindolide and Moroffcinaloside. Chem. Pharm. Bull., 43(9): 1462-1465 https://doi.org/10.1248/cpb.43.1462
  6. Joshi, K. C., Singh, P. and Pardasani, R. T. (1977) Chemical components of the roots of Tectona grandis and Gmelina arborea. Planta Medica, 32(1): 71-75 https://doi.org/10.1055/s-0028-1097561
  7. Kuiper, J. and Labadie, R. P. (1981) Polyploid complexes within the genus galium part; Anthraquinones of Galiun album. Planta Medica, 42(4): 390-399 https://doi.org/10.1055/s-2007-971661
  8. Chang, P. and Lee, K. H. (1984) Cytotoxic antileukemic anthraquinones from Morinda parvifolia. Phytochemistry, 23(8): 1733-1736 https://doi.org/10.1016/S0031-9422(00)83480-9
  9. Imre, S., Tulus, R. and Sengn, I. (1971) Zwei neue anthrachinon-verbindungen aus digitalis ferruginea. Tetrahedron Lett., 12(48): 4681-4683 https://doi.org/10.1016/S0040-4039(01)97561-6
  10. Greca, M. P., Monaco, P. and Previtera, L. (1990) Stigmasterols from typha latifolia. J. Nat. Prod., 53(6): 1430-1435 https://doi.org/10.1021/np50072a005
  11. Nukatani, M., Miyazaki, Y, Iwashita, T., Naoki, H. and Hase, T. (1989) Triterpenes from Ilex rotunda fruits. Phytochemistry, 28(5): 1479-1482 https://doi.org/10.1016/S0031-9422(00)97768-9
  12. Numata, A., Hokimoto, K., Takemura, T., Katsuno, T. and Yamamoto, K. (1984) Plant constituents biologically active to insects. V. Antifeedants for the Larvae of the Yellow Butterfly, Eurema hecabe mandarina, in Osmunda japonica. (1). Chem. Pharm. Bull., 32(7): 2815-2820 https://doi.org/10.1248/cpb.32.2815
  13. Kotama, J., Moritaa, I., Tagaharaa, K., Mukainakab, O. T., Tokudab, H. and Nishinob, H. (2001) Inhibitory effects of anthraquinones and bianthraquinones, Epstein-Barr virus activation, Cancer Lett., 170(1): 15-18 https://doi.org/10.1016/S0304-3835(01)00566-3
  14. Taloua, J. R., Verbernea, M. C, Muljonoa, R. A. B., Tegelenc, L. J. P., Bernala, B. G, Linthorstb, H. J. M., Wullemsc, G J., Bolb, J. F. and Verpoortea, R. (2001) Isochorismate synthase transgenic expression in Catharanthus roseus cell suspensions, Plant Physiol. Biochem., 39: 595-602 https://doi.org/10.1016/S0981-9428(01)01279-7
  15. Loy, G, Cottiglia, F., Garau, D., Deidda, D., Pompei, R. and Bonsignore, L. (2001) Chemical composition and cytotoxic and antimicrobial activity of Calycotome villosa (Poiret) Link leaves, II Farmaco, 56(5-7): 433-436 https://doi.org/10.1016/S0014-827X(01)01056-4
  16. Babu, K. S., Srinivas, P. V., Praveen, B., Kishore, K. H., Murty, U. S. and Rao, J. M. (2003) Antimicrobial constituents from the rhizomes of Rheum emodi, Phytochemistry, 62(2): 203-207 https://doi.org/10.1016/S0031-9422(02)00571-X
  17. Sadeghi-Aliabadi, H., Tabarzadi, M. and Zarghi, A. (2004) Synthesis and cytotoxic evaluation of two novel anthraqui-none derivatives. II Farmaco, 59(8): 645-649 https://doi.org/10.1016/j.farmac.2004.03.006
  18. Hiramatsu, T., Imoto, M., Koyano, T. and Umezawa, K. (1993) Induction of normal phenotypes if ras-transformed cells by damnacanthal from Morinda citrifolia. Cancer Lett., 73(3): 161-166 https://doi.org/10.1016/0304-3835(93)90259-C
  19. Brisson, C. and Brassard, P. (1981) Regiospecific reactions of some vinylogous ketone acetals wiyh haloquinones and their regioselective formation by dienolization. J. Org. Chem., 46(9): 1810-1814 https://doi.org/10.1021/jo00322a012
  20. Rath, G, Ndonzao, M. and Hostettmann, K. (1995) Antifungal anthraquinones from Morinda lucida. J. Nat. Prod., 59(2): 107-114